Cell type atlas - CASP4 - The Human Protein Atlas

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CASP4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CASP4
Gene descriptionⁱ Full gene name according to HGNC.	Caspase 4
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	57 NX
Lung	57 NX

Alveolar cells type 2	58 NX
Lung	57 NX

B-cells	87 NX
Colon	131 NX
Kidney	94 NX
Liver	61 NX

Basal glandular cells	54 NX
Prostate	54 NX

Basal keratinocytes	50 NX
Skin	50 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	4 NX
Heart muscle	4 NX

Cholangiocytes	41 NX
Liver	41 NX

Ciliated cells	72 NX
Lung	72 NX

Club cells	55 NX
Lung	55 NX

Collecting duct cells	21 NX
Kidney	21 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	114 NX
Placenta	114 NX

Distal tubular cells	13 NX
Kidney	13 NX

Ductal cells	119 NX
Pancreas	119 NX

Early spermatids	1 NX
Testis	0 NX

Endothelial cells	69 NX
Lung	143 NX
Prostate	98 NX
Testis	92 NX
Heart muscle	78 NX
Skin	77 NX
Liver	67 NX
Placenta	43 NX
Eye	43 NX
Pancreas	39 NX

Enterocytes	12 NX
Small intestine	65 NX
Rectum	10 NX
Colon	7 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	164 NX
Pancreas	164 NX

Extravillous trophoblasts	66 NX
Placenta	66 NX

Fibroblasts	46 NX
Lung	106 NX
Skin	46 NX
Prostate	43 NX
Placenta	42 NX
Heart muscle	28 NX

Glandular cells	29 NX
Prostate	29 NX

Granulocytes	34 NX
Lung	40 NX
Colon	28 NX

Hepatocytes	27 NX
Liver	27 NX

Hofbauer cells	102 NX
Placenta	102 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	20 NX
Colon	24 NX
Rectum	16 NX

Ito cells	65 NX
Liver	65 NX

Kupffer cells	149 NX
Liver	148 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	27 NX
Testis	27 NX

Macrophages	96 NX
Lung	185 NX
Kidney	166 NX
Testis	142 NX
Pancreas	98 NX
Prostate	93 NX
Skin	76 NX

Melanocytes	29 NX
Skin	29 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	63 NX
Pancreas	63 NX

Mucus-secreting cells	28 NX
Small intestine	67 NX
Rectum	25 NX
Colon	13 NX

Muller glia cells	2 NX
Eye	2 NX

Pancreatic endocrine cells	153 NX
Pancreas	153 NX

Paneth cells	10 NX
Small intestine	14 NX
Rectum	10 NX
Colon	0 NX

Peritubular cells	19 NX
Testis	19 NX

Proximal tubular cells	31 NX
Kidney	31 NX

Rod photoreceptor cells	0 NX
Eye	0 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	23 NX
Pancreas	79 NX
Prostate	31 NX
Heart muscle	18 NX
Skin	18 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	40 NX
Skin	40 NX

Syncytiotrophoblasts	97 NX
Placenta	97 NX

T-cells	118 NX
Liver	167 NX
Kidney	163 NX
Colon	118 NX
Lung	102 NX
Skin	82 NX
Prostate	44 NX

Undifferentiated cells	18 NX
Small intestine	58 NX
Rectum	18 NX
Colon	13 NX

Urothelial cells	68 NX
Prostate	68 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.