In the endoplasmic reticulum (ER), ATP is essential for the folding, maturation, transport and degradation of proteins. As there is no pathway for endogenous ATP synthesis in the ER, these constant processes all rely on ATP import from the cytosol, but it is not until recently that the responsible transporter has been identified...Read more

Insulin like growth factor 2 mRNA binding protein 1 (gene: IGF2BP1) is localized to undifferentiated sperm cells in testis...Read more

In 2021, Trey Idekers team at UCLA in collaboration with Emma Lundbergs team at KTH and Stanford presented a new way of creating hierarchical maps of subcellular protein organization by integrating data from immunofluorescence images from the HPA with protein interaction data. The resulting cell map was referred to as the multi-scale integrated cell (MuSIC 1.0). Four years later, the same team has now released the next version of such a multimodal cell map, again accompanied by a prestigious publication in Nature...Read more

Calcium release activated channel regulator 2A (gene: CRACR2A) displays a diverse expression pattern in the salivary gland...Read more

Since the release of HPA v24, we are providing a unique highly-multiplexed data set showing the distribution of a large set of reference markers across all major tissues and organs in the human body. The images have been generated using CODEX technology for simultaneous immunostaining of 47 marker proteins across the panel of normal HPA tissue microarrays. The markers have been selected to help distinguish different tissue structures and cell types, and thus histological features, in the TMAs...Read more