Cell type atlas - PTPN1 - The Human Protein Atlas

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PTPN1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	PTPN1
Gene descriptionⁱ Full gene name according to HGNC.	Protein tyrosine phosphatase, non-receptor type 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes, Alveolar cells type 1)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes, Alveolar cells type 1)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	211 NX
Lung	211 NX

Alveolar cells type 2	72 NX
Lung	72 NX

B-cells	68 NX
Colon	140 NX
Liver	68 NX
Kidney	49 NX

Basal glandular cells	44 NX
Prostate	44 NX

Basal keratinocytes	76 NX
Skin	76 NX

Bipolar cells	23 NX
Eye	23 NX

Cardiomyocytes	27 NX
Heart muscle	27 NX

Cholangiocytes	10 NX
Liver	10 NX

Ciliated cells	32 NX
Lung	32 NX

Club cells	48 NX
Lung	48 NX

Collecting duct cells	35 NX
Kidney	35 NX

Cone photoreceptor cells	45 NX
Eye	45 NX

Cytotrophoblasts	42 NX
Placenta	42 NX

Distal tubular cells	20 NX
Kidney	20 NX

Ductal cells	21 NX
Pancreas	21 NX

Early spermatids	47 NX
Testis	47 NX

Endothelial cells	26 NX
Liver	74 NX
Prostate	68 NX
Lung	61 NX
Eye	38 NX
Skin	22 NX
Pancreas	22 NX
Heart muscle	22 NX
Placenta	17 NX
Testis	14 NX

Enterocytes	20 NX
Rectum	27 NX
Colon	24 NX
Small intestine	8 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	17 NX
Pancreas	17 NX

Extravillous trophoblasts	17 NX
Placenta	17 NX

Fibroblasts	21 NX
Prostate	198 NX
Lung	72 NX
Placenta	26 NX
Skin	19 NX
Heart muscle	16 NX

Glandular cells	27 NX
Prostate	27 NX

Granulocytes	67 NX
Lung	98 NX
Colon	37 NX

Hepatocytes	19 NX
Liver	19 NX

Hofbauer cells	33 NX
Placenta	33 NX

Horizontal cells	41 NX
Eye	41 NX

Intestinal endocrine cells	18 NX
Rectum	19 NX
Colon	17 NX

Ito cells	37 NX
Liver	37 NX

Kupffer cells	28 NX
Liver	28 NX

Late spermatids	22 NX
Testis	22 NX

Leydig cells	13 NX
Testis	13 NX

Macrophages	52 NX
Prostate	197 NX
Skin	95 NX
Lung	89 NX
Pancreas	56 NX
Kidney	43 NX
Testis	25 NX

Melanocytes	35 NX
Skin	35 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	327 NX
Pancreas	327 NX

Mucus-secreting cells	14 NX
Colon	18 NX
Rectum	15 NX
Small intestine	9 NX

Muller glia cells	14 NX
Eye	14 NX

Pancreatic endocrine cells	29 NX
Pancreas	29 NX

Paneth cells	12 NX
Rectum	17 NX
Colon	12 NX
Small intestine	11 NX

Peritubular cells	11 NX
Testis	11 NX

Proximal tubular cells	60 NX
Kidney	60 NX

Rod photoreceptor cells	26 NX
Eye	26 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	34 NX
Prostate	201 NX
Heart muscle	37 NX
Skin	30 NX
Pancreas	27 NX

Spermatocytes	21 NX
Testis	21 NX

Spermatogonia	24 NX
Testis	24 NX

Suprabasal keratinocytes	41 NX
Skin	41 NX

Syncytiotrophoblasts	45 NX
Placenta	45 NX

T-cells	44 NX
Prostate	109 NX
Lung	99 NX
Colon	72 NX
Skin	44 NX
Kidney	37 NX
Liver	34 NX

Undifferentiated cells	16 NX
Rectum	16 NX
Colon	16 NX
Small intestine	8 NX

Urothelial cells	55 NX
Prostate	55 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.