Cell type atlas - PSAP - The Human Protein Atlas

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PSAP

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PSAP
Gene descriptionⁱ Full gene name according to HGNC.	Prosaposin
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins Potential drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Hofbauer cells, Kupffer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (intermediate monocyte, non-classical monocyte, classical monocyte, myeloid DC, neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC diff, hTERT-RPE1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Hofbauer cells, Kupffer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	235 NX
Lung	235 NX

Alveolar cells type 2	379 NX
Lung	379 NX

B-cells	167 NX
Liver	225 NX
Colon	179 NX
Kidney	98 NX

Basal glandular cells	220 NX
Prostate	220 NX

Basal keratinocytes	203 NX
Skin	203 NX

Bipolar cells	180 NX
Eye	180 NX

Cardiomyocytes	543 NX
Heart muscle	543 NX

Cholangiocytes	255 NX
Liver	255 NX

Ciliated cells	220 NX
Lung	220 NX

Club cells	234 NX
Lung	234 NX

Collecting duct cells	452 NX
Kidney	452 NX

Cone photoreceptor cells	120 NX
Eye	120 NX

Cytotrophoblasts	794 NX
Placenta	794 NX

Distal tubular cells	60 NX
Kidney	60 NX

Ductal cells	787 NX
Pancreas	787 NX

Early spermatids	16 NX
Testis	16 NX

Endothelial cells	344 NX
Liver	384 NX
Placenta	382 NX
Eye	367 NX
Pancreas	362 NX
Lung	344 NX
Heart muscle	336 NX
Skin	297 NX
Testis	237 NX
Prostate	202 NX

Enterocytes	354 NX
Rectum	427 NX
Colon	389 NX
Small intestine	348 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	403 NX
Pancreas	403 NX

Extravillous trophoblasts	742 NX
Placenta	742 NX

Fibroblasts	529 NX
Skin	664 NX
Heart muscle	629 NX
Prostate	559 NX
Lung	322 NX
Placenta	310 NX

Glandular cells	294 NX
Prostate	294 NX

Granulocytes	383 NX
Lung	463 NX
Colon	303 NX

Hepatocytes	395 NX
Liver	395 NX

Hofbauer cells	2783 NX
Placenta	2783 NX

Horizontal cells	315 NX
Eye	315 NX

Intestinal endocrine cells	252 NX
Rectum	300 NX
Colon	204 NX

Ito cells	411 NX
Liver	411 NX

Kupffer cells	2078 NX
Liver	2078 NX

Late spermatids	31 NX
Testis	31 NX

Leydig cells	425 NX
Testis	425 NX

Macrophages	1465 NX
Pancreas	3657 NX
Kidney	2633 NX
Lung	1894 NX
Prostate	1491 NX
Testis	946 NX
Skin	788 NX

Melanocytes	629 NX
Skin	629 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1298 NX
Pancreas	1298 NX

Mucus-secreting cells	227 NX
Rectum	275 NX
Colon	234 NX
Small intestine	151 NX

Muller glia cells	506 NX
Eye	506 NX

Pancreatic endocrine cells	336 NX
Pancreas	336 NX

Paneth cells	285 NX
Rectum	287 NX
Colon	285 NX
Small intestine	235 NX

Peritubular cells	519 NX
Testis	519 NX

Proximal tubular cells	243 NX
Kidney	243 NX

Rod photoreceptor cells	122 NX
Eye	122 NX

Sertoli cells	272 NX
Testis	272 NX

Smooth muscle cells	278 NX
Pancreas	401 NX
Heart muscle	338 NX
Prostate	275 NX
Skin	255 NX

Spermatocytes	43 NX
Testis	43 NX

Spermatogonia	120 NX
Testis	120 NX

Suprabasal keratinocytes	173 NX
Skin	173 NX

Syncytiotrophoblasts	897 NX
Placenta	897 NX

T-cells	140 NX
Lung	349 NX
Skin	182 NX
Kidney	176 NX
Prostate	140 NX
Liver	127 NX
Colon	91 NX

Undifferentiated cells	184 NX
Rectum	228 NX
Colon	219 NX
Small intestine	123 NX

Urothelial cells	185 NX
Prostate	185 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.