Cell type atlas - PSMB8 - The Human Protein Atlas

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PSMB8

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSMB8
Gene descriptionⁱ Full gene name according to HGNC.	Proteasome subunit beta 8
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (Daudi)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	59 NX
Lung	59 NX

B-cells	174 NX
Kidney	223 NX
Liver	152 NX
Colon	128 NX

Basal glandular cells	61 NX
Prostate	61 NX

Basal keratinocytes	75 NX
Skin	75 NX

Bipolar cells	2 NX
Eye	2 NX

Cardiomyocytes	6 NX
Heart muscle	6 NX

Cholangiocytes	79 NX
Liver	79 NX

Ciliated cells	63 NX
Lung	63 NX

Club cells	46 NX
Lung	46 NX

Collecting duct cells	59 NX
Kidney	59 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	2 NX
Placenta	2 NX

Distal tubular cells	73 NX
Kidney	73 NX

Ductal cells	174 NX
Pancreas	174 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	122 NX
Testis	235 NX
Prostate	204 NX
Heart muscle	156 NX
Skin	145 NX
Pancreas	122 NX
Placenta	109 NX
Liver	97 NX
Eye	87 NX
Lung	82 NX

Enterocytes	242 NX
Small intestine	259 NX
Colon	251 NX
Rectum	157 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	218 NX
Pancreas	218 NX

Extravillous trophoblasts	10 NX
Placenta	10 NX

Fibroblasts	57 NX
Placenta	76 NX
Skin	63 NX
Lung	57 NX
Prostate	53 NX
Heart muscle	19 NX

Glandular cells	72 NX
Prostate	72 NX

Granulocytes	50 NX
Colon	55 NX
Lung	44 NX

Hepatocytes	67 NX
Liver	67 NX

Hofbauer cells	157 NX
Placenta	157 NX

Horizontal cells	6 NX
Eye	6 NX

Intestinal endocrine cells	63 NX
Colon	75 NX
Rectum	52 NX

Ito cells	92 NX
Liver	92 NX

Kupffer cells	136 NX
Liver	136 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	36 NX
Testis	36 NX

Macrophages	112 NX
Kidney	231 NX
Pancreas	180 NX
Lung	118 NX
Testis	100 NX
Skin	96 NX
Prostate	64 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	193 NX
Pancreas	193 NX

Mucus-secreting cells	164 NX
Colon	315 NX
Small intestine	207 NX
Rectum	130 NX

Muller glia cells	33 NX
Eye	33 NX

Pancreatic endocrine cells	164 NX
Pancreas	164 NX

Paneth cells	248 NX
Small intestine	347 NX
Colon	248 NX
Rectum	189 NX

Peritubular cells	29 NX
Testis	29 NX

Proximal tubular cells	52 NX
Kidney	52 NX

Rod photoreceptor cells	3 NX
Eye	3 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	46 NX
Skin	70 NX
Pancreas	60 NX
Prostate	43 NX
Heart muscle	28 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	70 NX
Skin	70 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	194 NX
Kidney	239 NX
Liver	213 NX
Colon	179 NX
Lung	168 NX
Skin	167 NX
Prostate	74 NX

Undifferentiated cells	184 NX
Small intestine	224 NX
Colon	213 NX
Rectum	115 NX

Urothelial cells	98 NX
Prostate	98 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.