Cell type atlas - MT-CO3 - The Human Protein Atlas

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MT-CO3

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MT-CO3
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrially encoded cytochrome c oxidase III
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HeLa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	1775 NX
Lung	1775 NX

Alveolar cells type 2	2344 NX
Lung	2344 NX

B-cells	18269 NX
Liver	20883 NX
Kidney	18214 NX
Colon	1495 NX

Basal glandular cells	8250 NX
Prostate	8250 NX

Basal keratinocytes	7412 NX
Skin	7412 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	76805 NX
Heart muscle	76805 NX

Cholangiocytes	19304 NX
Liver	19304 NX

Ciliated cells	3076 NX
Lung	3076 NX

Club cells	3886 NX
Lung	3886 NX

Collecting duct cells	15697 NX
Kidney	15697 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	0 NX
Placenta	0 NX

Distal tubular cells	3702 NX
Kidney	3702 NX

Ductal cells	4550 NX
Pancreas	4550 NX

Early spermatids	1674 NX
Testis	1674 NX

Endothelial cells	3293 NX
Heart muscle	29595 NX
Testis	9118 NX
Liver	8411 NX
Prostate	3500 NX
Skin	2557 NX
Pancreas	1712 NX
Lung	1701 NX
Placenta	0 NX
Eye	0 NX

Enterocytes	31597 NX
Rectum	42697 NX
Small intestine	37826 NX
Colon	3308 NX

Erythroid cells	21118 NX
Liver	21118 NX

Exocrine glandular cells	5877 NX
Pancreas	5877 NX

Extravillous trophoblasts	0 NX
Placenta	0 NX

Fibroblasts	3003 NX
Heart muscle	15674 NX
Lung	4404 NX
Skin	3274 NX
Prostate	3009 NX
Placenta	0 NX

Glandular cells	5473 NX
Prostate	5473 NX

Granulocytes	1979 NX
Lung	2967 NX
Colon	992 NX

Hepatocytes	30766 NX
Liver	30766 NX

Hofbauer cells	0 NX
Placenta	0 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	6556 NX
Rectum	11485 NX
Colon	1628 NX

Ito cells	11051 NX
Liver	11051 NX

Kupffer cells	17592 NX
Liver	17592 NX

Late spermatids	7670 NX
Testis	7670 NX

Leydig cells	10722 NX
Testis	10722 NX

Macrophages	5677 NX
Testis	11678 NX
Kidney	11082 NX
Prostate	6604 NX
Skin	5582 NX
Pancreas	5077 NX
Lung	3658 NX

Melanocytes	5267 NX
Skin	5267 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	6541 NX
Pancreas	6541 NX

Mucus-secreting cells	23741 NX
Rectum	29613 NX
Small intestine	19475 NX
Colon	3489 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	4985 NX
Pancreas	4985 NX

Paneth cells	16907 NX
Rectum	23917 NX
Small intestine	16907 NX
Colon	4465 NX

Peritubular cells	7341 NX
Testis	7341 NX

Proximal tubular cells	25199 NX
Kidney	25199 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	11946 NX
Testis	11946 NX

Smooth muscle cells	6322 NX
Heart muscle	21287 NX
Skin	6530 NX
Prostate	5973 NX
Pancreas	3092 NX

Spermatocytes	9983 NX
Testis	9983 NX

Spermatogonia	10815 NX
Testis	10815 NX

Suprabasal keratinocytes	7413 NX
Skin	7413 NX

Syncytiotrophoblasts	0 NX
Placenta	0 NX

T-cells	11569 NX
Kidney	16050 NX
Liver	15333 NX
Skin	3944 NX
Prostate	3583 NX
Lung	3411 NX
Colon	1355 NX

Undifferentiated cells	24591 NX
Rectum	32674 NX
Small intestine	20839 NX
Colon	2380 NX

Urothelial cells	11080 NX
Prostate	11080 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.