Cell type atlas - CUX1 - The Human Protein Atlas

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CUX1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CUX1
Gene descriptionⁱ Full gene name according to HGNC.	Cut like homeobox 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	15

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (non-classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	92 NX
Lung	92 NX

Alveolar cells type 2	46 NX
Lung	46 NX

B-cells	28 NX
Colon	43 NX
Kidney	27 NX
Liver	22 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	23 NX
Skin	23 NX

Bipolar cells	54 NX
Eye	53 NX

Cardiomyocytes	101 NX
Heart muscle	101 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	46 NX
Lung	46 NX

Collecting duct cells	38 NX
Kidney	38 NX

Cone photoreceptor cells	65 NX
Eye	65 NX

Cytotrophoblasts	44 NX
Placenta	44 NX

Distal tubular cells	8 NX
Kidney	8 NX

Ductal cells	30 NX
Pancreas	30 NX

Early spermatids	7 NX
Testis	7 NX

Endothelial cells	31 NX
Prostate	65 NX
Lung	61 NX
Heart muscle	48 NX
Eye	43 NX
Testis	31 NX
Skin	31 NX
Placenta	25 NX
Liver	22 NX
Pancreas	11 NX

Enterocytes	50 NX
Colon	73 NX
Rectum	62 NX
Small intestine	36 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	21 NX
Pancreas	21 NX

Extravillous trophoblasts	48 NX
Placenta	48 NX

Fibroblasts	41 NX
Heart muscle	91 NX
Lung	62 NX
Prostate	57 NX
Placenta	52 NX
Skin	21 NX

Glandular cells	44 NX
Prostate	44 NX

Granulocytes	12 NX
Lung	14 NX
Colon	9 NX

Hepatocytes	31 NX
Liver	31 NX

Hofbauer cells	30 NX
Placenta	30 NX

Horizontal cells	51 NX
Eye	51 NX

Intestinal endocrine cells	41 NX
Colon	44 NX
Rectum	37 NX

Ito cells	33 NX
Liver	33 NX

Kupffer cells	70 NX
Liver	70 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	38 NX
Testis	38 NX

Macrophages	36 NX
Kidney	80 NX
Lung	49 NX
Prostate	44 NX
Skin	33 NX
Testis	33 NX
Pancreas	28 NX

Melanocytes	17 NX
Skin	17 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	25 NX
Pancreas	25 NX

Mucus-secreting cells	44 NX
Colon	53 NX
Rectum	45 NX
Small intestine	29 NX

Muller glia cells	50 NX
Eye	50 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	54 NX
Colon	66 NX
Rectum	54 NX
Small intestine	14 NX

Peritubular cells	57 NX
Testis	57 NX

Proximal tubular cells	53 NX
Kidney	53 NX

Rod photoreceptor cells	57 NX
Eye	57 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	25 NX
Heart muscle	99 NX
Prostate	53 NX
Pancreas	25 NX
Skin	19 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	14 NX
Testis	14 NX

Suprabasal keratinocytes	38 NX
Skin	38 NX

Syncytiotrophoblasts	74 NX
Placenta	74 NX

T-cells	21 NX
Lung	27 NX
Prostate	26 NX
Liver	25 NX
Kidney	20 NX
Colon	18 NX
Skin	11 NX

Undifferentiated cells	37 NX
Rectum	43 NX
Colon	38 NX
Small intestine	29 NX

Urothelial cells	43 NX
Prostate	43 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.