Tripartite motif-containing protein 73 (gene: TRIM73) is a protein whose expression at the protein level was unveiled only recently by a team affiliated with the Human Protein Atlas. Multiplex immunohistochemistry allowed them to confirm its cell-type specific localization in the ovary, thus significantly advancing our understanding of both TRIM73 and the ovary proteome...Read more

How can sperm swim? The outer dense fiber of sperm tails 4 (gene: ODF4) is one of the proteins thought to be important for sperm tail movement that propels the sperm forward. Multiplex immunohistochemistry technique enabled us to examine the expression of this protein during sperm development (spermatogenesis) in more detail than ever before...Read more

Platelet factor 4 (gene: PF4) is a chemokine expressed by platelets (thrombocytes) - blood cell fragments that play a key role during blood clotting. Although its normal physiological role is not completely understood, PF4 is implicated in antimicrobial activity and life-threatening thrombosis caused by adenovirus vector covid-19 vaccines...Read more

This month we turn the spotlight to retinol binding protein 2 (gene: RBP2), which plays an important role in the uptake of vitamin A in the intestines. Now that winter has arrived, we increasingly need good night vision and a strong immune system - two physiological processes that we have vitamin A to thank for...Read more

In this image of the month, we focus on the transcription factor SNAI1, one of the major drivers of EMT. EMT is the cellular process during which epithelial cells loosen their connections with neighboring cells and modify their interactions with the extracellular matrix, thus acquiring mesenchymal traits and a more motile phenotype. EMT is crucial for the formation of tissues and organs during embryogenesis, however in the disease context, the same process is also associated with fibrosis, cancer progression and metastasis (Nieto et al, 2016 )...Read more