Cell type atlas - GPAA1 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GPAA1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GPAA1
Gene descriptionⁱ Full gene name according to HGNC.	Glycosylphosphatidylinositol anchor attachment 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	5

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (PC-3)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	40 NX
Lung	40 NX

B-cells	43 NX
Liver	63 NX
Kidney	45 NX
Colon	42 NX

Basal glandular cells	40 NX
Prostate	40 NX

Basal keratinocytes	26 NX
Skin	26 NX

Bipolar cells	57 NX
Eye	57 NX

Cardiomyocytes	39 NX
Heart muscle	39 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	11 NX
Lung	11 NX

Collecting duct cells	42 NX
Kidney	42 NX

Cone photoreceptor cells	61 NX
Eye	61 NX

Cytotrophoblasts	107 NX
Placenta	107 NX

Distal tubular cells	22 NX
Kidney	22 NX

Ductal cells	111 NX
Pancreas	111 NX

Early spermatids	5 NX
Testis	5 NX

Endothelial cells	29 NX
Pancreas	54 NX
Placenta	52 NX
Liver	34 NX
Skin	31 NX
Eye	30 NX
Testis	29 NX
Lung	26 NX
Prostate	22 NX
Heart muscle	15 NX

Enterocytes	100 NX
Small intestine	130 NX
Colon	97 NX
Rectum	84 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	79 NX
Pancreas	79 NX

Extravillous trophoblasts	117 NX
Placenta	117 NX

Fibroblasts	53 NX
Placenta	74 NX
Skin	48 NX
Prostate	38 NX
Lung	22 NX
Heart muscle	20 NX

Glandular cells	53 NX
Prostate	53 NX

Granulocytes	66 NX
Colon	110 NX
Lung	21 NX

Hepatocytes	67 NX
Liver	67 NX

Hofbauer cells	79 NX
Placenta	79 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	55 NX
Colon	58 NX
Rectum	52 NX

Ito cells	43 NX
Liver	43 NX

Kupffer cells	46 NX
Liver	46 NX

Late spermatids	7 NX
Testis	7 NX

Leydig cells	37 NX
Testis	37 NX

Macrophages	40 NX
Pancreas	91 NX
Prostate	55 NX
Kidney	41 NX
Testis	39 NX
Skin	28 NX
Lung	27 NX

Melanocytes	69 NX
Skin	69 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	60 NX
Pancreas	60 NX

Mucus-secreting cells	47 NX
Small intestine	52 NX
Colon	46 NX
Rectum	38 NX

Muller glia cells	94 NX
Eye	94 NX

Pancreatic endocrine cells	70 NX
Pancreas	70 NX

Paneth cells	81 NX
Colon	89 NX
Small intestine	81 NX
Rectum	77 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	72 NX
Kidney	72 NX

Rod photoreceptor cells	54 NX
Eye	53 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	37 NX
Pancreas	112 NX
Prostate	44 NX
Skin	34 NX
Heart muscle	18 NX

Spermatocytes	133 NX
Testis	133 NX

Spermatogonia	52 NX
Testis	52 NX

Suprabasal keratinocytes	19 NX
Skin	19 NX

Syncytiotrophoblasts	91 NX
Placenta	91 NX

T-cells	48 NX
Liver	57 NX
Kidney	52 NX
Lung	45 NX
Colon	39 NX
Skin	34 NX
Prostate	22 NX

Undifferentiated cells	74 NX
Colon	80 NX
Small intestine	74 NX
Rectum	69 NX

Urothelial cells	37 NX
Prostate	37 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.