Expression of S100A6 in colorectal cancer

RECTUM ADENOCARCINOMA (READ) - Interactive survival scatter plotⁱ

The Survival Scatter plot shows the clinical status (i.e. dead or alive) for all individuals in the patient cohort, based on the same data that underlies the corresponding Kaplan-Meier plots. Patients that are alive at last time for follow-up are shown in blue and patients who have died during the study are shown in red.

The x-axis shows the expression levels (FPKM) of the investigated gene in the tumor tissue at the time of diagnosis. The y-axis shows the follow-up time after diagnosis (years). Both axes are complimented with kernel density curves demonstrating the data density over the axes. The top density plot shows the expression levels (FPKM) distribution among dead (red) and alive patients (blue). The right density plot shows the data density of the survived years of dead patients with high and low expression levels respectively, stratified using the cutoff indicated by the vertical dashed line through the Survival Scatter plot. This cutoff is automatically defined based on the FPKM cutoff that minimizes the p-score. The cutoff can be changed by dragging the vertical line or by entering a cutoff value in the square labeled "Current cut-off".

Under the Survival Scatter plot the p-score landscape (black curve; left axis) is shown together with dead median separation (red curve; right axis). Dead median separation is the difference in median mRNA expression between patients who have died with high and low expression, respectively. It is calculated as follows: median FPKM expression of dead patients with high expression - median FPKM expression of dead patients with low expression. This is intended to aid the user in visually exploring custom cutoffs and the associated p-scores and dead median separation.

Individual patient data is displayed and can be filtered by clicking on one or more of the category buttons on the top of the page. Categories describing expression level and patient information include: high, low, alive, dead, female, male and tumor stages. The scale of the x-axis can be toggled between linear and log-scale by clicking on the "x log" button. Mouse-over function shows TCGA ID, patient information and mRNA expression (FPKM) for each patient.

& Survival analysisⁱ

Stage:

Survival analysis

Current cut offⁱ:
Best expression cut offⁱ: 2043.35
Median expressionⁱ: N/A
Median follow up timeⁱ: N/A
P scoreⁱ N/A
5-year survival highⁱ N/A
5-year survival lowⁱ N/A

