Cell type atlas - NDUFA4 - The Human Protein Atlas

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NDUFA4

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NDUFA4
Gene descriptionⁱ Full gene name according to HGNC.	NDUFA4, mitochondrial complex associated
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Cardiomyocytes, Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Cardiomyocytes, Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	456 NX
Lung	456 NX

Alveolar cells type 2	387 NX
Lung	387 NX

B-cells	389 NX
Liver	514 NX
Kidney	508 NX
Colon	270 NX

Basal glandular cells	473 NX
Prostate	473 NX

Basal keratinocytes	362 NX
Skin	362 NX

Bipolar cells	472 NX
Eye	472 NX

Cardiomyocytes	3966 NX
Heart muscle	3966 NX

Cholangiocytes	996 NX
Liver	996 NX

Ciliated cells	704 NX
Lung	704 NX

Club cells	534 NX
Lung	534 NX

Collecting duct cells	904 NX
Kidney	904 NX

Cone photoreceptor cells	251 NX
Eye	251 NX

Cytotrophoblasts	757 NX
Placenta	757 NX

Distal tubular cells	3356 NX
Kidney	3356 NX

Ductal cells	749 NX
Pancreas	749 NX

Early spermatids	116 NX
Testis	116 NX

Endothelial cells	550 NX
Heart muscle	676 NX
Liver	575 NX
Placenta	573 NX
Pancreas	566 NX
Skin	480 NX
Testis	449 NX
Prostate	322 NX
Lung	301 NX
Eye	238 NX

Enterocytes	533 NX
Colon	533 NX
Small intestine	531 NX
Rectum	467 NX

Erythroid cells	187 NX
Liver	187 NX

Exocrine glandular cells	833 NX
Pancreas	833 NX

Extravillous trophoblasts	599 NX
Placenta	599 NX

Fibroblasts	543 NX
Heart muscle	1321 NX
Placenta	689 NX
Lung	563 NX
Skin	453 NX
Prostate	335 NX

Glandular cells	717 NX
Prostate	717 NX

Granulocytes	552 NX
Lung	709 NX
Colon	395 NX

Hepatocytes	1498 NX
Liver	1498 NX

Hofbauer cells	845 NX
Placenta	845 NX

Horizontal cells	149 NX
Eye	149 NX

Intestinal endocrine cells	201 NX
Colon	211 NX
Rectum	192 NX

Ito cells	748 NX
Liver	748 NX

Kupffer cells	553 NX
Liver	553 NX

Late spermatids	82 NX
Testis	82 NX

Leydig cells	457 NX
Testis	457 NX

Macrophages	588 NX
Pancreas	920 NX
Kidney	879 NX
Prostate	595 NX
Skin	574 NX
Lung	499 NX
Testis	427 NX

Melanocytes	869 NX
Skin	869 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	626 NX
Pancreas	626 NX

Mucus-secreting cells	610 NX
Colon	916 NX
Rectum	646 NX
Small intestine	412 NX

Muller glia cells	384 NX
Eye	384 NX

Pancreatic endocrine cells	637 NX
Pancreas	637 NX

Paneth cells	584 NX
Rectum	594 NX
Colon	584 NX
Small intestine	519 NX

Peritubular cells	737 NX
Testis	737 NX

Proximal tubular cells	2070 NX
Kidney	2070 NX

Rod photoreceptor cells	472 NX
Eye	472 NX

Sertoli cells	330 NX
Testis	330 NX

Smooth muscle cells	933 NX
Heart muscle	1366 NX
Prostate	933 NX
Pancreas	904 NX
Skin	750 NX

Spermatocytes	106 NX
Testis	106 NX

Spermatogonia	275 NX
Testis	275 NX

Suprabasal keratinocytes	422 NX
Skin	422 NX

Syncytiotrophoblasts	551 NX
Placenta	551 NX

T-cells	350 NX
Kidney	662 NX
Skin	469 NX
Prostate	366 NX
Lung	365 NX
Liver	315 NX
Colon	297 NX

Undifferentiated cells	618 NX
Rectum	623 NX
Colon	618 NX
Small intestine	545 NX

Urothelial cells	678 NX
Prostate	678 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.