Cell type atlas - MT-ND1 - The Human Protein Atlas

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MT-ND1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	MT-ND1
Gene descriptionⁱ Full gene name according to HGNC.	Mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enriched (Cardiomyocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (basophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HeLa)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enriched (Cardiomyocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	1257 NX
Lung	1257 NX

Alveolar cells type 2	1139 NX
Lung	1139 NX

B-cells	6703 NX
Liver	10674 NX
Kidney	3752 NX
Colon	1192 NX

Basal glandular cells	2832 NX
Prostate	2832 NX

Basal keratinocytes	2013 NX
Skin	2013 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	72531 NX
Heart muscle	72531 NX

Cholangiocytes	10000 NX
Liver	10000 NX

Ciliated cells	1801 NX
Lung	1801 NX

Club cells	2083 NX
Lung	2083 NX

Collecting duct cells	4374 NX
Kidney	4374 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	0 NX
Placenta	0 NX

Distal tubular cells	875 NX
Kidney	875 NX

Ductal cells	1190 NX
Pancreas	1190 NX

Early spermatids	925 NX
Testis	925 NX

Endothelial cells	1519 NX
Heart muscle	28324 NX
Testis	5687 NX
Liver	4471 NX
Prostate	2425 NX
Skin	1179 NX
Lung	1120 NX
Pancreas	770 NX
Eye	0 NX
Placenta	0 NX

Enterocytes	10707 NX
Rectum	19741 NX
Small intestine	12657 NX
Colon	2771 NX

Erythroid cells	9882 NX
Liver	9882 NX

Exocrine glandular cells	3135 NX
Pancreas	3135 NX

Extravillous trophoblasts	0 NX
Placenta	0 NX

Fibroblasts	1059 NX
Heart muscle	12649 NX
Lung	2590 NX
Prostate	1483 NX
Skin	1141 NX
Placenta	0 NX

Glandular cells	2565 NX
Prostate	2565 NX

Granulocytes	1330 NX
Lung	1944 NX
Colon	716 NX

Hepatocytes	13675 NX
Liver	13675 NX

Hofbauer cells	0 NX
Placenta	0 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	3019 NX
Rectum	4770 NX
Colon	1268 NX

Ito cells	7369 NX
Liver	7369 NX

Kupffer cells	9328 NX
Liver	9328 NX

Late spermatids	4287 NX
Testis	4287 NX

Leydig cells	6527 NX
Testis	6527 NX

Macrophages	2029 NX
Testis	6727 NX
Kidney	2966 NX
Prostate	1926 NX
Skin	1820 NX
Pancreas	1804 NX
Lung	1797 NX

Melanocytes	1421 NX
Skin	1421 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1887 NX
Pancreas	1887 NX

Mucus-secreting cells	12938 NX
Rectum	18000 NX
Small intestine	8103 NX
Colon	2971 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	1718 NX
Pancreas	1718 NX

Paneth cells	6639 NX
Rectum	11824 NX
Small intestine	6639 NX
Colon	3561 NX

Peritubular cells	3334 NX
Testis	3334 NX

Proximal tubular cells	5210 NX
Kidney	5210 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	6306 NX
Testis	6306 NX

Smooth muscle cells	2438 NX
Heart muscle	18482 NX
Prostate	2511 NX
Skin	2315 NX
Pancreas	874 NX

Spermatocytes	5090 NX
Testis	5090 NX

Spermatogonia	4627 NX
Testis	4627 NX

Suprabasal keratinocytes	1812 NX
Skin	1812 NX

Syncytiotrophoblasts	0 NX
Placenta	0 NX

T-cells	3285 NX
Liver	9231 NX
Kidney	3285 NX
Lung	1651 NX
Prostate	1482 NX
Skin	1359 NX
Colon	1050 NX

Undifferentiated cells	11055 NX
Rectum	17592 NX
Small intestine	7933 NX
Colon	1925 NX

Urothelial cells	4223 NX
Prostate	4223 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.