Cell type atlas - TUBB4B - The Human Protein Atlas

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TUBB4B

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	TUBB4B
Gene descriptionⁱ Full gene name according to HGNC.	Tubulin beta 4B class IVb
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Spermatocytes, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Spermatocytes, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	205 NX
Lung	205 NX

Alveolar cells type 2	140 NX
Lung	140 NX

B-cells	151 NX
Colon	248 NX
Liver	177 NX
Kidney	54 NX

Basal glandular cells	843 NX
Prostate	843 NX

Basal keratinocytes	290 NX
Skin	290 NX

Bipolar cells	457 NX
Eye	457 NX

Cardiomyocytes	82 NX
Heart muscle	82 NX

Cholangiocytes	133 NX
Liver	133 NX

Ciliated cells	1027 NX
Lung	1027 NX

Club cells	175 NX
Lung	175 NX

Collecting duct cells	136 NX
Kidney	136 NX

Cone photoreceptor cells	283 NX
Eye	283 NX

Cytotrophoblasts	236 NX
Placenta	236 NX

Distal tubular cells	187 NX
Kidney	187 NX

Ductal cells	349 NX
Pancreas	349 NX

Early spermatids	1755 NX
Testis	1755 NX

Endothelial cells	152 NX
Prostate	351 NX
Pancreas	279 NX
Eye	222 NX
Placenta	179 NX
Skin	154 NX
Liver	151 NX
Testis	119 NX
Lung	105 NX
Heart muscle	27 NX

Enterocytes	547 NX
Colon	728 NX
Rectum	454 NX
Small intestine	415 NX

Erythroid cells	491 NX
Liver	491 NX

Exocrine glandular cells	392 NX
Pancreas	391 NX

Extravillous trophoblasts	458 NX
Placenta	458 NX

Fibroblasts	162 NX
Prostate	401 NX
Placenta	170 NX
Skin	154 NX
Lung	134 NX
Heart muscle	42 NX

Glandular cells	365 NX
Prostate	365 NX

Granulocytes	189 NX
Colon	276 NX
Lung	102 NX

Hepatocytes	114 NX
Liver	114 NX

Hofbauer cells	229 NX
Placenta	229 NX

Horizontal cells	230 NX
Eye	230 NX

Intestinal endocrine cells	376 NX
Colon	415 NX
Rectum	337 NX

Ito cells	130 NX
Liver	130 NX

Kupffer cells	67 NX
Liver	67 NX

Late spermatids	2132 NX
Testis	2132 NX

Leydig cells	235 NX
Testis	235 NX

Macrophages	111 NX
Pancreas	264 NX
Prostate	205 NX
Skin	158 NX
Lung	94 NX
Testis	92 NX
Kidney	59 NX

Melanocytes	132 NX
Skin	132 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	360 NX
Pancreas	360 NX

Mucus-secreting cells	293 NX
Colon	737 NX
Small intestine	335 NX
Rectum	267 NX

Muller glia cells	271 NX
Eye	271 NX

Pancreatic endocrine cells	344 NX
Pancreas	344 NX

Paneth cells	375 NX
Colon	1278 NX
Small intestine	375 NX
Rectum	206 NX

Peritubular cells	144 NX
Testis	144 NX

Proximal tubular cells	260 NX
Kidney	260 NX

Rod photoreceptor cells	647 NX
Eye	647 NX

Sertoli cells	110 NX
Testis	110 NX

Smooth muscle cells	245 NX
Pancreas	506 NX
Prostate	321 NX
Skin	204 NX
Heart muscle	58 NX

Spermatocytes	1762 NX
Testis	1762 NX

Spermatogonia	565 NX
Testis	565 NX

Suprabasal keratinocytes	260 NX
Skin	260 NX

Syncytiotrophoblasts	269 NX
Placenta	269 NX

T-cells	98 NX
Prostate	353 NX
Colon	303 NX
Skin	179 NX
Lung	98 NX
Kidney	64 NX
Liver	56 NX

Undifferentiated cells	359 NX
Colon	545 NX
Small intestine	359 NX
Rectum	229 NX

Urothelial cells	575 NX
Prostate	575 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.