Cell type atlas - SULT1A1 - The Human Protein Atlas

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SULT1A1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SULT1A1
Gene descriptionⁱ Full gene name according to HGNC.	Sulfotransferase family 1A member 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Enterocytes, Paneth cells, Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (classical monocyte, neutrophil, intermediate monocyte, myeloid DC, non-classical monocyte)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Group enriched (EFO-21, Hep G2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Enterocytes, Paneth cells, Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	179 NX
Lung	179 NX

Alveolar cells type 2	78 NX
Lung	78 NX

B-cells	8 NX
Kidney	9 NX
Colon	7 NX
Liver	5 NX

Basal glandular cells	7 NX
Prostate	7 NX

Basal keratinocytes	1 NX
Skin	1 NX

Bipolar cells	17 NX
Eye	17 NX

Cardiomyocytes	12 NX
Heart muscle	12 NX

Cholangiocytes	43 NX
Liver	43 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	16 NX
Kidney	16 NX

Cone photoreceptor cells	10 NX
Eye	10 NX

Cytotrophoblasts	2 NX
Placenta	2 NX

Distal tubular cells	110 NX
Kidney	110 NX

Ductal cells	10 NX
Pancreas	10 NX

Early spermatids	94 NX
Testis	94 NX

Endothelial cells	8 NX
Liver	90 NX
Heart muscle	30 NX
Lung	18 NX
Eye	10 NX
Placenta	8 NX
Prostate	4 NX
Testis	3 NX
Skin	1 NX
Pancreas	0 NX

Enterocytes	530 NX
Small intestine	777 NX
Colon	297 NX
Rectum	211 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	18 NX
Pancreas	18 NX

Extravillous trophoblasts	1 NX
Placenta	1 NX

Fibroblasts	16 NX
Lung	49 NX
Placenta	31 NX
Heart muscle	31 NX
Prostate	6 NX
Skin	5 NX

Glandular cells	3 NX
Prostate	3 NX

Granulocytes	48 NX
Lung	67 NX
Colon	28 NX

Hepatocytes	207 NX
Liver	207 NX

Hofbauer cells	32 NX
Placenta	32 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	19 NX
Rectum	28 NX
Colon	10 NX

Ito cells	43 NX
Liver	43 NX

Kupffer cells	193 NX
Liver	193 NX

Late spermatids	26 NX
Testis	26 NX

Leydig cells	48 NX
Testis	48 NX

Macrophages	39 NX
Kidney	113 NX
Pancreas	54 NX
Lung	48 NX
Testis	34 NX
Skin	12 NX
Prostate	11 NX

Melanocytes	2 NX
Skin	2 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	16 NX
Pancreas	16 NX

Mucus-secreting cells	40 NX
Small intestine	121 NX
Rectum	35 NX
Colon	32 NX

Muller glia cells	66 NX
Eye	66 NX

Pancreatic endocrine cells	6 NX
Pancreas	6 NX

Paneth cells	295 NX
Colon	446 NX
Small intestine	295 NX
Rectum	92 NX

Peritubular cells	33 NX
Testis	33 NX

Proximal tubular cells	17 NX
Kidney	17 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	10 NX
Pancreas	41 NX
Skin	13 NX
Heart muscle	9 NX
Prostate	7 NX

Spermatocytes	20 NX
Testis	20 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	0 NX
Skin	0 NX

Syncytiotrophoblasts	2 NX
Placenta	2 NX

T-cells	8 NX
Lung	19 NX
Kidney	10 NX
Prostate	9 NX
Liver	7 NX
Colon	7 NX
Skin	4 NX

Undifferentiated cells	70 NX
Small intestine	83 NX
Rectum	49 NX
Colon	46 NX

Urothelial cells	6 NX
Prostate	6 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.