Cell type atlas - TXNRD1 - The Human Protein Atlas

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TXNRD1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TXNRD1
Gene descriptionⁱ Full gene name according to HGNC.	Thioredoxin reductase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	19

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Urothelial cells, Basal glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (fHDF/TERT166)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Urothelial cells, Basal glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	60 NX
Lung	60 NX

Alveolar cells type 2	55 NX
Lung	55 NX

B-cells	28 NX
Colon	37 NX
Liver	22 NX
Kidney	18 NX

Basal glandular cells	272 NX
Prostate	272 NX

Basal keratinocytes	92 NX
Skin	92 NX

Bipolar cells	28 NX
Eye	28 NX

Cardiomyocytes	56 NX
Heart muscle	56 NX

Cholangiocytes	38 NX
Liver	38 NX

Ciliated cells	104 NX
Lung	104 NX

Club cells	97 NX
Lung	97 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	23 NX
Placenta	23 NX

Distal tubular cells	35 NX
Kidney	35 NX

Ductal cells	73 NX
Pancreas	73 NX

Early spermatids	34 NX
Testis	34 NX

Endothelial cells	41 NX
Prostate	882 NX
Liver	243 NX
Pancreas	86 NX
Heart muscle	64 NX
Lung	41 NX
Skin	29 NX
Testis	29 NX
Eye	17 NX
Placenta	11 NX

Enterocytes	44 NX
Colon	67 NX
Rectum	62 NX
Small intestine	23 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	69 NX
Pancreas	69 NX

Extravillous trophoblasts	28 NX
Placenta	28 NX

Fibroblasts	35 NX
Prostate	381 NX
Lung	166 NX
Heart muscle	72 NX
Skin	31 NX
Placenta	31 NX

Glandular cells	217 NX
Prostate	217 NX

Granulocytes	51 NX
Lung	65 NX
Colon	37 NX

Hepatocytes	46 NX
Liver	46 NX

Hofbauer cells	37 NX
Placenta	37 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	20 NX
Rectum	26 NX
Colon	14 NX

Ito cells	50 NX
Liver	50 NX

Kupffer cells	37 NX
Liver	37 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	63 NX
Testis	63 NX

Macrophages	64 NX
Pancreas	155 NX
Prostate	124 NX
Lung	64 NX
Skin	57 NX
Kidney	28 NX
Testis	18 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	56 NX
Pancreas	56 NX

Mucus-secreting cells	18 NX
Rectum	20 NX
Colon	16 NX
Small intestine	12 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	183 NX
Pancreas	183 NX

Paneth cells	20 NX
Colon	83 NX
Rectum	20 NX
Small intestine	4 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	29 NX
Kidney	29 NX

Rod photoreceptor cells	20 NX
Eye	20 NX

Sertoli cells	0 NX
Testis	0 NX

Smooth muscle cells	59 NX
Prostate	152 NX
Pancreas	110 NX
Heart muscle	59 NX
Skin	36 NX

Spermatocytes	12 NX
Testis	12 NX

Spermatogonia	29 NX
Testis	29 NX

Suprabasal keratinocytes	64 NX
Skin	64 NX

Syncytiotrophoblasts	43 NX
Placenta	43 NX

T-cells	24 NX
Colon	42 NX
Lung	29 NX
Liver	24 NX
Kidney	24 NX
Skin	22 NX
Prostate	18 NX

Undifferentiated cells	24 NX
Colon	30 NX
Rectum	24 NX
Small intestine	20 NX

Urothelial cells	490 NX
Prostate	490 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.