Cell type atlas - RNF5 - The Human Protein Atlas

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RNF5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNF5
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger protein 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	31 NX
Lung	31 NX

B-cells	63 NX
Kidney	76 NX
Colon	51 NX
Liver	41 NX

Basal glandular cells	54 NX
Prostate	54 NX

Basal keratinocytes	85 NX
Skin	85 NX

Bipolar cells	22 NX
Eye	22 NX

Cardiomyocytes	55 NX
Heart muscle	55 NX

Cholangiocytes	82 NX
Liver	82 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	43 NX
Lung	43 NX

Collecting duct cells	87 NX
Kidney	87 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	67 NX
Placenta	67 NX

Distal tubular cells	240 NX
Kidney	240 NX

Ductal cells	92 NX
Pancreas	92 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	47 NX
Skin	100 NX
Placenta	64 NX
Testis	61 NX
Liver	59 NX
Pancreas	47 NX
Prostate	46 NX
Eye	28 NX
Heart muscle	25 NX
Lung	23 NX

Enterocytes	172 NX
Small intestine	228 NX
Rectum	149 NX
Colon	113 NX

Erythroid cells	70 NX
Liver	70 NX

Exocrine glandular cells	79 NX
Pancreas	79 NX

Extravillous trophoblasts	86 NX
Placenta	86 NX

Fibroblasts	61 NX
Skin	74 NX
Placenta	58 NX
Prostate	47 NX
Heart muscle	35 NX
Lung	30 NX

Glandular cells	54 NX
Prostate	54 NX

Granulocytes	54 NX
Lung	63 NX
Colon	46 NX

Hepatocytes	113 NX
Liver	113 NX

Hofbauer cells	61 NX
Placenta	61 NX

Horizontal cells	32 NX
Eye	32 NX

Intestinal endocrine cells	70 NX
Rectum	80 NX
Colon	61 NX

Ito cells	42 NX
Liver	42 NX

Kupffer cells	43 NX
Liver	43 NX

Late spermatids	15 NX
Testis	15 NX

Leydig cells	55 NX
Testis	55 NX

Macrophages	54 NX
Skin	123 NX
Pancreas	75 NX
Kidney	58 NX
Testis	49 NX
Prostate	43 NX
Lung	35 NX

Melanocytes	81 NX
Skin	81 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	88 NX
Pancreas	88 NX

Mucus-secreting cells	77 NX
Small intestine	92 NX
Rectum	77 NX
Colon	60 NX

Muller glia cells	60 NX
Eye	60 NX

Pancreatic endocrine cells	70 NX
Pancreas	70 NX

Paneth cells	153 NX
Small intestine	211 NX
Colon	153 NX
Rectum	108 NX

Peritubular cells	68 NX
Testis	68 NX

Proximal tubular cells	293 NX
Kidney	293 NX

Rod photoreceptor cells	20 NX
Eye	20 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	69 NX
Skin	118 NX
Prostate	69 NX
Pancreas	51 NX
Heart muscle	39 NX

Spermatocytes	58 NX
Testis	58 NX

Spermatogonia	36 NX
Testis	36 NX

Suprabasal keratinocytes	74 NX
Skin	74 NX

Syncytiotrophoblasts	70 NX
Placenta	70 NX

T-cells	52 NX
Skin	106 NX
Kidney	75 NX
Colon	56 NX
Liver	51 NX
Lung	37 NX
Prostate	35 NX

Undifferentiated cells	93 NX
Small intestine	98 NX
Rectum	93 NX
Colon	86 NX

Urothelial cells	42 NX
Prostate	42 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.