Cell type atlas - POLR2K - The Human Protein Atlas

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POLR2K

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLR2K
Gene descriptionⁱ Full gene name according to HGNC.	RNA polymerase II subunit K
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	RNA polymerase related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	63 NX
Lung	63 NX

Alveolar cells type 2	53 NX
Lung	53 NX

B-cells	109 NX
Kidney	111 NX
Colon	108 NX
Liver	76 NX

Basal glandular cells	131 NX
Prostate	131 NX

Basal keratinocytes	145 NX
Skin	145 NX

Bipolar cells	56 NX
Eye	56 NX

Cardiomyocytes	83 NX
Heart muscle	83 NX

Cholangiocytes	79 NX
Liver	79 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	47 NX
Lung	47 NX

Collecting duct cells	140 NX
Kidney	140 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	120 NX
Placenta	120 NX

Distal tubular cells	373 NX
Kidney	373 NX

Ductal cells	129 NX
Pancreas	129 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	101 NX
Prostate	135 NX
Placenta	126 NX
Skin	125 NX
Pancreas	125 NX
Heart muscle	96 NX
Testis	81 NX
Lung	67 NX
Liver	61 NX
Eye	56 NX

Enterocytes	83 NX
Small intestine	91 NX
Colon	83 NX
Rectum	60 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	114 NX
Pancreas	114 NX

Extravillous trophoblasts	160 NX
Placenta	160 NX

Fibroblasts	122 NX
Prostate	149 NX
Placenta	148 NX
Skin	121 NX
Heart muscle	87 NX
Lung	38 NX

Glandular cells	170 NX
Prostate	170 NX

Granulocytes	108 NX
Colon	147 NX
Lung	70 NX

Hepatocytes	111 NX
Liver	111 NX

Hofbauer cells	134 NX
Placenta	134 NX

Horizontal cells	46 NX
Eye	46 NX

Intestinal endocrine cells	117 NX
Colon	129 NX
Rectum	105 NX

Ito cells	79 NX
Liver	79 NX

Kupffer cells	67 NX
Liver	67 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	108 NX
Testis	108 NX

Macrophages	92 NX
Pancreas	140 NX
Kidney	132 NX
Skin	93 NX
Prostate	92 NX
Testis	90 NX
Lung	60 NX

Melanocytes	130 NX
Skin	130 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	180 NX
Pancreas	180 NX

Mucus-secreting cells	83 NX
Colon	151 NX
Small intestine	85 NX
Rectum	76 NX

Muller glia cells	71 NX
Eye	71 NX

Pancreatic endocrine cells	121 NX
Pancreas	121 NX

Paneth cells	72 NX
Rectum	74 NX
Colon	72 NX
Small intestine	49 NX

Peritubular cells	114 NX
Testis	114 NX

Proximal tubular cells	283 NX
Kidney	283 NX

Rod photoreceptor cells	42 NX
Eye	42 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	125 NX
Prostate	143 NX
Pancreas	132 NX
Skin	124 NX
Heart muscle	91 NX

Spermatocytes	125 NX
Testis	125 NX

Spermatogonia	166 NX
Testis	166 NX

Suprabasal keratinocytes	149 NX
Skin	149 NX

Syncytiotrophoblasts	115 NX
Placenta	115 NX

T-cells	122 NX
Prostate	244 NX
Skin	209 NX
Kidney	152 NX
Colon	140 NX
Liver	83 NX
Lung	50 NX

Undifferentiated cells	78 NX
Colon	145 NX
Rectum	76 NX
Small intestine	72 NX

Urothelial cells	236 NX
Prostate	236 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.