Expression of ACTB in melanoma - The Human Protein Atlas

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MELANOMA - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

ACTB is not prognostic in melanoma

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 1415.16
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
3-year survival highⁱ N/A
3-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

1771.1

Number of samples

102

Samples

Sample	Description	FPKM
TCGA-EB-A3Y7-01A	86 years, female, white, stage:iiib, dead, 326 days	4220.9
TCGA-XV-AAZY-01A	76 years, female, white, stage:iiic, alive, 405 days	3907.5
TCGA-BF-A5EO-01A	65 years, male, white, stage:iic, alive, 703 days	3211.3
TCGA-GN-A26C-01A	77 years, male, white, stage:iiic, dead, 821 days	2928.1
TCGA-IH-A3EA-01A	61 years, male, white, stage:iic, alive, 524 days	2927.6
TCGA-BF-A1PU-01A	46 years, female, white, stage:iic, alive, 387 days	2891.4
TCGA-BF-A5ER-01A	63 years, male, white, stage:iic, alive, 327 days	2884.6
TCGA-BF-A5ES-01A	76 years, female, white, stage:iic, alive, 490 days	2871.8
TCGA-BF-AAP7-01A	76 years, female, white, stage:iic, alive, 318 days	2825.1
TCGA-EB-A1NK-01A	48 years, male, white, stage:iic, alive, 1039 days	2800.2
TCGA-ER-A2NB-01A	57 years, male, white, stage:iiib, dead, 857 days	2776.5
TCGA-EB-A5SF-01A	78 years, female, white, stage:iic, dead, 369 days	2700.4
TCGA-BF-A3DL-01A	84 years, female, white, stage:iiib, alive, 769 days	2628.6
TCGA-EB-A97M-01A	66 years, male, white, stage:iic, alive, 414 days	2505.5
TCGA-GN-A263-01A	24 years, male, white, stage:iv, dead, 467 days	2464.0
TCGA-EB-A3XC-01A	74 years, male, white, stage:iic, alive, 650 days	2336.1
TCGA-EB-A82B-01A	58 years, female, asian, stage:iii, alive, 390 days	2323.6
TCGA-ER-A196-01A	64 years, female, white, stage:iic, alive, 1785 days	2297.3
TCGA-BF-AAOU-01A	73 years, female, white, stage:iic, alive, 476 days	2267.6
TCGA-BF-A1PV-01A	74 years, female, white, stage:iic, alive, 14 days	2210.6
TCGA-BF-A1PX-01A	56 years, male, white, stage:iiib, dead, 282 days	2204.3
TCGA-EB-A42Y-01A	73 years, female, asian, stage:iic, dead, 721 days	2190.3
TCGA-EB-A553-01A	62 years, male, white, stage:iic, alive, 226 days	2154.3
TCGA-EB-A44O-01A	69 years, male, white, stage:iib, alive, 81 days	2137.0
TCGA-EB-A4OZ-01A	42 years, female, white, stage:iiic, alive, 620 days	2114.1
TCGA-EB-A3XD-01A	53 years, female, white, stage:iic, alive, 1160 days	2085.5
TCGA-ER-A42H-01A	77 years, male, white, dead, 426 days	2070.4
TCGA-BF-A1Q0-01A	80 years, male, white, stage:iic, alive, 831 days	2065.5
TCGA-EB-A57M-01A	56 years, male, asian, stage:iiib, dead, 472 days	2032.7
TCGA-YG-AA3N-01A	67 years, male, stage:iic, alive, 306 days	2032.3
TCGA-BF-A9VF-01A	77 years, male, white, stage:iic, alive, 440 days	2016.2
TCGA-EB-A85J-01A	66 years, female, white, stage:iib, alive, 360 days	2015.4
TCGA-EB-A3XE-01A	77 years, female, white, stage:iia, alive, 180 days	1929.1
TCGA-XV-AAZW-01A	62 years, female, white, stage:ii, dead, 393 days	1926.9
TCGA-EB-A4IQ-01A	42 years, female, asian, stage:iiib, dead, 636 days	1923.0
TCGA-EB-A3XF-01A	57 years, male, white, stage:iic, alive, 278 days	1916.4
TCGA-XV-AAZV-01A	56 years, female, white, stage:ii, alive, 412 days	1910.3
TCGA-GF-A2C7-01A	48 years, male, white, stage:iic, alive, 21 days	1887.6
TCGA-EB-A85I-01A	66 years, male, white, stage:iic, alive, 362 days	1822.1
TCGA-FR-A2OS-01A	49 years, female, white, stage:iic, dead, 368 days	1819.8
TCGA-EB-A3HV-01A	37 years, male, white, stage:iic, alive, 39 days	1818.1
TCGA-EB-A4OY-01A	65 years, female, white, stage:iiib, alive, 977 days	1781.7
TCGA-BF-A5EQ-01A	63 years, male, white, stage:iic, alive, 323 days	1780.5
TCGA-DA-A960-01A	73 years, male, white, stage:iib, alive, 804 days	1780.2
TCGA-EB-A6QZ-01A	76 years, female, white, stage:iia, dead, 352 days	1740.1
TCGA-BF-AAP1-01A	86 years, male, white, stage:iic, alive, 409 days	1722.1
TCGA-EB-A82C-01A	70 years, female, asian, stage:iic, alive, 17 days	1721.3
TCGA-XV-A9W2-01A	81 years, male, white, stage:i, alive, 417 days	1710.6
TCGA-EB-A51B-01A	53 years, male, white, stage:iic, alive, 931 days	1653.8
