The defense mechanism of our adaptive immune system relies on the antigen-recognition abilities of two molecules: T cell receptors (TCRs), attached to the surface of T cells, and immunoglobins (Igs), anchored to and secreted by B cells. These molecules are equipped with pockets that bind with remarkable selectivity to a specific antigen. Our bodies maintain an estimated 1014 specificities for Igs and a whopping 1018 for TCRs. Considering our entire genome harbors approximately 105 genes, how is this diversity achieved?..Read more

In this movie neurologist Per Svenningsson at Karolinska Institute explains how 3D visualization of the brain using light-sheet microscopy can be used to better understand Parkinson´s disease...Read more

In a publication in Clinical Proteomics a novel orthogonal strategy based on affinity proteomics and mass spectrometry was used for analytical validation of biomarkers in longitudinally collected serum samples from Duchenne muscular dystrophy (DMD) patients...Read more

The Prostate Cancer Awareness Month and the Movember movement come together in a powerful and united front against one of the most prevalent men's health issues. Throughout November, individuals around the world grow mustaches, participate in events, and engage in conversations to raise awareness about prostate cancer and men's mental health...Read more

Tight junctions are cell-cell contacts formed at the apical-most part of the lateral membrane between polarized cells and are important players in maintaining the homeostasis and the integrity of epithelia and endothelia. Claudin-3 is one of the central components in tight junction complexes...Read more