Cell type atlas - DDRGK1 - The Human Protein Atlas

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DDRGK1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	DDRGK1
Gene descriptionⁱ Full gene name according to HGNC.	DDRGK domain containing 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	42 NX
Lung	42 NX

Alveolar cells type 2	49 NX
Lung	49 NX

B-cells	27 NX
Liver	40 NX
Kidney	31 NX
Colon	22 NX

Basal glandular cells	54 NX
Prostate	54 NX

Basal keratinocytes	23 NX
Skin	23 NX

Bipolar cells	43 NX
Eye	43 NX

Cardiomyocytes	28 NX
Heart muscle	28 NX

Cholangiocytes	104 NX
Liver	104 NX

Ciliated cells	44 NX
Lung	44 NX

Club cells	41 NX
Lung	41 NX

Collecting duct cells	66 NX
Kidney	66 NX

Cone photoreceptor cells	61 NX
Eye	61 NX

Cytotrophoblasts	111 NX
Placenta	111 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	129 NX
Pancreas	129 NX

Early spermatids	43 NX
Testis	43 NX

Endothelial cells	50 NX
Placenta	78 NX
Testis	77 NX
Eye	62 NX
Liver	54 NX
Skin	50 NX
Pancreas	50 NX
Prostate	45 NX
Heart muscle	34 NX
Lung	12 NX

Enterocytes	133 NX
Small intestine	167 NX
Colon	129 NX
Rectum	59 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	154 NX
Pancreas	154 NX

Extravillous trophoblasts	53 NX
Placenta	53 NX

Fibroblasts	43 NX
Placenta	85 NX
Prostate	56 NX
Skin	38 NX
Heart muscle	31 NX
Lung	25 NX

Glandular cells	64 NX
Prostate	64 NX

Granulocytes	28 NX
Colon	46 NX
Lung	9 NX

Hepatocytes	109 NX
Liver	109 NX

Hofbauer cells	107 NX
Placenta	107 NX

Horizontal cells	49 NX
Eye	49 NX

Intestinal endocrine cells	51 NX
Rectum	59 NX
Colon	44 NX

Ito cells	39 NX
Liver	39 NX

Kupffer cells	56 NX
Liver	56 NX

Late spermatids	13 NX
Testis	13 NX

Leydig cells	52 NX
Testis	52 NX

Macrophages	51 NX
Pancreas	117 NX
Prostate	60 NX
Kidney	58 NX
Testis	57 NX
Skin	38 NX
Lung	28 NX

Melanocytes	37 NX
Skin	37 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	61 NX
Pancreas	61 NX

Mucus-secreting cells	57 NX
Colon	76 NX
Small intestine	74 NX
Rectum	42 NX

Muller glia cells	61 NX
Eye	61 NX

Pancreatic endocrine cells	137 NX
Pancreas	137 NX

Paneth cells	123 NX
Colon	153 NX
Small intestine	123 NX
Rectum	63 NX

Peritubular cells	65 NX
Testis	65 NX

Proximal tubular cells	62 NX
Kidney	62 NX

Rod photoreceptor cells	92 NX
Eye	92 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	41 NX
Pancreas	71 NX
Prostate	52 NX
Skin	35 NX
Heart muscle	18 NX

Spermatocytes	36 NX
Testis	36 NX

Spermatogonia	21 NX
Testis	21 NX

Suprabasal keratinocytes	34 NX
Skin	34 NX

Syncytiotrophoblasts	122 NX
Placenta	122 NX

T-cells	31 NX
Colon	54 NX
Kidney	53 NX
Skin	38 NX
Liver	29 NX
Prostate	22 NX
Lung	20 NX

Undifferentiated cells	78 NX
Colon	95 NX
Small intestine	84 NX
Rectum	63 NX

Urothelial cells	57 NX
Prostate	57 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.