Cell type atlas - TMA7 - The Human Protein Atlas

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TMA7

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TMA7
Gene descriptionⁱ Full gene name according to HGNC.	Translation machinery associated 7 homolog
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	223 NX
Lung	223 NX

Alveolar cells type 2	369 NX
Lung	369 NX

B-cells	511 NX
Liver	733 NX
Kidney	655 NX
Colon	367 NX

Basal glandular cells	446 NX
Prostate	446 NX

Basal keratinocytes	636 NX
Skin	636 NX

Bipolar cells	196 NX
Eye	196 NX

Cardiomyocytes	595 NX
Heart muscle	595 NX

Cholangiocytes	571 NX
Liver	571 NX

Ciliated cells	348 NX
Lung	348 NX

Club cells	349 NX
Lung	349 NX

Collecting duct cells	855 NX
Kidney	855 NX

Cone photoreceptor cells	100 NX
Eye	100 NX

Cytotrophoblasts	707 NX
Placenta	706 NX

Distal tubular cells	1456 NX
Kidney	1456 NX

Ductal cells	502 NX
Pancreas	502 NX

Early spermatids	547 NX
Testis	547 NX

Endothelial cells	428 NX
Liver	769 NX
Placenta	679 NX
Skin	573 NX
Pancreas	505 NX
Testis	428 NX
Heart muscle	364 NX
Prostate	335 NX
Lung	286 NX
Eye	206 NX

Enterocytes	900 NX
Small intestine	986 NX
Rectum	886 NX
Colon	815 NX

Erythroid cells	444 NX
Liver	444 NX

Exocrine glandular cells	893 NX
Pancreas	893 NX

Extravillous trophoblasts	694 NX
Placenta	694 NX

Fibroblasts	536 NX
Skin	619 NX
Placenta	485 NX
Heart muscle	443 NX
Lung	233 NX
Prostate	217 NX

Glandular cells	516 NX
Prostate	516 NX

Granulocytes	437 NX
Lung	526 NX
Colon	349 NX

Hepatocytes	866 NX
Liver	866 NX

Hofbauer cells	741 NX
Placenta	741 NX

Horizontal cells	113 NX
Eye	113 NX

Intestinal endocrine cells	611 NX
Rectum	704 NX
Colon	517 NX

Ito cells	536 NX
Liver	536 NX

Kupffer cells	637 NX
Liver	637 NX

Late spermatids	794 NX
Testis	794 NX

Leydig cells	599 NX
Testis	599 NX

Macrophages	617 NX
Kidney	1025 NX
Skin	765 NX
Pancreas	716 NX
Testis	539 NX
Prostate	380 NX
Lung	351 NX

Melanocytes	737 NX
Skin	737 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	776 NX
Pancreas	776 NX

Mucus-secreting cells	895 NX
Rectum	919 NX
Colon	899 NX
Small intestine	770 NX

Muller glia cells	245 NX
Eye	245 NX

Pancreatic endocrine cells	728 NX
Pancreas	728 NX

Paneth cells	822 NX
Colon	1068 NX
Rectum	822 NX
Small intestine	758 NX

Peritubular cells	437 NX
Testis	437 NX

Proximal tubular cells	886 NX
Kidney	886 NX

Rod photoreceptor cells	223 NX
Eye	223 NX

Sertoli cells	349 NX
Testis	349 NX

Smooth muscle cells	415 NX
Pancreas	611 NX
Skin	419 NX
Heart muscle	345 NX
Prostate	216 NX

Spermatocytes	508 NX
Testis	508 NX

Spermatogonia	744 NX
Testis	744 NX

Suprabasal keratinocytes	785 NX
Skin	785 NX

Syncytiotrophoblasts	368 NX
Placenta	368 NX

T-cells	657 NX
Kidney	1060 NX
Skin	937 NX
Liver	699 NX
Lung	595 NX
Colon	475 NX
Prostate	327 NX

Undifferentiated cells	795 NX
Rectum	928 NX
Small intestine	792 NX
Colon	655 NX

Urothelial cells	485 NX
Prostate	485 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.