Cell type atlas - GTF2I - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GTF2I

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GTF2I
Gene descriptionⁱ Full gene name according to HGNC.	General transcription factor IIi
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	75 NX
Lung	75 NX

Alveolar cells type 2	53 NX
Lung	53 NX

B-cells	73 NX
Kidney	89 NX
Liver	73 NX
Colon	28 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	53 NX
Skin	53 NX

Bipolar cells	263 NX
Eye	263 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	194 NX
Liver	194 NX

Ciliated cells	52 NX
Lung	52 NX

Club cells	55 NX
Lung	55 NX

Collecting duct cells	113 NX
Kidney	113 NX

Cone photoreceptor cells	267 NX
Eye	267 NX

Cytotrophoblasts	85 NX
Placenta	85 NX

Distal tubular cells	48 NX
Kidney	48 NX

Ductal cells	123 NX
Pancreas	123 NX

Early spermatids	34 NX
Testis	34 NX

Endothelial cells	79 NX
Eye	137 NX
Liver	117 NX
Testis	101 NX
Placenta	91 NX
Prostate	81 NX
Skin	71 NX
Pancreas	50 NX
Lung	35 NX
Heart muscle	18 NX

Enterocytes	50 NX
Small intestine	118 NX
Rectum	65 NX
Colon	15 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	73 NX
Pancreas	73 NX

Extravillous trophoblasts	51 NX
Placenta	51 NX

Fibroblasts	66 NX
Lung	73 NX
Placenta	72 NX
Skin	65 NX
Prostate	56 NX
Heart muscle	21 NX

Glandular cells	112 NX
Prostate	112 NX

Granulocytes	13 NX
Lung	16 NX
Colon	9 NX

Hepatocytes	85 NX
Liver	85 NX

Hofbauer cells	68 NX
Placenta	68 NX

Horizontal cells	237 NX
Eye	237 NX

Intestinal endocrine cells	108 NX
Rectum	190 NX
Colon	27 NX

Ito cells	117 NX
Liver	117 NX

Kupffer cells	104 NX
Liver	104 NX

Late spermatids	29 NX
Testis	29 NX

Leydig cells	142 NX
Testis	142 NX

Macrophages	50 NX
Testis	85 NX
Kidney	53 NX
Skin	50 NX
Pancreas	49 NX
Prostate	45 NX
Lung	38 NX

Melanocytes	52 NX
Skin	52 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	68 NX
Pancreas	68 NX

Mucus-secreting cells	68 NX
Small intestine	113 NX
Rectum	59 NX
Colon	19 NX

Muller glia cells	193 NX
Eye	193 NX

Pancreatic endocrine cells	109 NX
Pancreas	109 NX

Paneth cells	76 NX
Small intestine	116 NX
Rectum	76 NX
Colon	3 NX

Peritubular cells	181 NX
Testis	181 NX

Proximal tubular cells	84 NX
Kidney	84 NX

Rod photoreceptor cells	174 NX
Eye	174 NX

Sertoli cells	84 NX
Testis	84 NX

Smooth muscle cells	50 NX
Prostate	64 NX
Skin	51 NX
Pancreas	50 NX
Heart muscle	18 NX

Spermatocytes	22 NX
Testis	22 NX

Spermatogonia	38 NX
Testis	38 NX

Suprabasal keratinocytes	80 NX
Skin	80 NX

Syncytiotrophoblasts	60 NX
Placenta	60 NX

T-cells	46 NX
Liver	66 NX
Skin	52 NX
Kidney	44 NX
Colon	24 NX
Lung	22 NX
Prostate	18 NX

Undifferentiated cells	63 NX
Small intestine	88 NX
Rectum	63 NX
Colon	10 NX

Urothelial cells	93 NX
Prostate	93 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.