Cell type atlas - CALM1 - The Human Protein Atlas

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CALM1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CALM1
Gene descriptionⁱ Full gene name according to HGNC.	Calmodulin 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	360 NX
Lung	360 NX

Alveolar cells type 2	314 NX
Lung	314 NX

B-cells	329 NX
Colon	360 NX
Liver	357 NX
Kidney	299 NX

Basal glandular cells	485 NX
Prostate	485 NX

Basal keratinocytes	504 NX
Skin	504 NX

Bipolar cells	1353 NX
Eye	1353 NX

Cardiomyocytes	744 NX
Heart muscle	744 NX

Cholangiocytes	341 NX
Liver	341 NX

Ciliated cells	1962 NX
Lung	1962 NX

Club cells	495 NX
Lung	495 NX

Collecting duct cells	379 NX
Kidney	379 NX

Cone photoreceptor cells	116 NX
Eye	116 NX

Cytotrophoblasts	358 NX
Placenta	358 NX

Distal tubular cells	390 NX
Kidney	390 NX

Ductal cells	485 NX
Pancreas	485 NX

Early spermatids	101 NX
Testis	101 NX

Endothelial cells	794 NX
Pancreas	1465 NX
Heart muscle	1269 NX
Eye	923 NX
Placenta	794 NX
Lung	779 NX
Skin	760 NX
Liver	544 NX
Testis	541 NX
Prostate	483 NX

Enterocytes	1033 NX
Small intestine	1293 NX
Rectum	731 NX
Colon	652 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	392 NX
Pancreas	392 NX

Extravillous trophoblasts	774 NX
Placenta	774 NX

Fibroblasts	358 NX
Heart muscle	971 NX
Lung	633 NX
Skin	476 NX
Prostate	265 NX
Placenta	252 NX

Glandular cells	298 NX
Prostate	298 NX

Granulocytes	469 NX
Lung	616 NX
Colon	321 NX

Hepatocytes	298 NX
Liver	298 NX

Hofbauer cells	680 NX
Placenta	680 NX

Horizontal cells	571 NX
Eye	571 NX

Intestinal endocrine cells	576 NX
Colon	588 NX
Rectum	564 NX

Ito cells	585 NX
Liver	585 NX

Kupffer cells	268 NX
Liver	268 NX

Late spermatids	59 NX
Testis	59 NX

Leydig cells	195 NX
Testis	195 NX

Macrophages	733 NX
Lung	1009 NX
Pancreas	786 NX
Skin	732 NX
Prostate	511 NX
Kidney	457 NX
Testis	447 NX

Melanocytes	596 NX
Skin	596 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1204 NX
Pancreas	1204 NX

Mucus-secreting cells	394 NX
Colon	580 NX
Small intestine	417 NX
Rectum	344 NX

Muller glia cells	1077 NX
Eye	1077 NX

Pancreatic endocrine cells	428 NX
Pancreas	428 NX

Paneth cells	540 NX
Colon	714 NX
Small intestine	540 NX
Rectum	409 NX

Peritubular cells	470 NX
Testis	470 NX

Proximal tubular cells	1074 NX
Kidney	1074 NX

Rod photoreceptor cells	291 NX
Eye	291 NX

Sertoli cells	310 NX
Testis	310 NX

Smooth muscle cells	582 NX
Heart muscle	1493 NX
Pancreas	653 NX
Skin	508 NX
Prostate	499 NX

Spermatocytes	94 NX
Testis	94 NX

Spermatogonia	162 NX
Testis	162 NX

Suprabasal keratinocytes	507 NX
Skin	507 NX

Syncytiotrophoblasts	960 NX
Placenta	960 NX

T-cells	582 NX
Lung	1086 NX
Skin	961 NX
Kidney	889 NX
Prostate	732 NX
Colon	548 NX
Liver	515 NX

Undifferentiated cells	530 NX
Small intestine	639 NX
Colon	530 NX
Rectum	503 NX

Urothelial cells	385 NX
Prostate	385 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.