TCGA RNA samplesⁱ

Average FPKM

1569.0

Number of samples

159

Samples

Sample	Description	FPKM
TCGA-AG-3591-01A	66 years, female, stage:iia, alive, 1035 days	5616.1
TCGA-AG-3881-01A	83 years, female, stage:iia, alive, 579 days	5004.7
TCGA-DC-6155-01A	31 years, female, white, stage:iiia, alive, 425 days	4059.2
TCGA-DT-5265-01A	51 years, male, asian, stage:ii, alive, 384 days	3649.6
TCGA-F5-6464-01A	77 years, female, white, stage:iiic, dead, 303 days	3520.2
TCGA-DY-A1H8-01A	77 years, female, white, stage:iiia, dead, 992 days	3358.3
TCGA-AG-3599-01A	70 years, male, stage:i, alive, 366 days	3133.3
TCGA-AG-3609-01A	65 years, female, stage:iiic, alive, 608 days	3103.8
TCGA-EI-6507-01A	60 years, male, white, stage:iia, alive, 607 days	3049.3
TCGA-AG-3611-01A	72 years, male, stage:iia, alive, 424 days	3001.3
TCGA-AH-6544-01A	60 years, male, white, alive, 1173 days	2996.4
TCGA-AG-3892-01A	57 years, female, stage:i, alive, 396 days	2882.6
TCGA-DY-A1DF-01A	73 years, female, white, stage:iiic, dead, 734 days	2834.1
TCGA-AF-6672-01A	43 years, male, white, stage:iv, alive, 748 days	2695.8
TCGA-DY-A1DG-01A	75 years, male, white, stage:iva, dead, 1566 days	2675.6
TCGA-F5-6811-01A	72 years, female, white, stage:iia, alive, 979 days	2589.2
TCGA-DC-5337-01A	69 years, male, white, stage:i, alive, 792 days	2581.3
TCGA-F5-6861-01A	60 years, female, white, stage:iia, alive, 1160 days	2525.5
TCGA-AG-A032-01A	68 years, male, stage:iiib, alive, 1157 days	2468.4
TCGA-AG-3575-01A	51 years, male, stage:ii, alive, 365 days	2446.0
TCGA-EI-6881-01A	60 years, male, white, stage:iiia, alive, 499 days	2426.3
TCGA-AG-3600-01A	62 years, male, stage:iiic, alive, 184 days	2369.4
TCGA-AF-2693-01A	75 years, male, white, stage:i, alive, 1155 days	2336.0
TCGA-AG-3999-01A	61 years, female, stage:iiic, alive, 853 days	2328.1
TCGA-AF-6136-01A	72 years, female, white, stage:iiib, alive, 741 days	2316.8
TCGA-AG-3883-01A	69 years, male, stage:i, alive, 31 days	2313.0
TCGA-DC-4749-01A	57 years, male, white, stage:i, alive, 762 days	2311.2
TCGA-DC-6681-01A	70 years, female, white, stage:iva, alive, 790 days	2222.6
TCGA-G5-6641-01A	67 years, male, white, stage:iiia, alive, 804 days	2180.4
TCGA-AH-6643-01A	50 years, male, white, stage:iiic, dead, 1314 days	2175.1
TCGA-G5-6233-01A	74 years, male, white, dead, 556 days	2137.6
TCGA-DY-A1DC-01A	72 years, female, white, stage:iia, dead, 1258 days	2060.8
TCGA-BM-6198-01A	73 years, male, white, stage:iiib, alive, 646 days	2025.9
TCGA-DC-6154-01A	57 years, female, white, stage:iva, alive, 365 days	2017.7
TCGA-DY-A1DE-01A	56 years, female, white, stage:iia, alive, 3932 days	2004.9
TCGA-F5-6813-01A	70 years, male, white, stage:iiic, dead, 598 days	1989.1
TCGA-AG-3894-01A	65 years, male, stage:iia, alive, 426 days	1965.9
TCGA-AG-3902-01A	61 years, male, stage:iia, alive, 974 days	1948.8
TCGA-AF-4110-01A	77 years, male, white, stage:iva, alive, 912 days	1911.1
TCGA-EI-6884-01A	71 years, male, white, stage:iiia, alive, 328 days	1892.2
TCGA-CI-6622-01A	74 years, male, white, stage:iib, alive, 1362 days	1878.4
TCGA-AG-3598-01A	69 years, male, stage:iia, alive, 1522 days	1871.2
TCGA-AG-A00H-01A	75 years, male, stage:iia, alive, 790 days	1867.5
TCGA-CI-6624-01C	53 years, female, white, stage:i, alive, 1466 days	1852.7
TCGA-AG-A026-01A	66 years, male, stage:ii, dead, 59 days	1845.1
TCGA-AF-3911-01A	48 years, male, white, stage:iiic, alive, 1148 days	1817.4
TCGA-AH-6897-01A	48 years, male, white, stage:i, alive, 804 days	1780.3
TCGA-F5-6863-01A	71 years, female, white, stage:iiib, dead, 361 days	1732.3
TCGA-AF-A56N-01A	47 years, female, black or african american, stage:iia, alive, 360 days	1698.8
TCGA-F5-6812-01A	67 years, male, white, stage:iia, alive, 1110 days	1690.9
TCGA-DC-6683-01A	43 years, male, white, stage:iiib, alive, 762 days	1671.7
TCGA-CL-5918-01A	90 years, female, white, stage:iia, alive, 218 days	1658.8
