Cell type atlas - ACTB - The Human Protein Atlas

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ACTB

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ACTB
Gene descriptionⁱ Full gene name according to HGNC.	Actin beta
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	11

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	1069 NX
Lung	1069 NX

Alveolar cells type 2	822 NX
Lung	822 NX

B-cells	2485 NX
Kidney	4643 NX
Liver	2485 NX
Colon	1048 NX

Basal glandular cells	7354 NX
Prostate	7354 NX

Basal keratinocytes	5096 NX
Skin	5096 NX

Bipolar cells	156 NX
Eye	156 NX

Cardiomyocytes	125 NX
Heart muscle	125 NX

Cholangiocytes	1203 NX
Liver	1203 NX

Ciliated cells	478 NX
Lung	478 NX

Club cells	624 NX
Lung	624 NX

Collecting duct cells	2034 NX
Kidney	2034 NX

Cone photoreceptor cells	81 NX
Eye	81 NX

Cytotrophoblasts	3302 NX
Placenta	3302 NX

Distal tubular cells	1930 NX
Kidney	1930 NX

Ductal cells	6734 NX
Pancreas	6734 NX

Early spermatids	80 NX
Testis	80 NX

Endothelial cells	1836 NX
Pancreas	5540 NX
Placenta	4569 NX
Skin	2956 NX
Prostate	1992 NX
Eye	1836 NX
Testis	1642 NX
Liver	1589 NX
Lung	805 NX
Heart muscle	202 NX

Enterocytes	3282 NX
Small intestine	4256 NX
Rectum	3977 NX
Colon	2016 NX

Erythroid cells	1028 NX
Liver	1028 NX

Exocrine glandular cells	5553 NX
Pancreas	5553 NX

Extravillous trophoblasts	10237 NX
Placenta	10237 NX

Fibroblasts	3326 NX
Placenta	5428 NX
Skin	3626 NX
Prostate	1546 NX
Lung	820 NX
Heart muscle	203 NX

Glandular cells	3646 NX
Prostate	3646 NX

Granulocytes	1466 NX
Lung	2042 NX
Colon	891 NX

Hepatocytes	2345 NX
Liver	2345 NX

Hofbauer cells	12685 NX
Placenta	12685 NX

Horizontal cells	254 NX
Eye	254 NX

Intestinal endocrine cells	1395 NX
Rectum	1676 NX
Colon	1115 NX

Ito cells	2304 NX
Liver	2304 NX

Kupffer cells	7427 NX
Liver	7427 NX

Late spermatids	112 NX
Testis	112 NX

Leydig cells	1636 NX
Testis	1636 NX

Macrophages	7667 NX
Pancreas	11787 NX
Kidney	11391 NX
Skin	11364 NX
Prostate	5373 NX
Testis	4724 NX
Lung	2191 NX

Melanocytes	2841 NX
Skin	2841 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	32742 NX
Pancreas	32742 NX

Mucus-secreting cells	1862 NX
Small intestine	2023 NX
Colon	1795 NX
Rectum	1658 NX

Muller glia cells	1551 NX
Eye	1551 NX

Pancreatic endocrine cells	9574 NX
Pancreas	9573 NX

Paneth cells	2795 NX
Colon	2905 NX
Small intestine	2795 NX
Rectum	2158 NX

Peritubular cells	2520 NX
Testis	2520 NX

Proximal tubular cells	1484 NX
Kidney	1484 NX

Rod photoreceptor cells	126 NX
Eye	126 NX

Sertoli cells	3234 NX
Testis	3234 NX

Smooth muscle cells	4447 NX
Pancreas	11360 NX
Skin	4628 NX
Prostate	4447 NX
Heart muscle	700 NX

Spermatocytes	80 NX
Testis	80 NX

Spermatogonia	346 NX
Testis	346 NX

Suprabasal keratinocytes	4128 NX
Skin	4128 NX

Syncytiotrophoblasts	2724 NX
Placenta	2724 NX

T-cells	5423 NX
Kidney	8582 NX
Skin	6926 NX
Liver	5434 NX
Prostate	2842 NX
Lung	1888 NX
Colon	1111 NX

Undifferentiated cells	1783 NX
Small intestine	2527 NX
Rectum	1553 NX
Colon	1313 NX

Urothelial cells	5007 NX
Prostate	5007 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.