This year's Nobel Prize in Physiology and Medicine was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi for their discoveries concerning peripheral immune tolerance and regulatory T cells. These immune cells play an important role in protecting us from autoimmune diseases, and key to their development and function is the transcription factor FOXP3...Read more

This month, specific expression of Transmembrane protein 52B (gene: TMEM52B) in distal tubules in the kidney is highlighted with multiplex immunohistochemistry (mIHC/IF)...Read more

The ability to degrade intracellular proteins in a controlled manner is an important cellular function. It is utilized to remove and recycle unnecessary, damaged and/or harmful components, which is an essential ability to maintain cellular homeostasis and health. The most well-known routes to selective degradation of proteins are proteasomal degradation and selective autophagy. In both pathways, proteins targeted for degradation are marked polyubiquitination (polyUb), with chains that are linked at lysine K48 and K63, respectively...Read more

Sperm head structural protein cylicin 1 (gene: CYLC1) is visualized in late stage spermatogenesis with multiplex immunohistochemistry (mIHC/IF)...Read more

Primary cilia are thin projections that are present on most cell types and that serve critical functions during multiple biological processes, including embryonic development. They are present in a single copy per cell and act much like an antenna, receiving and sending signals to the environment. This makes them crucial for coordinating cellular processes early in life...Read more