Protein classes

The protein classes show a summary of genes identified in various protein classifications. Each row shows the total number of genes for a particular protein class as well as the as well the number of those genes with experimental data in HPA for the corresponding proteins based on antibody-based profiling. All protein classes have been categorized into three different tables: "Function and compartment based", "Disease and drug related", and "Evidence based". Clicking one of the numbers in the tables retrieves a search result with the selection of genes belonging to the class, along with additional data. For each class, where applicable, there is also a link to the original source of the gene list. A number of classes contain a selection of subclasses which unfolds when the parent class (shown in bold and with arrows) is clicked. Some subclasses (marked with an asterisk) are not included in the total number of genes for the parent class.

Protein class	No of genes	No of genes with antibodies	Source
Function and compartment basedⁱ The "Function and compartment based" table contains functional classes of proteins such as transcription factors and enzymes, as well as proteins located to specific compartments of the cell, such as the predicted membrane proteins. The "Predicted membrane proteins" subclasses have been previously described in more detail in a publication. The class "Secreted proteins predicted by MDSEC" includes proteins not containing transmembrane regions and having a signal peptide predicted by at least two of the three signal peptide prediction methods SignalP4.0, Phobius, and SPOCTOPUS.
Enzymes	3520	3295
ENZYME proteins	3275	3083	ENZYME
Oxidoreductases	406	376	ENZYME
Transferases	1519	1434	ENZYME
Hydrolases	1061	991	ENZYME
Lyases	137	131	ENZYME
Isomerase	103	102	ENZYME
Ligase	105	104	ENZYME
Peptidases	492	440	UniProt/Merops
Aspartic-type peptidases	17	16	UniProt/Merops
Cysteine-type peptidases	159	153	UniProt/Merops
Metallopeptidases	129	113	UniProt/Merops
Serine-type peptidases	163	135	UniProt/Merops
Threonine-type peptidases	20	19	UniProt/Merops
Kinases	501	480	UniProt
AGC Ser/Thr protein kinases	56	56	UniProt
Tyr protein kinases	88	85	UniProt
TKL Ser/Thr protein kinases	34	30	UniProt
STE Ser/Thr protein kinases	55	55	UniProt
RGC receptor guanylate cyclase kinases	5	2	UniProt
NEK Ser/Thr protein kinases	11	11	UniProt
CMGC Ser/Thr protein kinases	61	58	UniProt
CK1 Ser/Thr protein kinases	12	12	UniProt
CAMK Ser/Thr protein kinases	73	70	UniProt
Atypical kinases	27	26	UniProt
CD markers	373	332	UniProt
Blood group antigen proteins	31	27	UniProt
Nuclear receptors	49	47	NucleaRDB
Transporters	1471	1308	TCDB
Transporter channels and pores	470	407	TCDB
Electrochemical Potential-driven transporters	405	365	TCDB
Primary Active Transporters	153	143	TCDB
Transport Electron Carriers	12	9	TCDB
Accessory Factors Involved in Transport	202	185	TCDB
Ribosomal proteins	177	174	UniProt
G-protein coupled receptors	775	391	UniProt
Family 3 (C) receptors	21	17	UniProt
GPCRs excl olfactory receptors	393	291	UniProt
Adenosine and adenine nucleotide receptors	17	16	UniProt
Chemokines and chemotactic factors receptors	29	24	UniProt
Lysolipids receptors	14	11	UniProt
Odorant/olfactory and gustatory receptors	382	100	UniProt
Opsins	9	5	UniProt
Serotonin receptors	12	10	UniProt
Family 2 (B) receptors	47	40	UniProt
Family T2R receptors (taste receptor GPCRs)	24	7	UniProt
Family fz/smo receptors	11	10	UniProt
Voltage-gated ion channels	133	105	IUPHAR-DB
Calcium-Activated Potassium Channels	7	7	IUPHAR-DB
CatSper and Two-Pore Channels	4	3	IUPHAR-DB
Cyclic Nucleotide-Regulated Channels	9	7	IUPHAR-DB
Inwardly Rectifying Potassium Channels	15	13	IUPHAR-DB
Transient Receptor Potential Channels	24	16	IUPHAR-DB
Two-P Potassium Channels	14	9	IUPHAR-DB
Voltage-Gated Calcium Channels	10	9	IUPHAR-DB
Voltage-Gated Potassium Channels	41	33	IUPHAR-DB
Voltage-Gated Sodium Channels	9	8	IUPHAR-DB
Predicted membrane proteins	5520	4503	MDM
Prediction method-based	5520	4503	MDM
Membrane proteins predicted by MDM	5520	4503	MDM
MEMSAT3 predicted membrane proteins *	7308	6013	MEMSAT3
MEMSAT-SVM predicted membrane proteins *	6354	5213	MEMSAT-SVM
Phobius predicted membrane proteins *	5812	4751	Phobius
SCAMPI predicted membrane proteins *	6422	5345	SCAMPI
SPOCTOPUS predicted membrane proteins *	7738	6531	SPOCTOPUS