TCGA-AG-3898-01A	61 years, male, stage:iia, alive, 1461 days	1644.0
TCGA-AG-3725-01A	90 years, female, stage:iii, alive, 638 days	1601.6
TCGA-AG-3594-01A	77 years, male, stage:iia, dead, 61 days	1595.8
TCGA-EI-7002-01A	58 years, male, white, stage:iv, alive, 364 days	1569.4
TCGA-EI-6514-01A	59 years, female, white, stage:iia, alive, 496 days	1567.9
TCGA-AG-3612-01A	55 years, female, stage:iiib, alive, 608 days	1564.1
TCGA-EF-5831-01A	72 years, male, white, stage:iia, alive, 127 days	1561.4
TCGA-CI-6623-01B	44 years, male, white, stage:i, alive, 1443 days	1550.5
TCGA-AG-A025-01A	62 years, female, stage:i, alive, 1520 days	1540.3
TCGA-EI-6506-01A	78 years, female, white, stage:iia, alive, 625 days	1533.6
TCGA-AG-3878-01A	64 years, male, stage:i, alive, 30 days	1497.5
TCGA-G5-6235-01A	72 years, male, white, stage:iiib, alive, 1696 days	1497.5
TCGA-AG-A01J-01A	59 years, female, stage:iia, alive, 31 days	1487.6
TCGA-AG-3608-01A	79 years, female, stage:iia, alive, 485 days	1478.3
TCGA-AG-A02N-01A	67 years, male, stage:ii, alive, 1885 days	1473.0
TCGA-EF-5830-01A	54 years, male, white, stage:iib, alive, 106 days	1449.3
TCGA-AG-A01N-01A	68 years, female, stage:iv, alive, 943 days	1445.5
TCGA-AG-A02X-01A	77 years, male, stage:i, alive, 1247 days	1422.2
TCGA-AG-4021-01A	84 years, female, stage:iv, dead, 121 days	1413.4
TCGA-AG-3909-01A	69 years, female, stage:iiib, alive, 608 days	1409.0
TCGA-AG-3578-01A	76 years, female, stage:iia, alive, 974 days	1408.6
TCGA-AG-4005-01A	64 years, male, stage:iv, alive, 427 days	1404.6
TCGA-CI-6621-01A	63 years, male, white, stage:iiib, alive, 419 days	1400.2
TCGA-AG-3896-01A	85 years, female, stage:i, alive, 31 days	1397.3
TCGA-AG-3885-01A	71 years, female, stage:iiib, alive, 546 days	1385.8
TCGA-AF-A56L-01A	48 years, female, black or african american, stage:iiic, alive, 2007 days	1381.8
TCGA-CI-6619-01B	41 years, male, white, stage:iv, alive, 184 days	1359.0
TCGA-AG-4007-01A	87 years, male, stage:iv, alive, 31 days	1353.1
TCGA-DC-6682-01A	57 years, male, white, stage:iia, alive, 762 days	1345.8
TCGA-EI-6882-01A	59 years, male, white, stage:iia, alive, 262 days	1343.1
TCGA-AG-4022-01A	59 years, female, stage:ii, alive, 1400 days	1332.8
TCGA-AG-A00C-01A	49 years, female, stage:iiib, alive, 183 days	1330.6
TCGA-EI-7004-01A	37 years, female, white, alive, 257 days	1321.0
TCGA-AF-3913-01A	60 years, male, black or african american, stage:iv, dead, 316 days	1314.0
TCGA-AG-3882-01A	66 years, female, stage:i, alive, 608 days	1305.4
TCGA-F5-6864-01A	74 years, female, white, stage:iiib, alive, 379 days	1288.4
TCGA-AF-5654-01A	73 years, female, white, stage:i, dead, 512 days	1282.2
TCGA-DC-5869-01A	62 years, female, black or african american, stage:iiib, alive, 943 days	1276.8
TCGA-EI-6512-01A	64 years, female, white, stage:iiib, alive, 538 days	1269.3
TCGA-DC-6160-01A	68 years, male, white, stage:i, alive, 1339 days	1269.3
TCGA-EI-6510-01A	77 years, female, white, alive, 556 days	1265.8
TCGA-AG-3581-01A	63 years, male, stage:i, alive, 215 days	1260.8
TCGA-AG-3901-01A	67 years, female, stage:iiib, alive, 761 days	1257.7
TCGA-DC-4745-01A	49 years, female, white, stage:iiib, alive, 639 days	1249.4
TCGA-AG-3583-01A	66 years, male, stage:iv, dead, 610 days	1249.0
TCGA-AH-6547-01A	79 years, female, white, dead, 76 days	1243.1
TCGA-AG-3580-01A	67 years, male, stage:i, alive, 244 days	1241.6
TCGA-G5-6572-01A	56 years, male, white, dead, 1432 days	1228.9
TCGA-AG-3586-01A	72 years, female, stage:iii, alive, 31 days	1216.4
TCGA-AG-3728-01A	73 years, male, stage:iiib, alive, 912 days	1215.4
TCGA-AG-A008-01A	50 years, female, stage:i, alive, 424 days	1208.5
TCGA-AH-6549-01A	66 years, male, white, alive, 532 days	1203.3
TCGA-AF-3400-01A	54 years, male, white, stage:iia, alive, 1049 days	1193.6
TCGA-AH-6644-01A	73 years, male, white, alive, 838 days	1187.2
