Cell type atlas - AMZ2 - The Human Protein Atlas

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AMZ2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	AMZ2
Gene descriptionⁱ Full gene name according to HGNC.	Archaelysin family metallopeptidase 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Group enriched (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	12 NX
Lung	12 NX

Alveolar cells type 2	14 NX
Lung	14 NX

B-cells	28 NX
Colon	30 NX
Kidney	27 NX
Liver	24 NX

Basal glandular cells	32 NX
Prostate	32 NX

Basal keratinocytes	17 NX
Skin	17 NX

Bipolar cells	13 NX
Eye	13 NX

Cardiomyocytes	73 NX
Heart muscle	73 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	58 NX
Lung	58 NX

Club cells	22 NX
Lung	22 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	8 NX
Eye	8 NX

Cytotrophoblasts	54 NX
Placenta	54 NX

Distal tubular cells	93 NX
Kidney	93 NX

Ductal cells	25 NX
Pancreas	25 NX

Early spermatids	585 NX
Testis	585 NX

Endothelial cells	25 NX
Liver	38 NX
Heart muscle	34 NX
Testis	31 NX
Skin	26 NX
Pancreas	25 NX
Placenta	24 NX
Eye	24 NX
Lung	23 NX
Prostate	10 NX

Enterocytes	9 NX
Small intestine	12 NX
Rectum	12 NX
Colon	6 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	23 NX
Pancreas	23 NX

Extravillous trophoblasts	57 NX
Placenta	57 NX

Fibroblasts	32 NX
Heart muscle	46 NX
Placenta	32 NX
Skin	30 NX
Prostate	24 NX
Lung	22 NX

Glandular cells	18 NX
Prostate	18 NX

Granulocytes	32 NX
Lung	47 NX
Colon	18 NX

Hepatocytes	14 NX
Liver	14 NX

Hofbauer cells	37 NX
Placenta	37 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	20 NX
Rectum	31 NX
Colon	10 NX

Ito cells	23 NX
Liver	23 NX

Kupffer cells	20 NX
Liver	20 NX

Late spermatids	1308 NX
Testis	1308 NX

Leydig cells	33 NX
Testis	33 NX

Macrophages	37 NX
Skin	64 NX
Prostate	53 NX
Testis	41 NX
Pancreas	33 NX
Lung	29 NX
Kidney	28 NX

Melanocytes	54 NX
Skin	54 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	57 NX
Pancreas	57 NX

Mucus-secreting cells	17 NX
Small intestine	19 NX
Rectum	17 NX
Colon	9 NX

Muller glia cells	56 NX
Eye	56 NX

Pancreatic endocrine cells	24 NX
Pancreas	24 NX

Paneth cells	13 NX
Small intestine	14 NX
Rectum	13 NX
Colon	3 NX

Peritubular cells	31 NX
Testis	31 NX

Proximal tubular cells	49 NX
Kidney	49 NX

Rod photoreceptor cells	12 NX
Eye	12 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	27 NX
Pancreas	36 NX
Heart muscle	27 NX
Skin	27 NX
Prostate	16 NX

Spermatocytes	187 NX
Testis	187 NX

Spermatogonia	54 NX
Testis	54 NX

Suprabasal keratinocytes	20 NX
Skin	20 NX

Syncytiotrophoblasts	29 NX
Placenta	29 NX

T-cells	51 NX
Skin	65 NX
Prostate	57 NX
Liver	57 NX
Kidney	47 NX
Lung	43 NX
Colon	39 NX

Undifferentiated cells	16 NX
Small intestine	17 NX
Rectum	15 NX
Colon	6 NX

Urothelial cells	16 NX
Prostate	16 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.