Expression of IGFBP4 in pancreatic cancer

PANCREATIC CANCER - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

IGFBP4 is not prognostic in pancreatic cancer

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 330.2
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

387.4

Number of samples

176

Samples

Sample	Description	FPKM
TCGA-HZ-8001-01A	69 years, male, white, stage:iii, alive, 706 days	1424.4
TCGA-IB-AAUV-01A	49 years, male, white, stage:iib, alive, 404 days	1199.2
TCGA-HZ-A77P-01A	77 years, male, white, stage:iib, alive, 330 days	1108.8
TCGA-HZ-7920-01A	71 years, male, white, stage:ib, dead, 236 days	1065.7
TCGA-RL-AAAS-01A	60 years, female, white, stage:ib, alive, 9 days	1058.4
TCGA-HZ-A77Q-01A	55 years, female, white, stage:iib, alive, 33 days	1023.5
TCGA-XN-A8T5-01A	53 years, female, white, stage:ib, alive, 720 days	975.4
TCGA-IB-AAUS-01A	84 years, female, white, stage:iib, alive, 225 days	961.0
TCGA-FB-A5VM-01A	74 years, male, white, stage:ib, dead, 498 days	949.5
TCGA-IB-AAUR-01A	67 years, male, white, stage:iib, alive, 338 days	908.2
TCGA-US-A77J-01A	81 years, female, white, stage:iib, dead, 568 days	861.8
TCGA-XD-AAUH-01A	57 years, female, white, stage:iib, alive, 395 days	835.3
TCGA-HZ-A49H-01A	68 years, female, white, stage:iib, alive, 491 days	814.3
TCGA-FB-A7DR-01A	48 years, male, asian, stage:iia, dead, 353 days	747.2
TCGA-2J-AABI-01A	55 years, female, white, stage:iia, alive, 969 days	732.1
TCGA-XD-AAUG-01A	66 years, female, white, stage:iv, alive, 420 days	731.7
TCGA-2J-AABA-01A	55 years, male, white, stage:iib, dead, 607 days	711.4
TCGA-IB-A5ST-01A	64 years, female, white, stage:iib, alive, 635 days	702.4
TCGA-2J-AABP-01A	58 years, female, white, stage:iib, alive, 463 days	674.3
TCGA-HZ-7925-01A	66 years, male, white, stage:iib, dead, 614 days	668.8
TCGA-FB-AAPS-01A	62 years, female, white, stage:iib, alive, 228 days	664.0
TCGA-IB-7888-01A	66 years, female, black or african american, stage:iia, dead, 1332 days	653.3
TCGA-FB-A4P5-01A	69 years, female, white, stage:iib, dead, 179 days	642.5
TCGA-HZ-8002-01A	61 years, male, white, stage:iib, dead, 366 days	605.9
TCGA-3A-A9IX-01A	40 years, male, white, stage:ia, alive, 1037 days	594.9
TCGA-3A-A9IN-01A	62 years, female, white, stage:ib, alive, 2084 days	568.7
TCGA-F2-7273-01A	54 years, male, black or african american, stage:iib, dead, 592 days	559.6
TCGA-H6-A45N-01A	88 years, female, white, stage:iib, dead, 421 days	558.5
TCGA-2L-AAQA-01A	76 years, male, white, stage:iib, dead, 143 days	556.6
TCGA-IB-7645-01A	44 years, female, stage:iib, dead, 1502 days	547.0
TCGA-OE-A75W-01A	75 years, male, white, stage:iia, dead, 267 days	540.6
TCGA-2L-AAQL-01A	82 years, male, white, stage:iib, dead, 292 days	535.0
TCGA-IB-A5SO-01A	71 years, male, white, stage:iib, dead, 365 days	528.7
