Cell type atlas - CD2AP - The Human Protein Atlas

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CD2AP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CD2AP
Gene descriptionⁱ Full gene name according to HGNC.	CD2 associated protein
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (plasmacytoid DC)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	53 NX
Lung	53 NX

B-cells	27 NX
Colon	33 NX
Kidney	27 NX
Liver	24 NX

Basal glandular cells	48 NX
Prostate	48 NX

Basal keratinocytes	29 NX
Skin	29 NX

Bipolar cells	10 NX
Eye	10 NX

Cardiomyocytes	14 NX
Heart muscle	14 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	75 NX
Lung	75 NX

Club cells	93 NX
Lung	93 NX

Collecting duct cells	68 NX
Kidney	68 NX

Cone photoreceptor cells	16 NX
Eye	16 NX

Cytotrophoblasts	42 NX
Placenta	42 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	68 NX
Pancreas	68 NX

Early spermatids	8 NX
Testis	8 NX

Endothelial cells	43 NX
Heart muscle	96 NX
Testis	69 NX
Lung	50 NX
Prostate	43 NX
Pancreas	43 NX
Liver	36 NX
Eye	36 NX
Skin	33 NX
Placenta	22 NX

Enterocytes	159 NX
Colon	197 NX
Rectum	174 NX
Small intestine	154 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	85 NX
Pancreas	85 NX

Extravillous trophoblasts	13 NX
Placenta	13 NX

Fibroblasts	11 NX
Lung	41 NX
Prostate	18 NX
Heart muscle	18 NX
Skin	11 NX
Placenta	9 NX

Glandular cells	76 NX
Prostate	76 NX

Granulocytes	23 NX
Lung	28 NX
Colon	18 NX

Hepatocytes	22 NX
Liver	22 NX

Hofbauer cells	16 NX
Placenta	16 NX

Horizontal cells	14 NX
Eye	14 NX

Intestinal endocrine cells	54 NX
Rectum	56 NX
Colon	51 NX

Ito cells	31 NX
Liver	31 NX

Kupffer cells	21 NX
Liver	21 NX

Late spermatids	8 NX
Testis	8 NX

Leydig cells	16 NX
Testis	16 NX

Macrophages	18 NX
Testis	28 NX
Prostate	26 NX
Pancreas	23 NX
Lung	18 NX
Kidney	10 NX
Skin	8 NX

Melanocytes	14 NX
Skin	14 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	12 NX
Pancreas	12 NX

Mucus-secreting cells	80 NX
Small intestine	115 NX
Colon	83 NX
Rectum	77 NX

Muller glia cells	12 NX
Eye	12 NX

Pancreatic endocrine cells	114 NX
Pancreas	114 NX

Paneth cells	82 NX
Colon	164 NX
Rectum	82 NX
Small intestine	60 NX

Peritubular cells	10 NX
Testis	10 NX

Proximal tubular cells	49 NX
Kidney	49 NX

Rod photoreceptor cells	13 NX
Eye	13 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	19 NX
Heart muscle	54 NX
Prostate	19 NX
Skin	18 NX
Pancreas	18 NX

Spermatocytes	22 NX
Testis	22 NX

Spermatogonia	31 NX
Testis	31 NX

Suprabasal keratinocytes	36 NX
Skin	36 NX

Syncytiotrophoblasts	34 NX
Placenta	34 NX

T-cells	20 NX
Lung	42 NX
Colon	30 NX
Skin	20 NX
Kidney	16 NX
Liver	15 NX
Prostate	0 NX

Undifferentiated cells	52 NX
Rectum	64 NX
Colon	62 NX
Small intestine	46 NX

Urothelial cells	104 NX
Prostate	104 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.