Movember: Shedding Light on Prostate Cancer Awareness with Immunohistochemistry


The Prostate Cancer Awareness Month and the Movember movement come together in a powerful and united front against one of the most prevalent men's health issues. Throughout November, individuals around the world grow mustaches, participate in events, and engage in conversations to raise awareness about prostate cancer and men's mental health.

Prostate cancer is the second most common cancer among men worldwide, making it a matter of high importance. Raising awareness about this condition is essential to encourage development of methods for early detection, proper management, and better outcomes for those affected. One of the most significant challenges associated with prostate cancer is its silent progression. Symptoms often appear in advanced stages when the cancer has already spread. Prostate cancer awareness campaigns educate men about risk factors, symptoms, and the importance of regular screenings. Early detection can be a lifesaver, as the cancer is often curable when caught in its initial stages. The prostate is a complex structure composed of prostatic glands and a non-glandular stroma. Within the glandular components, secretory cells are the key players, separated from the stroma by a basement membrane and a layer of basal cells. The stroma is made up of fibromuscular tissues that provide support, as well as the necessary blood vessels and nerves.

Understanding the molecular intricacies of prostate cancer has led to the identification of various proteins and biomarkers that play a pivotal role in its diagnosis and management. One protein in the kallikrein protein family worth mentioning is KLK3, commonly referred to as prostate-specific antigen (PSA). PSA is a serine protease synthesized by the glandular cells of the prostate. Its primary function under normal conditions is to aid in the liquefaction of seminal fluid in the seminal coagulum, facilitating the free movement of sperm. However, it's important to note that in cases of prostate cancer and other prostate-related disorders, the serum levels of PSA often become elevated. This is what makes PSA a widely recognized and utilized biomarker for the early detection of prostate cancer in patients. In the image we can observe the expression of the PSA protein in prostate glands.

More information about the prostate can be found here!