Cell type atlas - IGFBP4 - The Human Protein Atlas

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IGFBP4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IGFBP4
Gene descriptionⁱ Full gene name according to HGNC.	Insulin like growth factor binding protein 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ito cells, Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cell, MAIT T-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, ASC diff, ASC TERT1, BJ, BJ hTERT+, HSkMC, U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ito cells, Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	44 NX
Lung	44 NX

B-cells	39 NX
Liver	43 NX
Kidney	36 NX
Colon	13 NX

Basal glandular cells	76 NX
Prostate	76 NX

Basal keratinocytes	50 NX
Skin	50 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	15 NX
Heart muscle	15 NX

Cholangiocytes	99 NX
Liver	99 NX

Ciliated cells	8 NX
Lung	8 NX

Club cells	13 NX
Lung	13 NX

Collecting duct cells	7 NX
Kidney	7 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	5 NX
Placenta	5 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	3 NX
Pancreas	3 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	236 NX
Testis	829 NX
Placenta	456 NX
Prostate	440 NX
Skin	353 NX
Liver	236 NX
Heart muscle	230 NX
Lung	123 NX
Pancreas	93 NX
Eye	69 NX

Enterocytes	69 NX
Colon	99 NX
Rectum	82 NX
Small intestine	50 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	2 NX
Pancreas	2 NX

Extravillous trophoblasts	5 NX
Placenta	5 NX

Fibroblasts	103 NX
Prostate	653 NX
Skin	378 NX
Heart muscle	86 NX
Placenta	59 NX
Lung	51 NX

Glandular cells	16 NX
Prostate	16 NX

Granulocytes	2 NX
Lung	5 NX
Colon	0 NX

Hepatocytes	473 NX
Liver	473 NX

Hofbauer cells	206 NX
Placenta	206 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	8 NX
Rectum	9 NX
Colon	7 NX

Ito cells	498 NX
Liver	498 NX

Kupffer cells	44 NX
Liver	44 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	228 NX
Testis	228 NX

Macrophages	15 NX
Skin	64 NX
Prostate	42 NX
Kidney	21 NX
Testis	9 NX
Lung	4 NX
Pancreas	0 NX

Melanocytes	69 NX
Skin	69 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	5 NX
Pancreas	5 NX

Mucus-secreting cells	78 NX
Rectum	95 NX
Colon	75 NX
Small intestine	30 NX

Muller glia cells	4 NX
Eye	4 NX

Pancreatic endocrine cells	23 NX
Pancreas	23 NX

Paneth cells	69 NX
Rectum	114 NX
Colon	69 NX
Small intestine	11 NX

Peritubular cells	111 NX
Testis	111 NX

Proximal tubular cells	154 NX
Kidney	154 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	188 NX
Testis	188 NX

Smooth muscle cells	233 NX
Prostate	646 NX
Skin	249 NX
Pancreas	143 NX
Heart muscle	98 NX

Spermatocytes	2 NX
Testis	2 NX

Spermatogonia	6 NX
Testis	6 NX

Suprabasal keratinocytes	42 NX
Skin	42 NX

Syncytiotrophoblasts	6 NX
Placenta	6 NX

T-cells	14 NX
Skin	52 NX
Prostate	22 NX
Kidney	19 NX
Colon	14 NX
Lung	13 NX
Liver	9 NX

Undifferentiated cells	111 NX
Rectum	115 NX
Colon	111 NX
Small intestine	38 NX

Urothelial cells	67 NX
Prostate	67 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.