Cell type atlas - TRIM33 - The Human Protein Atlas

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TRIM33

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TRIM33
Gene descriptionⁱ Full gene name according to HGNC.	Tripartite motif containing 33
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (MCF7)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	30 NX
Lung	29 NX

B-cells	19 NX
Colon	43 NX
Liver	19 NX
Kidney	13 NX

Basal glandular cells	26 NX
Prostate	26 NX

Basal keratinocytes	47 NX
Skin	47 NX

Bipolar cells	72 NX
Eye	72 NX

Cardiomyocytes	22 NX
Heart muscle	22 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	11 NX
Lung	11 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	52 NX
Kidney	52 NX

Cone photoreceptor cells	92 NX
Eye	92 NX

Cytotrophoblasts	50 NX
Placenta	50 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	18 NX
Pancreas	18 NX

Early spermatids	155 NX
Testis	155 NX

Endothelial cells	31 NX
Testis	46 NX
Skin	39 NX
Eye	38 NX
Heart muscle	37 NX
Placenta	29 NX
Prostate	29 NX
Liver	29 NX
Lung	12 NX
Pancreas	11 NX

Enterocytes	24 NX
Rectum	37 NX
Colon	24 NX
Small intestine	23 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	21 NX
Pancreas	20 NX

Extravillous trophoblasts	28 NX
Placenta	28 NX

Fibroblasts	32 NX
Skin	34 NX
Prostate	33 NX
Heart muscle	26 NX
Placenta	25 NX
Lung	15 NX

Glandular cells	38 NX
Prostate	38 NX

Granulocytes	37 NX
Colon	46 NX
Lung	28 NX

Hepatocytes	41 NX
Liver	41 NX

Hofbauer cells	26 NX
Placenta	26 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	50 NX
Colon	51 NX
Rectum	49 NX

Ito cells	37 NX
Liver	37 NX

Kupffer cells	45 NX
Liver	45 NX

Late spermatids	79 NX
Testis	79 NX

Leydig cells	46 NX
Testis	46 NX

Macrophages	39 NX
Prostate	44 NX
Skin	42 NX
Lung	38 NX
Testis	37 NX
Kidney	30 NX
Pancreas	9 NX

Melanocytes	19 NX
Skin	19 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	17 NX
Pancreas	17 NX

Mucus-secreting cells	31 NX
Rectum	34 NX
Small intestine	31 NX
Colon	18 NX

Muller glia cells	34 NX
Eye	34 NX

Pancreatic endocrine cells	25 NX
Pancreas	25 NX

Paneth cells	33 NX
Colon	40 NX
Rectum	33 NX
Small intestine	21 NX

Peritubular cells	35 NX
Testis	35 NX

Proximal tubular cells	13 NX
Kidney	13 NX

Rod photoreceptor cells	58 NX
Eye	58 NX

Sertoli cells	32 NX
Testis	32 NX

Smooth muscle cells	24 NX
Skin	42 NX
Prostate	39 NX
Heart muscle	23 NX
Pancreas	11 NX

Spermatocytes	54 NX
Testis	54 NX

Spermatogonia	30 NX
Testis	30 NX

Suprabasal keratinocytes	48 NX
Skin	48 NX

Syncytiotrophoblasts	73 NX
Placenta	73 NX

T-cells	36 NX
Skin	53 NX
Colon	50 NX
Liver	45 NX
Kidney	32 NX
Lung	29 NX
Prostate	18 NX

Undifferentiated cells	29 NX
Rectum	33 NX
Small intestine	28 NX
Colon	16 NX

Urothelial cells	49 NX
Prostate	49 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.