In the endoplasmic reticulum (ER), ATP is essential for the folding, maturation, transport and degradation of proteins. As there is no pathway for endogenous ATP synthesis in the ER, these constant processes all rely on ATP import from the cytosol, but it is not until recently that the responsible transporter has been identified...Read more

Insulin like growth factor 2 mRNA binding protein 1 (gene: IGF2BP1) is localized to undifferentiated sperm cells in testis...Read more

In a correspondence in Nature Medicine an initiative with the aim to connect research with healthcare and establish Sweden as a major player in the field of data-driven precision medicine was presented...Read more

In 2021, Trey Idekers team at UCLA in collaboration with Emma Lundbergs team at KTH and Stanford presented a new way of creating hierarchical maps of subcellular protein organization by integrating data from immunofluorescence images from the HPA with protein interaction data. The resulting cell map was referred to as the multi-scale integrated cell (MuSIC 1.0). Four years later, the same team has now released the next version of such a multimodal cell map, again accompanied by a prestigious publication in Nature...Read more

Among the about 20,000 genes giving rise to the human proteome there are still many rather unknown but potentially interesting genes that deserve some extra attention. Here we will focus on C19orf67, a gene with low evidence but specific and consistent expression detected in the testis across different datasets...Read more