Cell type atlas - C4orf48 - The Human Protein Atlas

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C4orf48

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	C4orf48
Gene descriptionⁱ Full gene name according to HGNC.	Chromosome 4 open reading frame 48
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Paneth cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HEK93, NB-4, PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Paneth cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	3 NX
Lung	3 NX

B-cells	61 NX
Colon	73 NX
Liver	54 NX
Kidney	49 NX

Basal glandular cells	5 NX
Prostate	5 NX

Basal keratinocytes	20 NX
Skin	20 NX

Bipolar cells	15 NX
Eye	15 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	7 NX
Lung	7 NX

Club cells	3 NX
Lung	3 NX

Collecting duct cells	190 NX
Kidney	190 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	8 NX
Placenta	8 NX

Distal tubular cells	60 NX
Kidney	60 NX

Ductal cells	304 NX
Pancreas	304 NX

Early spermatids	77 NX
Testis	77 NX

Endothelial cells	29 NX
Pancreas	158 NX
Liver	103 NX
Placenta	46 NX
Eye	35 NX
Skin	33 NX
Heart muscle	21 NX
Prostate	20 NX
Testis	13 NX
Lung	0 NX

Enterocytes	186 NX
Colon	500 NX
Small intestine	161 NX
Rectum	123 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	194 NX
Pancreas	194 NX

Extravillous trophoblasts	112 NX
Placenta	112 NX

Fibroblasts	26 NX
Placenta	93 NX
Heart muscle	49 NX
Skin	22 NX
Prostate	17 NX
Lung	15 NX

Glandular cells	13 NX
Prostate	13 NX

Granulocytes	109 NX
Colon	193 NX
Lung	26 NX

Hepatocytes	9 NX
Liver	9 NX

Hofbauer cells	199 NX
Placenta	199 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	226 NX
Colon	262 NX
Rectum	190 NX

Ito cells	114 NX
Liver	114 NX

Kupffer cells	261 NX
Liver	261 NX

Late spermatids	248 NX
Testis	248 NX

Leydig cells	18 NX
Testis	18 NX

Macrophages	118 NX
Kidney	303 NX
Pancreas	250 NX
Testis	127 NX
Skin	122 NX
Prostate	109 NX
Lung	9 NX

Melanocytes	310 NX
Skin	310 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	65 NX
Pancreas	65 NX

Mucus-secreting cells	98 NX
Colon	222 NX
Small intestine	127 NX
Rectum	60 NX

Muller glia cells	44 NX
Eye	44 NX

Pancreatic endocrine cells	199 NX
Pancreas	199 NX

Paneth cells	379 NX
Colon	780 NX
Small intestine	379 NX
Rectum	140 NX

Peritubular cells	27 NX
Testis	27 NX

Proximal tubular cells	7 NX
Kidney	7 NX

Rod photoreceptor cells	12 NX
Eye	12 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	13 NX
Pancreas	235 NX
Heart muscle	13 NX
Prostate	13 NX
Skin	12 NX

Spermatocytes	62 NX
Testis	62 NX

Spermatogonia	167 NX
Testis	167 NX

Suprabasal keratinocytes	9 NX
Skin	9 NX

Syncytiotrophoblasts	11 NX
Placenta	11 NX

T-cells	64 NX
Colon	108 NX
Skin	104 NX
Prostate	65 NX
Kidney	64 NX
Liver	23 NX
Lung	6 NX

Undifferentiated cells	74 NX
Colon	163 NX
Small intestine	86 NX
Rectum	36 NX

Urothelial cells	9 NX
Prostate	9 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.