Cell type atlas - HLA-F - The Human Protein Atlas

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HLA-F

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	HLA-F
Gene descriptionⁱ Full gene name according to HGNC.	Major histocompatibility complex, class I, F
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes, T-cells, Enterocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A-431, GAMG, HEK93, HEL, HHSteC, JURKAT, U-266/70, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in some
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes, T-cells, Enterocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	77 NX
Lung	77 NX

B-cells	91 NX
Colon	176 NX
Kidney	98 NX
Liver	63 NX

Basal glandular cells	28 NX
Prostate	28 NX

Basal keratinocytes	36 NX
Skin	36 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	7 NX
Kidney	7 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	0 NX
Placenta	0 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	53 NX
Pancreas	53 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	104 NX
Heart muscle	150 NX
Lung	140 NX
Testis	127 NX
Prostate	124 NX
Liver	110 NX
Pancreas	97 NX
Eye	88 NX
Skin	85 NX
Placenta	34 NX

Enterocytes	190 NX
Small intestine	288 NX
Rectum	181 NX
Colon	92 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	79 NX
Pancreas	79 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	20 NX
Lung	58 NX
Prostate	40 NX
Skin	20 NX
Heart muscle	13 NX
Placenta	12 NX

Glandular cells	29 NX
Prostate	29 NX

Granulocytes	49 NX
Lung	51 NX
Colon	46 NX

Hepatocytes	25 NX
Liver	25 NX

Hofbauer cells	58 NX
Placenta	58 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	22 NX
Rectum	23 NX
Colon	20 NX

Ito cells	65 NX
Liver	65 NX

Kupffer cells	69 NX
Liver	69 NX

Late spermatids	0 NX
Testis	0 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	77 NX
Lung	173 NX
Kidney	94 NX
Pancreas	87 NX
Testis	67 NX
Prostate	60 NX
Skin	47 NX

Melanocytes	27 NX
Skin	27 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	255 NX
Pancreas	255 NX

Mucus-secreting cells	112 NX
Colon	149 NX
Small intestine	112 NX
Rectum	44 NX

Muller glia cells	5 NX
Eye	5 NX

Pancreatic endocrine cells	62 NX
Pancreas	62 NX

Paneth cells	84 NX
Colon	176 NX
Small intestine	84 NX
Rectum	68 NX

Peritubular cells	20 NX
Testis	20 NX

Proximal tubular cells	5 NX
Kidney	5 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	45 NX
Testis	45 NX

Smooth muscle cells	38 NX
Skin	44 NX
Heart muscle	40 NX
Prostate	38 NX
Pancreas	13 NX

Spermatocytes	10 NX
Testis	10 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	33 NX
Skin	33 NX

Syncytiotrophoblasts	0 NX
Placenta	0 NX

T-cells	237 NX
Lung	345 NX
Liver	264 NX
Kidney	233 NX
Colon	158 NX
Skin	88 NX
Prostate	52 NX

Undifferentiated cells	52 NX
Small intestine	74 NX
Rectum	52 NX
Colon	49 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.