TCGA-HZ-7923-01A	65 years, male, white, stage:iia, alive, 314 days	523.0
TCGA-IB-7897-01A	54 years, female, white, stage:iib, dead, 486 days	518.2
TCGA-US-A774-01A	76 years, female, white, stage:iib, dead, 695 days	515.0
TCGA-2J-AABO-01A	43 years, male, white, stage:iib, alive, 440 days	511.8
TCGA-HZ-8519-01A	73 years, male, white, stage:ia, alive, 454 days	510.4
TCGA-YH-A8SY-01A	73 years, female, white, alive, 388 days	509.2
TCGA-XD-AAUI-01A	50 years, female, white, stage:iib, dead, 366 days	498.9
TCGA-3E-AAAY-01A	67 years, male, white, stage:iib, alive, 2285 days	494.2
TCGA-2J-AABT-01A	72 years, female, white, stage:iib, alive, 319 days	485.0
TCGA-3A-A9IC-01A	61 years, female, white, stage:iib, dead, 738 days	477.0
TCGA-FB-AAQ3-01A	65 years, female, white, stage:iib, dead, 31 days	475.4
TCGA-IB-AAUW-01A	63 years, female, white, stage:iib, dead, 230 days	462.7
TCGA-YB-A89D-01A	59 years, male, white, stage:iib, alive, 350 days	459.0
TCGA-3A-A9IB-01A	69 years, female, white, stage:iib, dead, 224 days	458.5
TCGA-IB-7890-01A	73 years, male, stage:ib, dead, 598 days	452.9
TCGA-IB-A5SQ-01A	56 years, female, white, stage:ib, dead, 219 days	448.2
TCGA-F2-7276-01A	64 years, male, white, stage:iib, dead, 216 days	446.6
TCGA-2J-AABR-01A	60 years, female, white, stage:iia, alive, 438 days	444.6
TCGA-HV-AA8V-01A	50 years, male, asian, stage:iib, alive, 920 days	443.5
TCGA-HZ-A4BH-01A	75 years, male, white, stage:iib, alive, 194 days	438.0
TCGA-3E-AAAZ-01A	71 years, male, white, stage:iia, dead, 2182 days	430.7
TCGA-IB-7893-01A	64 years, male, white, stage:iia, dead, 117 days	418.2
TCGA-Q3-A5QY-01A	58 years, male, white, stage:iib, alive, 416 days	411.2
TCGA-IB-AAUQ-01A	50 years, male, white, stage:iib, dead, 183 days	408.8
TCGA-IB-7646-01A	60 years, male, white, stage:iib, dead, 145 days	407.2
TCGA-2J-AAB8-01A	71 years, male, white, stage:iib, alive, 80 days	406.4
TCGA-FB-AAPZ-01A	54 years, male, white, stage:iib, alive, 716 days	405.9
TCGA-IB-AAUP-01A	68 years, male, white, stage:iib, alive, 431 days	403.8
TCGA-HV-A5A6-01A	65 years, female, asian, stage:iib, dead, 2036 days	401.3
TCGA-HZ-A49G-01A	58 years, female, white, stage:iib, alive, 660 days	400.1
TCGA-HV-A7OL-01A	70 years, male, asian, stage:iia, alive, 252 days	399.5
TCGA-2J-AAB1-01A	65 years, male, white, stage:iib, dead, 66 days	399.3
TCGA-HZ-8317-01A	69 years, female, white, stage:iib, dead, 378 days	397.9
TCGA-3A-A9J0-01A	75 years, male, white, stage:iib, alive, 743 days	395.3
TCGA-2J-AABH-01A	61 years, male, white, stage:iia, alive, 1287 days	391.9
TCGA-2J-AAB9-01A	71 years, female, white, stage:iib, dead, 627 days	390.7
TCGA-IB-AAUT-01A	65 years, male, white, stage:iib, alive, 287 days	389.9
TCGA-FB-A4P6-01A	54 years, male, white, stage:iib, alive, 767 days	381.7
TCGA-HZ-A4BK-01A	72 years, male, white, stage:iib, alive, 657 days	362.6