TCGA-AG-3587-01A	65 years, male, stage:i, alive, 1400 days	1182.8
TCGA-AG-3592-01A	68 years, male, stage:iia, alive, 1035 days	1152.6
TCGA-AG-3742-01A	85 years, female, stage:i, alive, 30 days	1149.2
TCGA-AG-3584-01A	60 years, male, stage:iv, dead, 730 days	1128.9
TCGA-AF-6655-01A	66 years, male, white, stage:iiia, alive, 609 days	1125.6
TCGA-AG-A015-01A	64 years, female, stage:i, alive, 1096 days	1125.6
TCGA-F5-6702-01A	71 years, male, white, stage:iva, alive, 869 days	1117.5
TCGA-AG-3727-01A	78 years, female, stage:iii, alive, 30 days	1115.9
TCGA-EI-6508-01A	48 years, female, white, stage:iiib, alive, 636 days	1082.1
TCGA-AG-3893-01A	74 years, male, stage:iiib, alive, 1065 days	1079.1
TCGA-AF-2692-01A	54 years, female, white, stage:iia, alive, 412 days	1056.4
TCGA-AG-4008-01A	63 years, male, stage:iia, alive, 518 days	1054.0
TCGA-CI-6620-01A	41 years, female, white, stage:iva, alive, 1009 days	1049.2
TCGA-EI-6885-01A	57 years, female, white, stage:iv, alive, 415 days	1034.6
TCGA-AF-A56K-01A	56 years, male, black or african american, stage:iia, alive, 2635 days	1033.4
TCGA-AF-2691-01A	48 years, female, white, stage:i, alive, 1309 days	1023.4
TCGA-DC-6158-01A	70 years, male, white, stage:i, dead, 334 days	1002.7
TCGA-AG-A00Y-01A	68 years, male, stage:iia, alive, 700 days	996.6
TCGA-EI-6511-01A	52 years, male, white, stage:iiib, alive, 482 days	989.4
TCGA-AF-2687-01A	57 years, male, white, stage:iiic, alive, 1427 days	963.6
TCGA-AG-A020-01A	57 years, female, stage:iii, alive, 31 days	960.6
TCGA-AF-2690-01A	77 years, female, white, stage:iiic, dead, 524 days	960.2
TCGA-AG-3887-01A	68 years, male, stage:iia, alive, 1124 days	949.8
TCGA-AH-6903-01A	46 years, male, white, stage:iiib, alive, 592 days	944.3
TCGA-AG-3726-01A	63 years, female, stage:i, alive, 243 days	944.2
TCGA-CL-5917-01A	71 years, female, white, stage:iiic, alive, 2376 days	942.6
TCGA-AG-3605-01A	85 years, female, stage:iv, alive, 30 days	924.9
TCGA-AG-3582-01A	75 years, male, stage:iv, dead, 1096 days	912.8
TCGA-EI-6883-01A	63 years, male, white, stage:iic, alive, 350 days	880.9
TCGA-EI-6509-01A	53 years, male, white, stage:iiic, alive, 517 days	878.6
TCGA-CL-4957-01A	79 years, female, dead, 425 days	855.0
TCGA-DC-6156-01A	62 years, male, white, stage:iva, alive, 943 days	851.9
TCGA-AG-A014-01A	86 years, male, stage:i, alive, 485 days	850.7
TCGA-AG-3731-01A	65 years, male, stage:iv, alive, 1126 days	838.7
TCGA-DY-A0XA-01A	57 years, female, white, stage:iia, alive, 3846 days	829.9
TCGA-F5-6571-01A	62 years, female, white, stage:iia, alive, 1288 days	821.3
TCGA-AG-A011-01A	80 years, male, stage:iia, alive, 1126 days	791.0
TCGA-AG-A023-01A	62 years, female, stage:iv, dead, 1581 days	787.7
TCGA-AG-4001-01A	74 years, female, stage:iia, alive, 1096 days	777.8
TCGA-AG-3890-01A	62 years, male, stage:i, alive, 518 days	762.7
TCGA-EI-6917-01A	33 years, male, white, stage:iiia, alive, 531 days	760.9
TCGA-F5-6465-01A	64 years, female, white, stage:iia, alive, 1506 days	735.7
TCGA-AG-3593-01A	72 years, female, stage:iia, alive, 1035 days	727.6
TCGA-AG-A036-01A	71 years, male, stage:iii, alive, 3562 days	710.3
TCGA-AG-3574-01A	89 years, female, stage:ii, dead, 1096 days	673.9
TCGA-DY-A1DD-01A	77 years, female, white, stage:iiib, dead, 1741 days	671.8
TCGA-EI-6513-01A	59 years, male, white, stage:iiib, alive, 497 days	602.0
TCGA-F5-6814-01A	57 years, male, white, stage:iia, alive, 1131 days	589.9
TCGA-AG-A016-01A	55 years, male, stage:iv, alive, 276 days	563.6
TCGA-AG-A02G-01A	66 years, male, stage:iv, dead, 1185 days	537.4
TCGA-AG-A002-01A	35 years, male, stage:i, alive, 638 days	516.4
TCGA-DC-6157-01A	48 years, male, black or african american, stage:i, alive, 1581 days	341.5
TCGA-AG-3732-01A	78 years, female, stage:i, alive, 1003 days	339.4
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