Cell type atlas - PPIL3 - The Human Protein Atlas

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PPIL3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PPIL3
Gene descriptionⁱ Full gene name according to HGNC.	Peptidylprolyl isomerase like 3
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	12 NX
Lung	12 NX

B-cells	24 NX
Colon	33 NX
Kidney	31 NX
Liver	16 NX

Basal glandular cells	39 NX
Prostate	39 NX

Basal keratinocytes	28 NX
Skin	28 NX

Bipolar cells	13 NX
Eye	12 NX

Cardiomyocytes	18 NX
Heart muscle	18 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	21 NX
Lung	21 NX

Club cells	11 NX
Lung	11 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	45 NX
Placenta	45 NX

Distal tubular cells	48 NX
Kidney	48 NX

Ductal cells	20 NX
Pancreas	20 NX

Early spermatids	15 NX
Testis	15 NX

Endothelial cells	16 NX
Skin	31 NX
Placenta	31 NX
Pancreas	22 NX
Testis	20 NX
Liver	16 NX
Eye	14 NX
Heart muscle	11 NX
Prostate	10 NX
Lung	6 NX

Enterocytes	13 NX
Small intestine	21 NX
Rectum	10 NX
Colon	6 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	14 NX
Pancreas	14 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	34 NX
Placenta	40 NX
Skin	36 NX
Prostate	12 NX
Heart muscle	8 NX
Lung	5 NX

Glandular cells	18 NX
Prostate	18 NX

Granulocytes	25 NX
Colon	28 NX
Lung	23 NX

Hepatocytes	16 NX
Liver	16 NX

Hofbauer cells	42 NX
Placenta	42 NX

Horizontal cells	3 NX
Eye	3 NX

Intestinal endocrine cells	9 NX
Colon	14 NX
Rectum	5 NX

Ito cells	16 NX
Liver	16 NX

Kupffer cells	41 NX
Liver	41 NX

Late spermatids	3 NX
Testis	3 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	46 NX
Skin	70 NX
Prostate	58 NX
Testis	52 NX
Lung	29 NX
Kidney	26 NX
Pancreas	21 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	25 NX
Rectum	30 NX
Small intestine	22 NX
Colon	13 NX

Muller glia cells	17 NX
Eye	17 NX

Pancreatic endocrine cells	19 NX
Pancreas	19 NX

Paneth cells	25 NX
Rectum	25 NX
Small intestine	25 NX
Colon	0 NX

Peritubular cells	27 NX
Testis	27 NX

Proximal tubular cells	45 NX
Kidney	45 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	29 NX
Heart muscle	31 NX
Pancreas	29 NX
Skin	27 NX
Prostate	26 NX

Spermatocytes	37 NX
Testis	37 NX

Spermatogonia	22 NX
Testis	22 NX

Suprabasal keratinocytes	41 NX
Skin	41 NX

Syncytiotrophoblasts	26 NX
Placenta	26 NX

T-cells	33 NX
Skin	49 NX
Liver	37 NX
Kidney	33 NX
Colon	32 NX
Prostate	22 NX
Lung	16 NX

Undifferentiated cells	29 NX
Small intestine	39 NX
Rectum	28 NX
Colon	14 NX

Urothelial cells	24 NX
Prostate	24 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.