TCGA-3A-A9IV-01A	59 years, female, white, stage:ib, alive, 1103 days	357.8
TCGA-HZ-A49I-01A	77 years, male, white, stage:iib, dead, 308 days	356.6
TCGA-3A-A9IZ-01A	47 years, male, white, stage:iib, dead, 308 days	354.2
TCGA-2J-AAB6-01A	75 years, male, white, stage:iia, dead, 293 days	348.7
TCGA-IB-A7M4-01A	81 years, male, white, stage:iib, alive, 483 days	347.3
TCGA-PZ-A5RE-01A	44 years, female, white, stage:iib, dead, 470 days	347.0
TCGA-3A-A9I7-01A	45 years, male, black or african american, stage:iib, alive, 1323 days	346.2
TCGA-RB-AA9M-01A	43 years, male, white, stage:iib, alive, 286 days	342.4
TCGA-2J-AABE-01A	73 years, male, white, stage:iia, alive, 676 days	341.2
TCGA-2L-AAQJ-01A	49 years, female, white, stage:iii, dead, 394 days	341.1
TCGA-FB-AAPY-01A	71 years, male, white, stage:iib, dead, 1059 days	338.5
TCGA-XN-A8T3-01A	67 years, male, white, stage:ib, alive, 951 days	336.9
TCGA-US-A779-01A	54 years, female, white, stage:iib, dead, 511 days	335.8
TCGA-3A-A9I5-01A	58 years, male, white, alive, 1794 days	335.2
TCGA-IB-7885-01A	78 years, female, white, stage:iib, alive, 1257 days	331.4
TCGA-IB-7889-01A	86 years, female, white, stage:iib, dead, 481 days	329.0
TCGA-HZ-8315-01A	54 years, female, white, stage:iia, dead, 299 days	324.4
TCGA-2J-AABF-01A	73 years, male, white, stage:iib, dead, 691 days	322.9
TCGA-HZ-7922-01A	61 years, female, white, stage:iib, alive, 4 days	322.9
TCGA-H6-8124-01A	56 years, female, white, stage:iib, alive, 392 days	319.8
TCGA-IB-7649-01A	73 years, female, stage:iib, dead, 467 days	313.7
TCGA-IB-AAUU-01A	35 years, male, white, stage:iib, alive, 245 days	310.8
TCGA-Z5-AAPL-01A	74 years, female, white, stage:iia, alive, 467 days	308.2
TCGA-IB-AAUN-01A	74 years, female, white, stage:ib, dead, 144 days	307.0
TCGA-F2-A8YN-01A	76 years, male, white, stage:iia, alive, 517 days	306.2
TCGA-XD-AAUL-01A	56 years, male, white, stage:iia, alive, 498 days	305.9
TCGA-HZ-7919-01A	52 years, female, white, stage:iib, dead, 593 days	304.8
TCGA-US-A77E-01A	73 years, male, white, stage:iib, dead, 430 days	300.9
TCGA-IB-A6UG-01A	65 years, male, white, stage:iib, dead, 41 days	299.4
TCGA-IB-7887-01A	62 years, female, white, stage:iib, dead, 110 days	297.7
TCGA-HZ-A77O-01A	77 years, female, white, stage:iib, dead, 160 days	296.6
TCGA-2J-AABU-01A	56 years, male, white, stage:iib, dead, 277 days	292.8
TCGA-HZ-A9TJ-01A	70 years, male, white, stage:iv, alive, 603 days	291.7
TCGA-HZ-8638-01A	84 years, female, white, stage:ia, dead, 151 days	290.8
TCGA-S4-A8RP-01A	77 years, female, white, stage:iib, dead, 702 days	286.8
TCGA-HZ-8637-01A	76 years, female, white, stage:iib, dead, 517 days	281.5
TCGA-HV-A5A5-01A	61 years, female, asian, stage:iib, alive, 289 days	278.5
TCGA-HZ-7926-01A	57 years, male, black or african american, stage:iib, dead, 518 days	278.0
TCGA-LB-A7SX-01A	74 years, female, black or african american, stage:iib, dead, 393 days	274.3
