Cell type atlas - AKT1S1 - The Human Protein Atlas

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AKT1S1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AKT1S1
Gene descriptionⁱ Full gene name according to HGNC.	AKT1 substrate 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	8

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	4 NX
Lung	4 NX

B-cells	10 NX
Colon	22 NX
Liver	8 NX
Kidney	5 NX

Basal glandular cells	23 NX
Prostate	23 NX

Basal keratinocytes	13 NX
Skin	13 NX

Bipolar cells	11 NX
Eye	11 NX

Cardiomyocytes	5 NX
Heart muscle	5 NX

Cholangiocytes	31 NX
Liver	31 NX

Ciliated cells	0 NX
Lung	0 NX

Club cells	2 NX
Lung	2 NX

Collecting duct cells	10 NX
Kidney	10 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	54 NX
Placenta	54 NX

Distal tubular cells	38 NX
Kidney	38 NX

Ductal cells	29 NX
Pancreas	29 NX

Early spermatids	23 NX
Testis	23 NX

Endothelial cells	16 NX
Placenta	37 NX
Prostate	33 NX
Pancreas	32 NX
Testis	21 NX
Skin	18 NX
Liver	16 NX
Eye	8 NX
Heart muscle	5 NX
Lung	0 NX

Enterocytes	47 NX
Colon	60 NX
Small intestine	44 NX
Rectum	34 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	35 NX
Pancreas	35 NX

Extravillous trophoblasts	41 NX
Placenta	41 NX

Fibroblasts	28 NX
Prostate	33 NX
Placenta	29 NX
Skin	22 NX
Heart muscle	10 NX
Lung	2 NX

Glandular cells	37 NX
Prostate	37 NX

Granulocytes	5 NX
Colon	9 NX
Lung	0 NX

Hepatocytes	33 NX
Liver	33 NX

Hofbauer cells	27 NX
Placenta	27 NX

Horizontal cells	10 NX
Eye	10 NX

Intestinal endocrine cells	29 NX
Rectum	31 NX
Colon	27 NX

Ito cells	12 NX
Liver	12 NX

Kupffer cells	19 NX
Liver	19 NX

Late spermatids	9 NX
Testis	9 NX

Leydig cells	22 NX
Testis	22 NX

Macrophages	18 NX
Kidney	25 NX
Pancreas	19 NX
Skin	19 NX
Prostate	19 NX
Testis	5 NX
Lung	4 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	33 NX
Colon	40 NX
Small intestine	35 NX
Rectum	28 NX

Muller glia cells	29 NX
Eye	29 NX

Pancreatic endocrine cells	28 NX
Pancreas	28 NX

Paneth cells	32 NX
Small intestine	32 NX
Rectum	32 NX
Colon	26 NX

Peritubular cells	27 NX
Testis	27 NX

Proximal tubular cells	41 NX
Kidney	41 NX

Rod photoreceptor cells	11 NX
Eye	11 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	30 NX
Pancreas	58 NX
Prostate	31 NX
Skin	28 NX
Heart muscle	5 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	13 NX
Testis	13 NX

Suprabasal keratinocytes	18 NX
Skin	18 NX

Syncytiotrophoblasts	109 NX
Placenta	109 NX

T-cells	10 NX
Colon	20 NX
Liver	13 NX
Kidney	9 NX
Skin	8 NX
Lung	2 NX
Prostate	0 NX

Undifferentiated cells	32 NX
Colon	33 NX
Small intestine	32 NX
Rectum	30 NX

Urothelial cells	24 NX
Prostate	24 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.