Cell type atlas - MT1M - The Human Protein Atlas

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MT1M

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MT1M
Gene descriptionⁱ Full gene name according to HGNC.	Metallothionein 1M
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Hepatocytes, Paneth cells, Mucus-secreting cells, Enterocytes, Undifferentiated cells, Smooth muscle cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in single
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enriched (RPTEC TERT1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Hepatocytes, Paneth cells, Mucus-secreting cells, Enterocytes, Undifferentiated cells, Smooth muscle cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	7 NX
Lung	7 NX

B-cells	12 NX
Liver	23 NX
Kidney	9 NX
Colon	0 NX

Basal glandular cells	16 NX
Prostate	16 NX

Basal keratinocytes	25 NX
Skin	25 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	69 NX
Liver	69 NX

Ciliated cells	8 NX
Lung	8 NX

Club cells	10 NX
Lung	10 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	0 NX
Placenta	0 NX

Distal tubular cells	32 NX
Kidney	32 NX

Ductal cells	58 NX
Pancreas	58 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	32 NX
Lung	184 NX
Testis	64 NX
Heart muscle	50 NX
Skin	38 NX
Prostate	34 NX
Placenta	32 NX
Liver	27 NX
Eye	0 NX
Pancreas	0 NX

Enterocytes	366 NX
Rectum	1389 NX
Small intestine	709 NX
Colon	199 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	101 NX
Pancreas	101 NX

Extravillous trophoblasts	51 NX
Placenta	51 NX

Fibroblasts	76 NX
Skin	258 NX
Lung	252 NX
Prostate	76 NX
Heart muscle	51 NX
Placenta	3 NX

Glandular cells	118 NX
Prostate	118 NX

Granulocytes	16 NX
Colon	28 NX
Lung	5 NX

Hepatocytes	1086 NX
Liver	1086 NX

Hofbauer cells	2 NX
Placenta	2 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	32 NX
Rectum	56 NX
Colon	7 NX

Ito cells	60 NX
Liver	60 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	44 NX
Testis	44 NX

Macrophages	29 NX
Pancreas	157 NX
Prostate	117 NX
Skin	33 NX
Kidney	29 NX
Testis	29 NX
Lung	15 NX

Melanocytes	84 NX
Skin	84 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	42 NX
Pancreas	42 NX

Mucus-secreting cells	420 NX
Rectum	502 NX
Small intestine	382 NX
Colon	211 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	71 NX
Pancreas	71 NX

Paneth cells	860 NX
Small intestine	1704 NX
Rectum	860 NX
Colon	734 NX

Peritubular cells	11 NX
Testis	11 NX

Proximal tubular cells	77 NX
Kidney	77 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	78 NX
Testis	78 NX

Smooth muscle cells	335 NX
Prostate	929 NX
Skin	486 NX
Heart muscle	181 NX
Pancreas	34 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	1 NX
Placenta	1 NX

T-cells	10 NX
Skin	32 NX
Liver	18 NX
Kidney	8 NX
Colon	7 NX
Lung	6 NX
Prostate	4 NX

Undifferentiated cells	353 NX
Small intestine	627 NX
Rectum	394 NX
Colon	73 NX

Urothelial cells	5 NX
Prostate	5 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.