Cell type atlas - CWC25 - The Human Protein Atlas

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CWC25

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CWC25
Gene descriptionⁱ Full gene name according to HGNC.	CWC25 spliceosome associated protein homolog
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	66 NX
Lung	66 NX

B-cells	41 NX
Colon	75 NX
Kidney	45 NX
Liver	26 NX

Basal glandular cells	56 NX
Prostate	56 NX

Basal keratinocytes	57 NX
Skin	57 NX

Bipolar cells	36 NX
Eye	36 NX

Cardiomyocytes	17 NX
Heart muscle	17 NX

Cholangiocytes	20 NX
Liver	20 NX

Ciliated cells	43 NX
Lung	43 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	79 NX
Eye	79 NX

Cytotrophoblasts	31 NX
Placenta	31 NX

Distal tubular cells	25 NX
Kidney	25 NX

Ductal cells	24 NX
Pancreas	24 NX

Early spermatids	92 NX
Testis	92 NX

Endothelial cells	38 NX
Prostate	82 NX
Lung	55 NX
Heart muscle	44 NX
Skin	42 NX
Testis	40 NX
Liver	38 NX
Placenta	28 NX
Eye	26 NX
Pancreas	14 NX

Enterocytes	60 NX
Colon	67 NX
Small intestine	50 NX
Rectum	28 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	30 NX
Placenta	30 NX

Fibroblasts	31 NX
Heart muscle	77 NX
Lung	75 NX
Prostate	55 NX
Skin	31 NX
Placenta	23 NX

Glandular cells	43 NX
Prostate	43 NX

Granulocytes	58 NX
Colon	64 NX
Lung	51 NX

Hepatocytes	21 NX
Liver	21 NX

Hofbauer cells	25 NX
Placenta	25 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	40 NX
Colon	54 NX
Rectum	26 NX

Ito cells	34 NX
Liver	34 NX

Kupffer cells	25 NX
Liver	24 NX

Late spermatids	19 NX
Testis	19 NX

Leydig cells	35 NX
Testis	35 NX

Macrophages	34 NX
Lung	62 NX
Kidney	46 NX
Skin	34 NX
Prostate	33 NX
Testis	32 NX
Pancreas	23 NX

Melanocytes	25 NX
Skin	25 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	34 NX
Pancreas	34 NX

Mucus-secreting cells	25 NX
Colon	89 NX
Rectum	25 NX
Small intestine	24 NX

Muller glia cells	32 NX
Eye	32 NX

Pancreatic endocrine cells	24 NX
Pancreas	24 NX

Paneth cells	42 NX
Colon	127 NX
Small intestine	42 NX
Rectum	20 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	22 NX
Kidney	22 NX

Rod photoreceptor cells	46 NX
Eye	46 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	31 NX
Heart muscle	63 NX
Prostate	46 NX
Skin	31 NX
Pancreas	22 NX

Spermatocytes	88 NX
Testis	88 NX

Spermatogonia	31 NX
Testis	31 NX

Suprabasal keratinocytes	67 NX
Skin	67 NX

Syncytiotrophoblasts	66 NX
Placenta	66 NX

T-cells	52 NX
Prostate	78 NX
Colon	73 NX
Lung	55 NX
Skin	53 NX
Kidney	52 NX
Liver	29 NX

Undifferentiated cells	23 NX
Colon	45 NX
Small intestine	25 NX
Rectum	20 NX

Urothelial cells	58 NX
Prostate	58 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.