TCGA-EB-A4IS-01A	77 years, male, white, stage:iib, alive, 774 days	1624.4
TCGA-FR-A726-01A	90 years, male, white, stage:iic, dead, 305 days	1616.0
TCGA-FR-A728-01A	54 years, female, white, stage:iiib, alive, 583 days	1607.4
TCGA-EB-A5VU-01A	56 years, male, asian, stage:iiib, dead, 321 days	1606.8
TCGA-XV-A9W5-01A	51 years, male, white, stage:i/ii nos, alive, 392 days	1592.2
TCGA-EB-A42Z-01A	49 years, male, asian, stage:iiic, alive, 441 days	1573.5
TCGA-EB-A299-01A	63 years, male, white, stage:iia, alive, 378 days	1569.0
TCGA-BF-A1PZ-01A	71 years, female, white, stage:iib, alive, 853 days	1565.2
TCGA-ER-A194-01A	77 years, male, white, dead, 1354 days	1562.5
TCGA-ER-A19K-01A	79 years, female, white, stage:iic, dead, 469 days	1558.0
TCGA-GN-A8LN-01A	68 years, male, white, stage:iic, alive, 772 days	1553.0
TCGA-EB-A44N-01A	59 years, male, white, stage:iic, dead, 205 days	1545.4
TCGA-BF-A3DJ-01A	36 years, female, white, stage:iiib, alive, 464 days	1533.3
TCGA-GN-A4U5-01A	61 years, female, white, stage:ib, alive, 1156 days	1523.3
TCGA-FR-A3R1-01A	69 years, male, white, stage:iic, alive, 685 days	1508.9
TCGA-BF-AAP4-01A	61 years, male, white, stage:iic, alive, 335 days	1506.2
TCGA-FW-A5DX-01A	71 years, male, white, stage:iiic, alive, 640 days	1506.1
TCGA-BF-A5EP-01A	75 years, female, white, stage:iiic, alive, 335 days	1483.4
TCGA-EB-A44P-01A	58 years, female, white, stage:iic, alive, 741 days	1479.3
TCGA-BF-A3DN-01A	81 years, female, white, stage:iiic, alive, 717 days	1445.4
TCGA-HR-A5NC-01A	90 years, female, alive, 1000 days	1440.2
TCGA-BF-A3DM-01A	63 years, male, white, stage:iia, alive, 601 days	1428.0
TCGA-EB-A3Y6-01A	56 years, female, white, stage:iic, alive, 126 days	1402.3
TCGA-EB-A4P0-01A	82 years, male, white, stage:iic, dead, 326 days	1393.2
TCGA-BF-AAOX-01A	83 years, male, white, stage:iic, alive, 444 days	1330.8
TCGA-EB-A5FP-01A	65 years, female, white, stage:iv, dead, 454 days	1323.6
TCGA-EB-A550-01A	75 years, female, white, stage:iic, dead, 264 days	1313.8
TCGA-EB-A551-01A	78 years, female, white, stage:iiic, alive, 590 days	1305.8
TCGA-EB-A6QY-01A	71 years, male, white, stage:iic, alive, 382 days	1272.1
TCGA-GF-A769-01A	39 years, male, white, stage:iic, dead, 1070 days	1260.0
TCGA-WE-A8K4-01A	85 years, male, white, stage:iib, alive, 614 days	1243.6
TCGA-FS-A1ZN-01A	43 years, male, white, stage:iiia, dead, 730 days	1242.1
TCGA-EB-A3XB-01A	63 years, male, white, stage:ii, alive, 796 days	1239.5
TCGA-EB-A4XL-01A	56 years, female, white, stage:iic, alive, 777 days	1234.1
TCGA-EB-A24D-01A	72 years, male, white, stage:iiib, alive, 645 days	1207.5
TCGA-BF-AAP2-01A	62 years, male, white, stage:iib, alive, 405 days	1197.2
TCGA-EB-A5UM-01A	48 years, female, white, stage:iic, alive, 779 days	1187.7
TCGA-EB-A41A-01A	90 years, male, white, stage:iic, alive, 262 days	1176.4
TCGA-D3-A5GT-01A	43 years, male, white, stage:iiic, alive, 487 days	1168.8
TCGA-EB-A6R0-01A	58 years, female, white, stage:iic, dead, 608 days	1123.5
TCGA-D9-A3Z4-01A	54 years, male, white, stage:iiic, dead, 519 days	1121.7
TCGA-BF-AAP6-01A	55 years, male, white, stage:iii, alive, 325 days	1106.4
TCGA-D9-A4Z5-01A	68 years, male, white, stage:iib, alive, 218 days	1067.8
TCGA-ER-A19T-01A	51 years, male, white, stage:iv, dead, 270 days	1051.7
TCGA-ER-A2NF-01A	53 years, male, white, stage:iiib, dead, 877 days	985.0
TCGA-BF-AAP8-01A	58 years, male, white, stage:iic, alive, 447 days	982.5
TCGA-D9-A4Z2-01A	50 years, male, white, stage:iiic, dead, 190 days	951.7
TCGA-EB-A24C-01A	56 years, male, white, alive, 632 days	931.6
TCGA-EB-A5SE-01A	73 years, male, white, stage:iib, dead, 401 days	888.4
TCGA-XV-A9VZ-01A	90 years, female, white, stage:ii, alive, 11 days	844.0
TCGA-EB-A41B-01A	76 years, female, white, stage:iic, alive, 291 days	837.6
TCGA-EB-A431-01A	34 years, male, white, stage:iic, alive, 568 days	789.6
TCGA-D9-A4Z3-01A	73 years, female, white, stage:iiic, alive, 505 days	714.0
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MELANOMA - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA041264	Antibody HPA041271	Antibody CAB002621
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.