Expression of POLR2K in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 36.68
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

27.7

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	68.4
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	56.1
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	55.0
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	54.4
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	53.1
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	50.2
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	49.1
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	47.6
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	47.2
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	47.0
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	45.2
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	45.2
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	45.0
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	44.5
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	43.7
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	43.6
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	42.8
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	42.4
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	41.1
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	41.0
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	40.9
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	39.9
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	39.3
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	39.0
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	38.7
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	37.8
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	37.7
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	37.6
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	37.5
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	37.3
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	37.0
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	36.7
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	36.7
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	36.2
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	35.6
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	35.3
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	35.2
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	35.0
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	34.8
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	34.7
TCGA-CL-4957-01A	79 years, female, dead, 425 days	34.5
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	34.4
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	34.2
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	34.2
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	34.0
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	33.8
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	33.3
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	33.3
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	33.2
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	33.1
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	32.9
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	32.7
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	32.7
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	32.5
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	32.3
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	32.1
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	32.1
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	32.0
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	31.7
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	31.6
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	31.5
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	30.9
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	30.7
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	30.7
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	30.7
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	30.7
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	30.5
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	30.2
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	29.9
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	29.5
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	28.9
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	28.3
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	27.7
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	27.5
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	27.5
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	27.5
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	27.0
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	26.9
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	26.7
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	26.5
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	26.4
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	26.3
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	26.1
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	26.1
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	25.8
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	25.6
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	25.6
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	25.0
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	24.8
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	24.8
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	24.5
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	24.3
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	24.3
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	24.0
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	23.7
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	23.6
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	23.5
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	23.1
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	23.1
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	23.0
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	22.9
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	22.8
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	22.7
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	22.6
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	22.1
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	22.1
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	21.6
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	21.6
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	21.5
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	21.4
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	21.4
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	21.0
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	20.7
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	20.5
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	20.1
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	19.6
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	19.4
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	19.1
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	19.1
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	19.1
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	19.1
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	18.9
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	18.7
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	18.5
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	18.0
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	18.0
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	17.7
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	17.6
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	17.5
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	17.4
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	17.1
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	17.0
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	17.0
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	16.8
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	16.8
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	16.1
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	16.1
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	15.9
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	15.8
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	15.1
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	15.0
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	15.0
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	14.9
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	14.8
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	14.4
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	14.2
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	13.8
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	13.8
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	13.3
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	12.6
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	11.9
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	11.2
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	11.1
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	10.0
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	8.3
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	5.1
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	4.3
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	2.7
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	2.4
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