THUMBUP predicted membrane proteins *	7199	5993	THUMBUP
TMHMM predicted membrane proteins *	5576	4482	TMHMM
GPCRHMM predicted membrane proteins *	838	442	GPCRHMM
# TM segments-based	5520	4503	MDM
1TM proteins predicted by MDM	3159	2763	MDM
9TM proteins predicted by MDM	135	119	MDM
8TM proteins predicted by MDM	167	145	MDM
7TM proteins predicted by MDM	967	561	MDM
6TM proteins predicted by MDM	316	273	MDM
5TM proteins predicted by MDM	291	241	MDM
4TM proteins predicted by MDM	551	469	MDM
3TM proteins predicted by MDM	583	507	MDM
2TM proteins predicted by MDM	954	845	MDM
>9TM proteins predicted by MDM	495	448	MDM
Predicted secreted proteins	1708	1358	HPA
Secreted proteins predicted by MDSEC	2943	2492	HPA
SignalP predicted secreted proteins *	2525	2111	SignalP
Phobius predicted secreted proteins *	3338	2854	Phobius
SPOCTOPUS predicted secreted proteins *	3710	3178	SPOCTOPUS
Predicted intracellular proteins	15579	14122	HPA
Intracellular proteins predicted by MDM and MDSEC	14928	13554	HPA
Plasma proteins	3741	3545	Plasma Proteome Database
Transcription factors	1496	1370	UMG
Yet undefined DNA-binding domains	19	18	UMG
Basic domains	173	159	UMG
Zinc-coordinating DNA-binding domains	778	720	UMG
Helix-turn-helix domains	392	348	UMG
Other all-alpha-helical DNA-binding domains	46	42	UMG
alpha-Helices exposed by beta-structures	13	12	UMG
Immunoglobulin fold	62	59	UMG
beta-Hairpin exposed by an alpha/beta-scaffold	14	13	UMG
beta-Sheet binding to DNA	5	5	UMG
beta-Barrel DNA-binding domains	3	3	UMG
RNA polymerase related proteins	30	30	KEGG
RAS pathway related proteins	232	209	KEGG
Citric acid cycle related proteins	30	29	KEGG
Disease and drug relatedⁱ The "Disease and drug related" table consists of a selection of gene lists related to diseases such as cancer and cardiovascular disease as well as genes associated with drug targets according to Drugbank.
Cancer-related genes	1675	1585
Candidate cancer biomarkers	1036	962	Plasma Proteome Institute
Mutated cancer genes	256	253	Publication
Mutational cancer driver genes	285	282	Publication
COSMIC somatic mutations in cancer genes	569	555	COSMIC
COSMIC Amplifications	24	23	COSMIC
COSMIC Splicing Mutations	73	72	COSMIC
COSMIC Somatic Mutations	529	517	COSMIC
COSMIC Other Mutations	37	37	COSMIC
COSMIC Nonsense Mutations	153	150	COSMIC
COSMIC Missense Mutations	252	246	COSMIC
COSMIC Large Deletions	40	40	COSMIC
COSMIC Germline Mutations	102	97	COSMIC
COSMIC Frameshift Mutations	156	151	COSMIC
COSMIC Translocations	309	300	COSMIC
Candidate cardiovascular disease genes	155	144	Plasma Proteome Institute
Disease related genes	4009	3713	UniProt
FDA approved drug targets	754	666	Drugbank
Biotech drugs	143	123	Drugbank
Small molecule drugs	645	569	Drugbank
Potential drug targets	1326	1233	HPA
Evidence basedⁱ For the "Evidence based" classes, further information can be found in the more detailed description of the protein evidence as well as on the protein evidence page.
Mapped to UniProt SWISS-PROT	18977	16800	UniProt
UniProt - Evidence at protein level	15070	13946	UniProt
UniProt - Evidence at transcript level	3232	2523	UniProt
UniProt - Inferred from homology	538	255	UniProt
UniProt - Predicted	101	62	UniProt
UniProt - Uncertain	58	32	UniProt
Mapped to neXtProt	18940	16793	neXtProt
neXtProt - Evidence at protein level	17227	15802	neXtProt
neXtProt - Evidence at transcript level	1326	822	neXtProt
neXtProt - Inferred from homology	316	133	neXtProt
neXtProt - Predicted	30	17	neXtProt
neXtProt - Uncertain	56	32	neXtProt
Protein evidence (Peptideatlas)	16017	14918	Peptideatlas

Protein classes

Disease and drug relatediThe "Disease and drug related" table consists of a selection of gene lists related to diseases such as cancer and cardiovascular disease as well as genes associated with drug targets according to Drugbank.

Evidence basediFor the "Evidence based" classes, further information can be found in the more detailed description of the protein evidence as well as on the protein evidence page.

Disease and drug relatedⁱ
The "Disease and drug related" table consists of a selection of gene lists related to diseases such as cancer and cardiovascular disease as well as genes associated with drug targets according to Drugbank.

Evidence basedⁱ
For the "Evidence based" classes, further information can be found in the more detailed description of the protein evidence as well as on the protein evidence page.