The latest news from the Human Protein Atlas.https://www.proteinatlas.org/newsA new article in Protein Science describes the HPA Multiplex tissue resource, a spatial proteomics effort adding a new layer of high-resolution protein expression data to the HPA portal. The article presents both the methodology and the biological value of the resource, providing a scalable framework for in-depth spatial proteomics profiling of human tissues.https://www.proteinatlas.org/news/2026-08-27/the-multiplex-tissue-resource-provides-deeper-spatial-insight-into-protein-expressionThu, 27 Aug 2026 00:00:00Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder associated with high morbidity and early mortality. Rapidly progressive cell death of upper and lower motor neurons in the brain as well as in the spinal cord leads to loss of voluntary muscle control. Within a few years of diagnosis, patients lose the ability to move, speak, eat and breath without mechanical support. There is no cure for ALS, with current treatments merely aiming at slowing disease progression and improving symptoms.https://www.proteinatlas.org/news/2026-08-20/a-protein-in-the-wrong-place-can-be-catastrophicThu, 20 Aug 2026 00:00:00A recent Molecular Systems Biology study used exploratory spatial proteomics to investigate early changes in high-grade serous ovarian cancer, including precursor lesions in the fallopian tube. In this interview by Gustav Ceder, Dr Fabian Coscia and Dr Mihnea-Paul Dragomir discuss how the team moved from spatial proteomics discovery to tissue-based validation using an Atlas Antibodies / Human Protein Atlas antibody against DHCR7.https://www.proteinatlas.org/news/2026-08-13/from-spatial-proteomics-to-tissue-validation-dhcr7-in-early-ovarian-cancerThu, 13 Aug 2026 00:00:00An article in PNAS describes how hypoxia and the elimination of peroxisomes drives HCC dedifferentiation, a hallmark of malignancy and a challenge for therapy. The E3 ubiquitin ligase RNF126 is identified as a hypoxia-inducible switch that determines peroxisomal fate and links the hypoxic microenvironment to loss of hepatocyte differentiation.https://www.proteinatlas.org/news/2026-08-04/rnf126-and-the-dedifferentiation-of-liver-cancerTue, 4 Aug 2026 00:00:00The multiplex tissue image of this month showcases the spatial expression pattern of acinar cell-regulating basic helix-loop-helix family member a15 (gene: BHLHA15) in exocrine glandular structures of the salivary gland.https://www.proteinatlas.org/news/2026-07-31/multiplex-tissue-image-of-the-month-bhlha15-in-salivary-glandFri, 31 Jul 2026 00:00:00