Cell type atlas - DDOST - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

DDOST

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDOST
Gene descriptionⁱ Full gene name according to HGNC.	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	60 NX
Lung	60 NX

B-cells	70 NX
Liver	112 NX
Kidney	71 NX
Colon	69 NX

Basal glandular cells	69 NX
Prostate	69 NX

Basal keratinocytes	45 NX
Skin	45 NX

Bipolar cells	16 NX
Eye	16 NX

Cardiomyocytes	19 NX
Heart muscle	19 NX

Cholangiocytes	59 NX
Liver	59 NX

Ciliated cells	75 NX
Lung	75 NX

Club cells	71 NX
Lung	71 NX

Collecting duct cells	33 NX
Kidney	33 NX

Cone photoreceptor cells	28 NX
Eye	28 NX

Cytotrophoblasts	298 NX
Placenta	298 NX

Distal tubular cells	33 NX
Kidney	33 NX

Ductal cells	142 NX
Pancreas	142 NX

Early spermatids	21 NX
Testis	21 NX

Endothelial cells	51 NX
Placenta	119 NX
Pancreas	104 NX
Lung	79 NX
Skin	55 NX
Testis	51 NX
Liver	49 NX
Prostate	44 NX
Eye	43 NX
Heart muscle	20 NX

Enterocytes	45 NX
Small intestine	62 NX
Rectum	57 NX
Colon	36 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	131 NX
Pancreas	131 NX

Extravillous trophoblasts	225 NX
Placenta	225 NX

Fibroblasts	94 NX
Placenta	197 NX
Lung	94 NX
Skin	73 NX
Prostate	61 NX
Heart muscle	23 NX

Glandular cells	65 NX
Prostate	65 NX

Granulocytes	76 NX
Lung	88 NX
Colon	64 NX

Hepatocytes	67 NX
Liver	67 NX

Hofbauer cells	126 NX
Placenta	126 NX

Horizontal cells	16 NX
Eye	16 NX

Intestinal endocrine cells	69 NX
Colon	75 NX
Rectum	63 NX

Ito cells	62 NX
Liver	62 NX

Kupffer cells	67 NX
Liver	67 NX

Late spermatids	12 NX
Testis	12 NX

Leydig cells	69 NX
Testis	69 NX

Macrophages	83 NX
Pancreas	117 NX
Prostate	106 NX
Lung	94 NX
Skin	73 NX
Kidney	63 NX
Testis	63 NX

Melanocytes	81 NX
Skin	81 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	115 NX
Pancreas	115 NX

Mucus-secreting cells	106 NX
Colon	200 NX
Rectum	103 NX
Small intestine	71 NX

Muller glia cells	52 NX
Eye	52 NX

Pancreatic endocrine cells	92 NX
Pancreas	92 NX

Paneth cells	91 NX
Rectum	120 NX
Small intestine	91 NX
Colon	35 NX

Peritubular cells	57 NX
Testis	57 NX

Proximal tubular cells	45 NX
Kidney	45 NX

Rod photoreceptor cells	19 NX
Eye	19 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	42 NX
Pancreas	138 NX
Skin	45 NX
Prostate	41 NX
Heart muscle	20 NX

Spermatocytes	108 NX
Testis	108 NX

Spermatogonia	187 NX
Testis	187 NX

Suprabasal keratinocytes	47 NX
Skin	47 NX

Syncytiotrophoblasts	293 NX
Placenta	293 NX

T-cells	81 NX
Lung	105 NX
Liver	82 NX
Kidney	82 NX
Colon	70 NX
Skin	70 NX
Prostate	61 NX

Undifferentiated cells	128 NX
Colon	133 NX
Rectum	111 NX
Small intestine	107 NX

Urothelial cells	58 NX
Prostate	58 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.