Cell type atlas - NACA - The Human Protein Atlas

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NACA

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NACA
Gene descriptionⁱ Full gene name according to HGNC.	Nascent polypeptide-associated complex alpha subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	13

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	414 NX
Lung	414 NX

Alveolar cells type 2	564 NX
Lung	564 NX

B-cells	1474 NX
Kidney	1586 NX
Liver	1474 NX
Colon	929 NX

Basal glandular cells	1870 NX
Prostate	1870 NX

Basal keratinocytes	1801 NX
Skin	1801 NX

Bipolar cells	295 NX
Eye	295 NX

Cardiomyocytes	578 NX
Heart muscle	578 NX

Cholangiocytes	938 NX
Liver	938 NX

Ciliated cells	440 NX
Lung	440 NX

Club cells	720 NX
Lung	720 NX

Collecting duct cells	375 NX
Kidney	375 NX

Cone photoreceptor cells	63 NX
Eye	63 NX

Cytotrophoblasts	1562 NX
Placenta	1562 NX

Distal tubular cells	1507 NX
Kidney	1507 NX

Ductal cells	1063 NX
Pancreas	1063 NX

Early spermatids	561 NX
Testis	561 NX

Endothelial cells	1210 NX
Prostate	1895 NX
Testis	1809 NX
Skin	1375 NX
Liver	1252 NX
Placenta	1210 NX
Pancreas	935 NX
Eye	767 NX
Lung	510 NX
Heart muscle	337 NX

Enterocytes	674 NX
Small intestine	1201 NX
Rectum	625 NX
Colon	523 NX

Erythroid cells	420 NX
Liver	420 NX

Exocrine glandular cells	1761 NX
Pancreas	1761 NX

Extravillous trophoblasts	2400 NX
Placenta	2400 NX

Fibroblasts	1080 NX
Prostate	1339 NX
Placenta	1150 NX
Skin	1001 NX
Lung	842 NX
Heart muscle	397 NX

Glandular cells	1342 NX
Prostate	1342 NX

Granulocytes	713 NX
Lung	765 NX
Colon	661 NX

Hepatocytes	646 NX
Liver	646 NX

Hofbauer cells	1391 NX
Placenta	1391 NX

Horizontal cells	173 NX
Eye	173 NX

Intestinal endocrine cells	622 NX
Rectum	698 NX
Colon	547 NX

Ito cells	710 NX
Liver	710 NX

Kupffer cells	1197 NX
Liver	1197 NX

Late spermatids	485 NX
Testis	485 NX

Leydig cells	2231 NX
Testis	2231 NX

Macrophages	1465 NX
Testis	1961 NX
Kidney	1801 NX
Prostate	1534 NX
Skin	1465 NX
Pancreas	931 NX
Lung	794 NX

Melanocytes	1176 NX
Skin	1176 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	1425 NX
Pancreas	1425 NX

Mucus-secreting cells	1175 NX
Rectum	1972 NX
Colon	1124 NX
Small intestine	917 NX

Muller glia cells	459 NX
Eye	459 NX

Pancreatic endocrine cells	1466 NX
Pancreas	1466 NX

Paneth cells	1052 NX
Rectum	1833 NX
Small intestine	1052 NX
Colon	671 NX

Peritubular cells	1345 NX
Testis	1345 NX

Proximal tubular cells	1858 NX
Kidney	1858 NX

Rod photoreceptor cells	338 NX
Eye	338 NX

Sertoli cells	789 NX
Testis	789 NX

Smooth muscle cells	1298 NX
Prostate	1560 NX
Skin	1377 NX
Pancreas	1088 NX
Heart muscle	490 NX

Spermatocytes	499 NX
Testis	499 NX

Spermatogonia	490 NX
Testis	490 NX

Suprabasal keratinocytes	1951 NX
Skin	1951 NX

Syncytiotrophoblasts	1943 NX
Placenta	1943 NX

T-cells	1209 NX
Skin	1500 NX
Kidney	1455 NX
Prostate	1260 NX
Liver	1040 NX
Colon	739 NX
Lung	644 NX

Undifferentiated cells	1657 NX
Small intestine	1702 NX
Rectum	1687 NX
Colon	967 NX

Urothelial cells	2038 NX
Prostate	2038 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.