In a recent study published in Nature it was discovered that the polyamine spermine acts as a chelator of intracellular iron and thus as a suppressor of ferroptosis. Spermine is a polyamine metabolite that is essential for cellular homeostasis, with known roles ranging from DNA stabilization and RNA processing to protein synthesis and ion channel regulation. Dysregulation of spermine metabolism is implicated in various malignant, neurodegenerative and inflammatory diseases...Read more

In the Episode 82 of of the Proteomics show podcast series "Alt Proteomics" HPA researcher Dr Cecilia Lindskog talks about the importance of proteomics data integration together with the hosts Benjamin Neely and Ben Orsburn...Read more

In the new release version 25.1 of the Human Protein Atlas, a major dataset based on Deep Visual Proteomics has been integrated in the Single cell Resource to provide mass-spectrometry based proteomics at an unprecedented resolution for a large number of cell types and tissues...Read more

The differences in blood protein levels during childhood and early adulthood were recently explored in an article published in Nature Communications...Read more

The Human Protein Atlas supports the global effort announced by Biohub to create an open data foundation for AI-accelerated biology. The initiative brings together leading institutions and international consortia to generate the technologies and multi-modal datasets needed to build predictive models of the human cell...Read more