Cell type atlas - ZNF580 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ZNF580

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ZNF580
Gene descriptionⁱ Full gene name according to HGNC.	Zinc finger protein 580
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Transcription factors
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enriched (HEK93)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	9 NX
Lung	9 NX

B-cells	36 NX
Kidney	40 NX
Liver	35 NX
Colon	31 NX

Basal glandular cells	32 NX
Prostate	32 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	31 NX
Eye	31 NX

Cardiomyocytes	9 NX
Heart muscle	9 NX

Cholangiocytes	33 NX
Liver	33 NX

Ciliated cells	1 NX
Lung	1 NX

Club cells	6 NX
Lung	6 NX

Collecting duct cells	54 NX
Kidney	54 NX

Cone photoreceptor cells	4 NX
Eye	4 NX

Cytotrophoblasts	24 NX
Placenta	24 NX

Distal tubular cells	65 NX
Kidney	65 NX

Ductal cells	36 NX
Pancreas	36 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	32 NX
Pancreas	57 NX
Testis	45 NX
Prostate	42 NX
Eye	37 NX
Placenta	35 NX
Liver	32 NX
Skin	31 NX
Heart muscle	8 NX
Lung	0 NX

Enterocytes	26 NX
Small intestine	41 NX
Rectum	21 NX
Colon	21 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	49 NX
Pancreas	49 NX

Extravillous trophoblasts	17 NX
Placenta	17 NX

Fibroblasts	32 NX
Skin	34 NX
Prostate	34 NX
Placenta	28 NX
Heart muscle	12 NX
Lung	3 NX

Glandular cells	35 NX
Prostate	35 NX

Granulocytes	20 NX
Colon	37 NX
Lung	2 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	22 NX
Placenta	22 NX

Horizontal cells	19 NX
Eye	19 NX

Intestinal endocrine cells	65 NX
Colon	85 NX
Rectum	45 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	25 NX
Liver	25 NX

Late spermatids	4 NX
Testis	4 NX

Leydig cells	55 NX
Testis	55 NX

Macrophages	28 NX
Pancreas	42 NX
Kidney	41 NX
Testis	36 NX
Skin	28 NX
Prostate	26 NX
Lung	2 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	46 NX
Pancreas	46 NX

Mucus-secreting cells	24 NX
Small intestine	30 NX
Rectum	23 NX
Colon	16 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	38 NX
Pancreas	38 NX

Paneth cells	28 NX
Rectum	36 NX
Small intestine	28 NX
Colon	20 NX

Peritubular cells	66 NX
Testis	66 NX

Proximal tubular cells	56 NX
Kidney	56 NX

Rod photoreceptor cells	17 NX
Eye	17 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	37 NX
Prostate	65 NX
Pancreas	57 NX
Skin	36 NX
Heart muscle	10 NX

Spermatocytes	8 NX
Testis	8 NX

Spermatogonia	12 NX
Testis	12 NX

Suprabasal keratinocytes	15 NX
Skin	15 NX

Syncytiotrophoblasts	16 NX
Placenta	16 NX

T-cells	20 NX
Prostate	35 NX
Skin	22 NX
Colon	21 NX
Liver	19 NX
Kidney	17 NX
Lung	7 NX

Undifferentiated cells	27 NX
Small intestine	33 NX
Rectum	27 NX
Colon	21 NX

Urothelial cells	28 NX
Prostate	28 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.