Cell type atlas - TGM2 - The Human Protein Atlas

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TGM2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TGM2
Gene descriptionⁱ Full gene name according to HGNC.	Transglutaminase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Ito cells, Syncytiotrophoblasts, Cytotrophoblasts, Pancreatic endocrine cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (intermediate monocyte, myeloid DC, memory B-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in some
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Group enriched (CAPAN-2, EFO-21, hTERT-RPE1, HUVEC TERT2, TIME)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Ito cells, Syncytiotrophoblasts, Cytotrophoblasts, Pancreatic endocrine cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	9 NX
Lung	9 NX

Alveolar cells type 2	29 NX
Lung	29 NX

B-cells	15 NX
Liver	22 NX
Colon	16 NX
Kidney	5 NX

Basal glandular cells	10 NX
Prostate	10 NX

Basal keratinocytes	1 NX
Skin	1 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	157 NX
Heart muscle	157 NX

Cholangiocytes	48 NX
Liver	48 NX

Ciliated cells	16 NX
Lung	16 NX

Club cells	27 NX
Lung	27 NX

Collecting duct cells	14 NX
Kidney	14 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	276 NX
Placenta	276 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	184 NX
Pancreas	184 NX

Early spermatids	2 NX
Testis	2 NX

Endothelial cells	167 NX
Liver	838 NX
Heart muscle	299 NX
Prostate	205 NX
Lung	198 NX
Placenta	187 NX
Eye	167 NX
Testis	44 NX
Pancreas	29 NX
Skin	6 NX

Enterocytes	4 NX
Small intestine	54 NX
Colon	2 NX
Rectum	0 NX

Erythroid cells	94 NX
Liver	94 NX

Exocrine glandular cells	125 NX
Pancreas	125 NX

Extravillous trophoblasts	22 NX
Placenta	22 NX

Fibroblasts	46 NX
Heart muscle	106 NX
Prostate	86 NX
Placenta	80 NX
Lung	31 NX
Skin	0 NX

Glandular cells	45 NX
Prostate	45 NX

Granulocytes	2 NX
Lung	5 NX
Colon	0 NX

Hepatocytes	137 NX
Liver	137 NX

Hofbauer cells	49 NX
Placenta	49 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	0 NX
Colon	0 NX
Rectum	0 NX

Ito cells	327 NX
Liver	327 NX

Kupffer cells	23 NX
Liver	23 NX

Late spermatids	4 NX
Testis	3 NX

Leydig cells	1 NX
Testis	1 NX

Macrophages	11 NX
Pancreas	250 NX
Lung	58 NX
Kidney	22 NX
Prostate	13 NX
Skin	2 NX
Testis	1 NX

Melanocytes	0 NX
Skin	0 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	11 NX
Pancreas	11 NX

Mucus-secreting cells	0 NX
Small intestine	6 NX
Rectum	0 NX
Colon	0 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	240 NX
Pancreas	240 NX

Paneth cells	0 NX
Colon	3 NX
Rectum	0 NX
Small intestine	0 NX

Peritubular cells	6 NX
Testis	6 NX

Proximal tubular cells	19 NX
Kidney	19 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	66 NX
Prostate	181 NX
Heart muscle	99 NX
Pancreas	66 NX
Skin	2 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	0 NX
Skin	0 NX

Syncytiotrophoblasts	313 NX
Placenta	313 NX

T-cells	1 NX
Lung	6 NX
Liver	4 NX
Skin	2 NX
Kidney	1 NX
Colon	1 NX
Prostate	0 NX

Undifferentiated cells	0 NX
Small intestine	3 NX
Colon	1 NX
Rectum	0 NX

Urothelial cells	12 NX
Prostate	12 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.