Cell type atlas - RPF2 - The Human Protein Atlas

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RPF2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RPF2
Gene descriptionⁱ Full gene name according to HGNC.	Ribosome production factor 2 homolog
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	27 NX
Lung	27 NX

B-cells	21 NX
Colon	28 NX
Liver	26 NX
Kidney	9 NX

Basal glandular cells	95 NX
Prostate	95 NX

Basal keratinocytes	70 NX
Skin	70 NX

Bipolar cells	13 NX
Eye	13 NX

Cardiomyocytes	61 NX
Heart muscle	61 NX

Cholangiocytes	46 NX
Liver	46 NX

Ciliated cells	62 NX
Lung	62 NX

Club cells	64 NX
Lung	64 NX

Collecting duct cells	17 NX
Kidney	17 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	41 NX
Placenta	41 NX

Distal tubular cells	58 NX
Kidney	58 NX

Ductal cells	41 NX
Pancreas	41 NX

Early spermatids	73 NX
Testis	72 NX

Endothelial cells	33 NX
Prostate	57 NX
Pancreas	50 NX
Heart muscle	39 NX
Lung	38 NX
Liver	36 NX
Placenta	32 NX
Skin	31 NX
Testis	21 NX
Eye	20 NX

Enterocytes	12 NX
Small intestine	13 NX
Rectum	10 NX
Colon	7 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	41 NX
Pancreas	41 NX

Extravillous trophoblasts	44 NX
Placenta	44 NX

Fibroblasts	41 NX
Lung	105 NX
Heart muscle	66 NX
Prostate	63 NX
Placenta	40 NX
Skin	28 NX

Glandular cells	42 NX
Prostate	42 NX

Granulocytes	44 NX
Lung	60 NX
Colon	28 NX

Hepatocytes	67 NX
Liver	67 NX

Hofbauer cells	48 NX
Placenta	48 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	11 NX
Rectum	12 NX
Colon	10 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	27 NX
Liver	27 NX

Late spermatids	20 NX
Testis	20 NX

Leydig cells	32 NX
Testis	32 NX

Macrophages	27 NX
Lung	40 NX
Kidney	33 NX
Prostate	29 NX
Testis	23 NX
Pancreas	23 NX
Skin	21 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	18 NX
Pancreas	18 NX

Mucus-secreting cells	27 NX
Colon	34 NX
Rectum	31 NX
Small intestine	18 NX

Muller glia cells	19 NX
Eye	19 NX

Pancreatic endocrine cells	37 NX
Pancreas	37 NX

Paneth cells	21 NX
Rectum	27 NX
Small intestine	21 NX
Colon	3 NX

Peritubular cells	26 NX
Testis	26 NX

Proximal tubular cells	70 NX
Kidney	70 NX

Rod photoreceptor cells	8 NX
Eye	8 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	35 NX
Prostate	64 NX
Pancreas	63 NX
Heart muscle	35 NX
Skin	35 NX

Spermatocytes	37 NX
Testis	37 NX

Spermatogonia	27 NX
Testis	27 NX

Suprabasal keratinocytes	58 NX
Skin	58 NX

Syncytiotrophoblasts	29 NX
Placenta	29 NX

T-cells	18 NX
Prostate	48 NX
Lung	32 NX
Kidney	32 NX
Colon	20 NX
Skin	18 NX
Liver	8 NX

Undifferentiated cells	33 NX
Colon	64 NX
Small intestine	33 NX
Rectum	29 NX

Urothelial cells	65 NX
Prostate	65 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.