Cell type atlas - ABCF1 - The Human Protein Atlas

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ABCF1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	ABCF1
Gene descriptionⁱ Full gene name according to HGNC.	ATP binding cassette subfamily F member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	48 NX
Lung	48 NX

Alveolar cells type 2	85 NX
Lung	85 NX

B-cells	57 NX
Colon	78 NX
Liver	61 NX
Kidney	36 NX

Basal glandular cells	80 NX
Prostate	80 NX

Basal keratinocytes	77 NX
Skin	77 NX

Bipolar cells	42 NX
Eye	42 NX

Cardiomyocytes	76 NX
Heart muscle	76 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	50 NX
Lung	50 NX

Club cells	79 NX
Lung	79 NX

Collecting duct cells	56 NX
Kidney	56 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	84 NX
Placenta	84 NX

Distal tubular cells	51 NX
Kidney	51 NX

Ductal cells	84 NX
Pancreas	84 NX

Early spermatids	80 NX
Testis	80 NX

Endothelial cells	47 NX
Pancreas	133 NX
Prostate	70 NX
Lung	67 NX
Placenta	47 NX
Eye	46 NX
Heart muscle	45 NX
Skin	39 NX
Testis	38 NX
Liver	38 NX

Enterocytes	75 NX
Colon	92 NX
Small intestine	61 NX
Rectum	32 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	76 NX
Pancreas	76 NX

Extravillous trophoblasts	116 NX
Placenta	116 NX

Fibroblasts	50 NX
Lung	98 NX
Prostate	71 NX
Heart muscle	55 NX
Placenta	51 NX
Skin	36 NX

Glandular cells	63 NX
Prostate	63 NX

Granulocytes	85 NX
Colon	101 NX
Lung	70 NX

Hepatocytes	115 NX
Liver	115 NX

Hofbauer cells	44 NX
Placenta	44 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	49 NX
Colon	65 NX
Rectum	33 NX

Ito cells	34 NX
Liver	34 NX

Kupffer cells	39 NX
Liver	39 NX

Late spermatids	123 NX
Testis	123 NX

Leydig cells	36 NX
Testis	36 NX

Macrophages	47 NX
Lung	84 NX
Testis	57 NX
Pancreas	52 NX
Kidney	42 NX
Prostate	37 NX
Skin	37 NX

Melanocytes	34 NX
Skin	34 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	68 NX
Pancreas	68 NX

Mucus-secreting cells	41 NX
Colon	129 NX
Small intestine	51 NX
Rectum	33 NX

Muller glia cells	42 NX
Eye	42 NX

Pancreatic endocrine cells	85 NX
Pancreas	85 NX

Paneth cells	39 NX
Colon	121 NX
Small intestine	39 NX
Rectum	38 NX

Peritubular cells	49 NX
Testis	49 NX

Proximal tubular cells	59 NX
Kidney	59 NX

Rod photoreceptor cells	108 NX
Eye	108 NX

Sertoli cells	71 NX
Testis	71 NX

Smooth muscle cells	55 NX
Pancreas	70 NX
Heart muscle	65 NX
Prostate	55 NX
Skin	39 NX

Spermatocytes	135 NX
Testis	135 NX

Spermatogonia	94 NX
Testis	94 NX

Suprabasal keratinocytes	74 NX
Skin	74 NX

Syncytiotrophoblasts	139 NX
Placenta	139 NX

T-cells	55 NX
Colon	115 NX
Lung	109 NX
Prostate	57 NX
Kidney	55 NX
Liver	41 NX
Skin	25 NX

Undifferentiated cells	46 NX
Colon	110 NX
Small intestine	44 NX
Rectum	40 NX

Urothelial cells	74 NX
Prostate	74 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.