Cell type atlas - CD55 - The Human Protein Atlas

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CD55

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CD55
Gene descriptionⁱ Full gene name according to HGNC.	CD55 molecule (Cromer blood group)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Blood group antigen proteins CD markers Disease related genes Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Alveolar cells type 1)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (neutrophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HeLa, HMC-1, PC-3, U-2197)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Alveolar cells type 1)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	2070 NX
Lung	2070 NX

Alveolar cells type 2	359 NX
Lung	359 NX

B-cells	93 NX
Colon	453 NX
Kidney	103 NX
Liver	67 NX

Basal glandular cells	173 NX
Prostate	173 NX

Basal keratinocytes	626 NX
Skin	626 NX

Bipolar cells	1 NX
Eye	1 NX

Cardiomyocytes	63 NX
Heart muscle	63 NX

Cholangiocytes	3 NX
Liver	3 NX

Ciliated cells	390 NX
Lung	390 NX

Club cells	704 NX
Lung	704 NX

Collecting duct cells	23 NX
Kidney	23 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	192 NX
Placenta	192 NX

Distal tubular cells	3 NX
Kidney	3 NX

Ductal cells	55 NX
Pancreas	55 NX

Early spermatids	312 NX
Testis	312 NX

Endothelial cells	62 NX
Prostate	465 NX
Pancreas	272 NX
Skin	228 NX
Lung	131 NX
Eye	62 NX
Placenta	57 NX
Testis	54 NX
Heart muscle	54 NX
Liver	27 NX

Enterocytes	158 NX
Colon	269 NX
Small intestine	84 NX
Rectum	41 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	163 NX
Pancreas	163 NX

Extravillous trophoblasts	371 NX
Placenta	371 NX

Fibroblasts	199 NX
Prostate	442 NX
Skin	300 NX
Lung	218 NX
Heart muscle	68 NX
Placenta	40 NX

Glandular cells	136 NX
Prostate	136 NX

Granulocytes	142 NX
Lung	156 NX
Colon	129 NX

Hepatocytes	7 NX
Liver	7 NX

Hofbauer cells	62 NX
Placenta	62 NX

Horizontal cells	2 NX
Eye	2 NX

Intestinal endocrine cells	17 NX
Colon	24 NX
Rectum	9 NX

Ito cells	41 NX
Liver	41 NX

Kupffer cells	161 NX
Liver	161 NX

Late spermatids	60 NX
Testis	60 NX

Leydig cells	30 NX
Testis	30 NX

Macrophages	161 NX
Prostate	316 NX
Lung	303 NX
Skin	277 NX
Testis	164 NX
Kidney	148 NX
Pancreas	115 NX

Melanocytes	152 NX
Skin	152 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	53 NX
Pancreas	53 NX

Mucus-secreting cells	67 NX
Colon	287 NX
Small intestine	63 NX
Rectum	58 NX

Muller glia cells	6 NX
Eye	6 NX

Pancreatic endocrine cells	239 NX
Pancreas	239 NX

Paneth cells	151 NX
Colon	412 NX
Small intestine	151 NX
Rectum	83 NX

Peritubular cells	9 NX
Testis	9 NX

Proximal tubular cells	3 NX
Kidney	3 NX

Rod photoreceptor cells	3 NX
Eye	2 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	61 NX
Prostate	228 NX
Skin	99 NX
Pancreas	61 NX
Heart muscle	14 NX

Spermatocytes	8 NX
Testis	8 NX

Spermatogonia	4 NX
Testis	4 NX

Suprabasal keratinocytes	670 NX
Skin	670 NX

Syncytiotrophoblasts	709 NX
Placenta	709 NX

T-cells	76 NX
Prostate	314 NX
Skin	208 NX
Colon	151 NX
Lung	125 NX
Kidney	59 NX
Liver	46 NX

Undifferentiated cells	69 NX
Colon	243 NX
Small intestine	72 NX
Rectum	64 NX

Urothelial cells	492 NX
Prostate	492 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.