TCGA-2L-AAQI-01A	66 years, male, white, stage:iib, dead, 103 days	272.5
TCGA-FB-AAQ6-01A	85 years, male, white, stage:ia, dead, 244 days	272.2
TCGA-IB-7654-01A	80 years, male, white, stage:iib, dead, 476 days	270.8
TCGA-FB-A545-01A	72 years, female, white, stage:iib, dead, 732 days	270.6
TCGA-IB-A5SS-01A	64 years, female, white, stage:iib, dead, 460 days	270.4
TCGA-2J-AAB4-01A	48 years, male, white, stage:iib, alive, 729 days	270.3
TCGA-F2-A7TX-01A	77 years, male, white, stage:iib, dead, 95 days	268.0
TCGA-IB-8126-01A	80 years, female, white, stage:iii, alive, 462 days	267.8
TCGA-HV-A5A4-01A	72 years, female, asian, stage:iia, alive, 232 days	264.2
TCGA-3A-A9IH-01A	66 years, female, white, stage:ia, alive, 1021 days	264.1
TCGA-HZ-8636-01A	58 years, female, white, stage:iv, dead, 545 days	262.1
TCGA-IB-7891-01A	49 years, female, white, stage:iib, dead, 913 days	258.5
TCGA-IB-8127-01A	59 years, male, white, stage:iib, alive, 522 days	256.4
TCGA-HZ-7918-01A	72 years, male, white, stage:iib, alive, 969 days	255.7
TCGA-HV-A7OP-01A	72 years, male, asian, stage:iib, alive, 978 days	253.6
TCGA-FB-AAPQ-01A	65 years, male, white, stage:iib, dead, 1130 days	252.4
TCGA-FB-AAQ0-01A	68 years, male, white, stage:iia, dead, 473 days	251.3
TCGA-Q3-AA2A-01A	64 years, female, white, stage:ib, alive, 95 days	250.7
TCGA-H8-A6C1-01A	53 years, male, white, stage:iia, alive, 671 days	250.0
TCGA-IB-A5SP-01A	77 years, male, white, stage:iia, alive, 482 days	248.7
TCGA-F2-6879-01A	57 years, male, white, stage:iib, dead, 334 days	239.7
TCGA-IB-7886-01A	80 years, male, white, stage:iib, dead, 123 days	238.4
TCGA-F2-A44G-01A	79 years, female, white, stage:iib, dead, 233 days	236.8
TCGA-F2-A44H-01A	65 years, male, white, stage:iia, alive, 586 days	235.4
TCGA-M8-A5N4-01A	48 years, female, stage:iia, alive, 584 days	230.5
TCGA-3A-A9I9-01A	67 years, male, white, stage:iia, dead, 634 days	228.7
TCGA-HV-A5A3-01A	50 years, male, asian, stage:iia, dead, 128 days	227.0
TCGA-YY-A8LH-01A	61 years, female, white, stage:iib, alive, 2016 days	224.2
TCGA-RB-A7B8-01A	81 years, female, white, stage:iib, dead, 466 days	223.5
TCGA-FB-AAQ2-01A	81 years, female, white, stage:iib, dead, 153 days	219.5
TCGA-L1-A7W4-01A	48 years, female, white, stage:iib, dead, 278 days	218.9
TCGA-LB-A8F3-01A	64 years, female, black or african american, stage:iia, alive, 379 days	218.7
TCGA-FB-AAQ1-01A	49 years, male, white, stage:iib, dead, 123 days	218.3
TCGA-IB-AAUM-01A	76 years, male, white, stage:iib, alive, 8 days	216.1
TCGA-IB-7652-01A	49 years, female, asian, stage:iib, alive, 1116 days	214.8
TCGA-2L-AAQE-01A	56 years, male, white, stage:iib, dead, 684 days	210.1
TCGA-HZ-7924-01A	60 years, female, white, stage:iia, alive, 840 days	207.9
TCGA-HV-AA8X-01A	75 years, female, asian, stage:iib, dead, 532 days	204.6
