Protein classes

The protein classes show a summary of genes identified in various protein classifications. Each row shows the total number of genes for a particular protein class as well as the as well the number of those genes with experimental data in HPA for the corresponding proteins based on antibody-based profiling. All protein classes have been categorized into three different tables: "Function and compartment based", "Disease and drug related", and "Evidence based". Clicking one of the numbers in the tables retrieves a search result with the selection of genes belonging to the class, along with additional data. For each class, where applicable, there is also a link to the original source of the gene list. A number of classes contain a selection of subclasses which unfolds when the parent class (shown in bold and with arrows) is clicked. Some subclasses (marked with an asterisk) are not included in the total number of genes for the parent class.

Protein class No of genes No of genes
with antibodies

Function and compartment basedi

Enzymes 3520 3295
CD markers 373 332 UniProt
Blood group antigen proteins 31 27 UniProt
Nuclear receptors 49 47 NucleaRDB
Transporters 1471 1308 TCDB
Ribosomal proteins 177 174 UniProt
G-protein coupled receptors 775 391 UniProt
Voltage-gated ion channels 133 105 IUPHAR-DB
Predicted membrane proteins 5520 4503 MDM
Predicted secreted proteins 1708 1358 HPA
Predicted intracellular proteins 15579 14122 HPA
Plasma proteins 3741 3545 Plasma Proteome Database
Transcription factors 1496 1370 UMG
RNA polymerase related proteins 30 30 KEGG
RAS pathway related proteins 232 209 KEGG
Citric acid cycle related proteins 30 29 KEGG

Disease and drug relatedi

Cancer-related genes 1675 1585
Candidate cardiovascular disease genes 155 144 Plasma Proteome Institute
Disease related genes 4009 3713 UniProt
FDA approved drug targets 754 666 Drugbank
Potential drug targets 1326 1233 HPA

Evidence basedi

Mapped to UniProt SWISS-PROT 18977 16800 UniProt
Mapped to neXtProt 18940 16793 neXtProt
Protein evidence (Peptideatlas) 16017 14918 Peptideatlas