The Human Protein Atlas (HPA) consortium is committed to aid in the fight against the health consequences of the Covid-19 pandemic.
The program involves both efforts to increase the knowledge about the human host proteins that interact with SARS-CoV-2, and efforts to develop diagnostic tools and therapeutic drugs to combat the pandemic. Read more in the news article and press release.
A major effort has also been put into detailed mapping of the presence in the entire human body of the enzyme ACE2, the suggested key protein involved in SARS-CoV-2 host cell entry.
SARS-CoV-2 related proteins
Below is a summary of the tissue and cell expression patterns of known SARS-CoV-2 interacting human proteins, based on transcriptomics and antibody-based proteomics. If you have a suggestion for other human proteins to include here, please send an email to email@example.com
SARS-CoV-2 entry receptors: ACE2
For more information about ACE2 and its cell type-specific expression in human tissues, also see: Hikmet et al "The protein expression profile of ACE2 in human tissues".
SARS-CoV-2 entry associated proteases: TMPRSS2, CTSB, CTSL
SARS-CoV-2 interacting proteins
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Human proteins interacting with SARS-CoV-2 according to Gordon et al "A SARS-CoV-2 protein interaction map reveals targets for drug repurposing".