The Metabolic Atlas

The Metabolic Atlas portion of the Tissue Atlas enables exploration of protein function and tissue-specific gene expression in the context of the human metabolic network. For proteins involved in metabolism, a metabolic summary is provided that describes the metabolic subsystems/pathways, cellular compartments, and number of reactions associated with the protein. Over 120 manually curated metabolic pathway maps facilitate the visualization of each protein's participation in different metabolic processes. Each pathway map is accompanied by a heatmap detailing the mRNA levels across 37 different tissue types for all proteins involved in the metabolic pathway.


METABOLIC MAPS

Maps are organized by individual pathways to facilitate visualization of metabolic areas of interest. Further detail and full cellular compartment maps are available at metabolicatlas.org.

Metabolic subsystem

Histidine metabolism

HAL
Pentose phosphate pathway

RBKS

Cellular compartment



Table 1. A complete list of the pathways details in the Metabolic Atlas and number of enzymes involved in each pathway.


Pathway # genes
Acyl-CoA hydrolysis 8
Acylglycerides metabolism 38
Alanine; aspartate and glutamate metabolism 40
Amino sugar and nucleotide sugar metabolism 32
Aminoacyl-tRNA biosynthesis 21
Androgen metabolism 23
Arachidonic acid metabolism 106
Arginine and proline metabolism 63
Ascorbate and aldarate metabolism 10
Beta oxidation of branched-chain fatty acids (mitochondrial) 10
Beta oxidation of di-unsaturated fatty acids (n-6) (mitochondrial) 16
Beta oxidation of di-unsaturated fatty acids (n-6) (peroxisomal) 11
Beta oxidation of even-chain fatty acids (mitochondrial) 13
Beta oxidation of even-chain fatty acids (peroxisomal) 9
Beta oxidation of odd-chain fatty acids (mitochondrial) 12
Beta oxidation of phytanic acid (peroxisomal) 24
Beta oxidation of poly-unsaturated fatty acids (mitochondrial) 11
Beta oxidation of unsaturated fatty acids (n-7) (mitochondrial) 14
Beta oxidation of unsaturated fatty acids (n-7) (peroxisomal) 9
Beta oxidation of unsaturated fatty acids (n-9) (mitochondrial) 14
Beta oxidation of unsaturated fatty acids (n-9) (peroxisomal) 9
Beta-alanine metabolism 21
Bile acid biosynthesis 99
Bile acid recycling 16
Biopterin metabolism 12
Biotin metabolism 4
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METABOLICATLAS.ORG

The metabolic features of the Tissue Atlas are provided by metabolicatlas.org, which provides further detailed biochemical information on over 10,000 reactions, 4,000 metabolites, and 3,000 enzymes involved in human metabolism. Interactive 2D and 3D maps of the metabolic network are provided, and are organized by cellular compartment or metabolic subsystem to facilitate visualization of metabolic areas of interest. A global search functionality allows for advanced filtering, and the same data is available through the API.