Cell type atlas - METTL9 - The Human Protein Atlas

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METTL9

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	METTL9
Gene descriptionⁱ Full gene name according to HGNC.	Methyltransferase like 9
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Proximal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Proximal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	18 NX
Lung	18 NX

Alveolar cells type 2	25 NX
Lung	25 NX

B-cells	68 NX
Kidney	71 NX
Colon	64 NX
Liver	59 NX

Basal glandular cells	73 NX
Prostate	73 NX

Basal keratinocytes	64 NX
Skin	64 NX

Bipolar cells	39 NX
Eye	39 NX

Cardiomyocytes	51 NX
Heart muscle	51 NX

Cholangiocytes	28 NX
Liver	28 NX

Ciliated cells	17 NX
Lung	17 NX

Club cells	25 NX
Lung	25 NX

Collecting duct cells	82 NX
Kidney	82 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	63 NX
Placenta	63 NX

Distal tubular cells	239 NX
Kidney	239 NX

Ductal cells	102 NX
Pancreas	102 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	91 NX
Prostate	129 NX
Testis	119 NX
Placenta	105 NX
Pancreas	100 NX
Skin	100 NX
Liver	61 NX
Eye	56 NX
Heart muscle	44 NX
Lung	29 NX

Enterocytes	45 NX
Small intestine	64 NX
Rectum	61 NX
Colon	31 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	107 NX
Pancreas	107 NX

Extravillous trophoblasts	99 NX
Placenta	99 NX

Fibroblasts	83 NX
Prostate	104 NX
Placenta	85 NX
Skin	80 NX
Lung	35 NX
Heart muscle	34 NX

Glandular cells	115 NX
Prostate	115 NX

Granulocytes	48 NX
Colon	83 NX
Lung	14 NX

Hepatocytes	10 NX
Liver	10 NX

Hofbauer cells	81 NX
Placenta	81 NX

Horizontal cells	43 NX
Eye	43 NX

Intestinal endocrine cells	82 NX
Colon	95 NX
Rectum	68 NX

Ito cells	80 NX
Liver	80 NX

Kupffer cells	212 NX
Liver	211 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	59 NX
Testis	59 NX

Macrophages	87 NX
Pancreas	164 NX
Kidney	131 NX
Testis	129 NX
Skin	87 NX
Prostate	78 NX
Lung	47 NX

Melanocytes	100 NX
Skin	100 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	102 NX
Pancreas	102 NX

Mucus-secreting cells	77 NX
Rectum	77 NX
Colon	69 NX
Small intestine	60 NX

Muller glia cells	50 NX
Eye	50 NX

Pancreatic endocrine cells	99 NX
Pancreas	99 NX

Paneth cells	46 NX
Rectum	72 NX
Small intestine	46 NX
Colon	23 NX

Peritubular cells	61 NX
Testis	61 NX

Proximal tubular cells	327 NX
Kidney	327 NX

Rod photoreceptor cells	38 NX
Eye	37 NX

Sertoli cells	65 NX
Testis	65 NX

Smooth muscle cells	68 NX
Pancreas	115 NX
Prostate	86 NX
Skin	66 NX
Heart muscle	29 NX

Spermatocytes	13 NX
Testis	13 NX

Spermatogonia	20 NX
Testis	20 NX

Suprabasal keratinocytes	67 NX
Skin	67 NX

Syncytiotrophoblasts	116 NX
Placenta	116 NX

T-cells	146 NX
Skin	212 NX
Liver	167 NX
Colon	147 NX
Kidney	112 NX
Prostate	87 NX
Lung	25 NX

Undifferentiated cells	75 NX
Small intestine	95 NX
Rectum	75 NX
Colon	54 NX

Urothelial cells	107 NX
Prostate	107 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.