TCGA-S4-A8RO-01A	75 years, female, white, stage:iib, alive, 525 days	202.2
TCGA-2J-AABK-01A	71 years, male, white, stage:iib, alive, 484 days	201.4
TCGA-LB-A9Q5-01A	63 years, female, white, stage:iib, dead, 313 days	197.9
TCGA-2L-AAQM-01A	52 years, male, white, stage:iib, alive, 1383 days	194.0
TCGA-3A-A9IU-01A	65 years, male, white, stage:iib, dead, 458 days	177.4
TCGA-IB-A7LX-01A	57 years, male, white, stage:iib, dead, 250 days	177.3
TCGA-2J-AABV-01A	74 years, male, white, stage:iib, dead, 652 days	174.5
TCGA-IB-7644-01A	65 years, female, white, stage:iv, dead, 394 days	172.6
TCGA-IB-AAUO-01A	64 years, female, white, stage:iib, dead, 239 days	162.9
TCGA-HZ-8005-01A	81 years, male, white, stage:iib, dead, 120 days	161.8
TCGA-HZ-8003-01A	65 years, female, white, stage:iib, dead, 596 days	161.3
TCGA-IB-7651-01A	64 years, female, white, stage:iib, dead, 603 days	152.3
TCGA-US-A77G-01A	64 years, male, white, stage:iib, dead, 12 days	151.8
TCGA-IB-A6UF-01A	63 years, male, white, stage:iib, alive, 666 days	149.9
TCGA-3A-A9IJ-01A	65 years, male, white, stage:ib, alive, 1854 days	149.4
TCGA-FB-A78T-01A	71 years, female, white, stage:iib, dead, 375 days	138.2
TCGA-HZ-A8P1-01A	81 years, male, white, stage:ib, alive, 7 days	136.8
TCGA-S4-A8RM-01A	67 years, male, white, stage:iib, alive, 737 days	130.0
TCGA-FB-AAPU-01A	41 years, female, asian, stage:iia, dead, 381 days	127.2
TCGA-3A-A9IL-01A	39 years, female, white, stage:i, alive, 2741 days	120.1
TCGA-US-A776-01A	61 years, male, white, stage:iia, alive, 1216 days	83.6
TCGA-3A-A9IO-01A	56 years, male, white, alive, 1942 days	75.8
TCGA-F2-6880-01A	70 years, male, white, stage:iib, alive, 289 days	61.0
TCGA-3A-A9IS-01A	67 years, male, white, stage:ib, alive, 998 days	52.1
TCGA-3A-A9IR-01A	64 years, female, white, stage:ib, alive, 1542 days	50.8
TCGA-FB-AAPP-01A	71 years, male, white, stage:iib, dead, 485 days	47.3
TCGA-HZ-7289-01A	77 years, male, white, stage:iib, dead, 661 days	45.4
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PANCREATIC CANCER - Protein expressionⁱ A mouse-over function shows sample information and annotation data. Click on an image to view it in a full screen mode. Samples can be filtered based on level of antibody staining by selecting one or several of the following categories: high, medium, low and not detected. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset.

Antibody stainingⁱ Antibody staining in the annotated cell types in the current human tissue is reported as not detected, low, medium, or high. This score is based on the staining intensity and fraction of stained cells. Read more	Antibody HPA066240
Staining
High
Medium
Low
Not detected
Intensity
Strong
Moderate
Weak
Negative
Quantity
>75%
75%-25%
<25%
None
Location
Nuclear
Cytoplasmic/membranous
Cytoplasmic/membranous,nuclear
None
Click images for details